Osteoarthritis is the most common of the more than 200 forms of arthritis, affecting over 20 per cent of the population. Unfortunately, there are currently no effective treatments or approved drugs for this disabling condition, which causes the joints to become painful and stiff. Some new drugs are in the pipeline, but it will be years before they are tested in clinical trials and ...
Source: Dana-Farber Cancer Institute Feb 18, 2019 3 years ago
A combination of two drugs -- one of them an immunotherapy agent -- could become a new standard, first-line treatment for patients with metastatic kidney cancer, says an investigator from Dana-Farber Cancer Institute, reporting results from a phase 3 clinical trial.
Patients who received the immunotherapy drug avelumab plus axitinib, a targeted agent, had a significant advantage in progression-...
Overcoming Formulation Challenges of Biotherapeutics:
The increasing study of vaccines and biotherapeutics gives promise for improvement of treatments against various diseases. While protein engineering has shown a great level of growth, several of these therapies persist in the face of ex vivo uncertainty challenges (both physical and chemical instability) which are a source of dosage form inadeq...
Source: Thailand Medical News Feb 17, 2019 3 years ago
Multiple therapies involving ablative and nonablative techniques have been developed for rejuvenation of photodamaged skin. Monopolar radiofrequency (RF) is emerging as a gentler, nonablative skin-tightening device that delivers uniform heat to the dermis at a controlled depth.
In a recent study done by Dr Moetaz El-Domyati, Head of Dermatologists at Minia University, Egypt in collaborati...
Source: Thailand Medical News Feb 17, 2019 3 years ago
Updated treatment guidelines and the availability of the ResistancePlus GC test for Neisseria gonorrhoeae, from SpeeDx Inc, Sydney, Australia, are making it possible for some UK patients with gonorrhea to be treated with the cheap and easily-administered oral antibiotic ciprofloxacin.
Ciprofloxacin was the first-line antibiotic of choice for uncomplicated gonorrhea in the ...
Source: St Thomas' Biomedical Research Centre Feb 17, 2019 3 years ago
A new technique using patients' own modified cells to treat Crohn's disease has been proven to be effective in experiments using human cells, with a clinical trial of the treatment expected to start in the next six months.
Researchers at the NIHR Guy's and St Thomas' Biomedical Research Centre (BRC) developed the technique by studying white blood cells taken from patien...
Source: NRG Oncology, Pennsylvania Feb 17, 2019 3 years ago
The NRG Oncology clinical study NRG-RTOG 0415 determined that a hypofractionated radiotherapy schedule (H-RT), a treatment schedule that delivers a total dose of radiotherapy over a shorter period of time, is not worse than the conventional radiotherapy schedule (C-RT) in terms of bowel, bladder, sexual, and general quality of life (QOL) as well as anxiety and depression for men with low risk pros...
Twelve patients who tried injections of stem cells were hospitalized with infections, according to a report in the New York Times that should cause patients concern. More important is that they should investigate stem cell treatments, for conditions such as cartilage injuries to their joints, before committing to one of these procedures. It's also a valuable reminder that physic...
Source: Oregon Health and Science University Feb 16, 2019 3 years ago
A team of researchers from Oregon Health and Science University has concluded from an extensive study involving a medicinal plant called Centella Asiatica, commonly known as Gotu Kola (in thai: bua bok ) is effective in terms of improving memory especially in the elderly and those afflicted with cognitive related diseases.
Centella Asiatica contains a variety of phyto chemicals such ...
Source: University of Exeter Feb 16, 2019 3 years ago
Scientists have discovered new ways in which the body regulates blood clots, in a discovery which could one day lead to the development of better treatments that could help prevent and treat conditions including heart diseases, stroke and vascular dementia.
Led by the University of Exeter and funded by the British Heart Foundation, the team has developed a new technique that allows ...
Takeda Pharmaceutical Company Feb 15, 2019 3 years ago
– ADCETRIS in Combination with AVD (Adriamycin, Vinblastine and Dacarbazine) Demonstrated 29-Percent Reduction in the Risk of Progression, Death or Need for Additional Anticancer Therapy for CD30+ Stage IV Patients
– Milestone Marks Fifth Approved Indication for ADCETRIS in Europe, Reinforcing Takeda’s Commitment to Developing Innovative Solutions for People Li...
Source: George Mason University Feb 15, 2019 3 years ago
George Mason University's Yuntao Wu is the lead scientist on a research team that has identified a measurable indicator that could prove instrumental in the fight against HIV.
The research focuses on cofilin, a key protein that regulates cells to mobilize and fight against infection.
In an HIV-infected patient, cofilin dysfunction is a key factor in helper T cell defects, according to the r...
Source: ETH Zurich University Feb 15, 2019 3 years ago
In recent years, the number of targeted cancer drugs has continued to rise. However, conventional chemotherapeutic agents still play an important role in cancer treatment. These include platinum-based cytotoxic agents that attack and kill cancer cells. But these agents also damage healthy tissue and cause severe side effects. Researchers at ETH Zurich have now identified an approach that allows fo...
Source: University Hospital Basel Feb 15, 2019 3 years ago
There is a higher risk of fragility bone fracture for people with diabetes, and a new study was able to identify a key factor specific to type 1 diabetes (T1D) patients.
The study in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism reports that poor glucose control significantly reduces the risk, in T1D patients, of a fall from standing height or...
Source: University of Virginia Feb 15, 2019 3 years ago
An antidepressant drug used to treat obsessive-compulsive disorder could save people from deadly sepsis, new research from the University of Virginia School of Medicine suggests.
Sepsis is a significant cause of death around the world. The federal Centers for Disease Control and Infection calls it "the body's extreme response to an infection." Essentially, the body's immune re...
A variety of health care trackers, including the Apple Watch, offer consumers the ability to record their ECG signals. Though the claims about these offerings are mostly accurate, they may be misleading to those that believe these devices mimic the capabilities of in-hospital ECGs. In reality, wrist-worn and other wearable ECG monitors are only single-lead devices that can pretty much only detect ...
As in much of the rest of the developed and middle-income nations, diabetes is creating a public health crisis in Thailand. Doctors face a complicated set of challenges related to the illness – not only in how to treat those already affected, but how to prevent the debilitating disease moving into the future. Measures such as proper dietary education and the promotion of exercise, especially...
Source: University of Leicester Feb 14, 2019 3 years ago
Results from a phase II clinical trial, experimental work on cells and computational modelling have together shown why the first pill for asthma in 20 years can help reduce asthma attacks.
Researchers from Leicester (UK) and Vancouver (Canada) have shown that the investigational drug, Fevipiprant (an oral, selective prostaglandin D2 receptor antagonist), reduces the amount of smooth muscle in t...
Source: University of Cambridge/ University of Leicester Feb 13, 2019 3 years ago
A blood test has been developed that could save countless lives by improving early detection of lung cancer. The test measures circulating DNA that is shed by cancer cells as they grow and multiply. Scientists believe it could predict the presence of low-grade tumours in the lungs long before they become a threat.
New research led by scientists at the Medical Research Council (MRC) Toxico...
Source: Stanford University School of Medicine Feb 12, 2019 3 years ago
An antibody-based treatment can gently and effectively eliminate diseased blood-forming stem cells in the bone marrow to prepare for the transplantation of healthy stem cells, according to a study in mice by researchers at the Stanford University School of Medicine.
The researchers believe the treatment could circumvent the need to use harsh, potentially life-threatening chemotherapy or radiati...
Source: Beth Israel Deaconess Medical Center Feb 11, 2019 3 years ago
Lightheadedness with standing, otherwise known as postural lightheadedness, results from a gravitational drop in blood pressure and is common among adults. While mild in many adults, it has been cited as an important contributing factor in some harmful clinical events, such as falls. As a result, greater sodium intake is widely viewed as an intervention for preventing lightheadedness when moving f...
Source: The Institute of Cancer Research, London Feb 10, 2019 3 years ago
A brand new type of cancer drug that acts as a ‘Trojan horse’ to get inside tumour cells has shown promise in patients with six different cancer types.
In patients with advanced, drug-resistant cancers, over a quarter with cervical and bladder tumours, and nearly 15 per cent with ovarian and lung tumours, responded to the new treatment.
The innovative new drug, called tisotumab ved...
Source: Duke University Medical Center Feb 09, 2019 3 years ago
The use of MRI to determine heart function has been slow to catch on, but a study from Duke Health researchers shows that stress cardiac MRI not only diagnoses disease, but can also predict which cases are potentially fatal.
Results from a large, multi-center study suggest that cardiac magnetic resonance, or CMR, has potential as a non-invasive, non-toxic alternative to stress echocardiograms, ...
Source: Massachusetts Institute of Technology Feb 08, 2019 3 years ago
An MIT-led research team has developed a drug capsule that could be used to deliver oral doses of insulin, potentially replacing the injections that people with type 2 diabetes have to give themselves every day.
An MIT-led research team has developed a drug capsule that could
be used to deliver oral doses of insulin. Credit: Felice Frankel
About the size of a blueberry, the capsule contains a...
Source: Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem (INBEB), Brazil Feb 07, 2019 3 years ago
Scientists explored mRNA and protein public databases to unravel hidden meanings of the genetic code. Using a metric derived from mRNA codon composition, they found out how gene sequence choice can predict different aspects of protein synthesis, such as protein production efficiency. The study could help the development of new biotechnological applications of genes and proteins.
Today, thousand...
Thailand’s PrEP Implementation Progress With Exclusive Interview Comments From Professor Andrew Grulich – The Kirby Institute, UNSW, Sydney
PrEP implementation was a very hot, challenging topic at the 21st Bangkok International Symposium on HIV Medicine 2019 organised by HIV-NAT.
The Symposium was held at The Queen Sirikit National Convention Centre, January 16-18th..
The latter par...
Executives of Chiang Mai Ram Hospital recently paid a visit to the Myanmar Consulate in Chiang Mai to discuss cooperation between Myanmar and the Hospital’s initiative to a be a centre for Myanmar Patients seeking premium healthcare services.
The delegation led by Dr. Pramuk Unachak and Dr. Sira Hantrakul, Directors of the hospital along with its Customer Services Team met up with the Con...
Source: University Of Waterloo Feb 07, 2019 3 years ago
Researchers at the University of Waterloo have developed a new way to prevent and treat Chlamydia, the most common sexually transmitted bacterial infection in the world.
Chlamydia in a human cell.
The new treatment differs from the traditional anti-biotic treatment as it is a type of gene therapy that is delivered via nanotechnology and is showing a 65 per cent success rate in preventing c...
Source: Thailand Medical News Feb 06, 2019 3 years ago
Fat is complicated. It's stubborn, demonized, praised, misunderstood. As the recent wave of body positive conversations has helped to scratch at, everyone's relationship with fat is different. One thing that has remained fairly consistent is a cultural obsession with mastering fat — whether that means embracing it, or erasing it.
As far as the latter is concerned, plastic surgery ha...
Source : American Physiological Society. Feb 06, 2019 3 years ago
Lower-than-normal zinc levels may contribute to high blood pressure (hypertension) by altering the way the kidneys handle sodium. The study is published in the American Journal of Physiology -- Renal Physiology.
Zinc deficiency is common in people with chronic illnesses such as type 2 diabetes and chronic kidney disease. People with low zinc levels are also at a higher risk for hyper...
Source: Stanford University School of Medicine Feb 06, 2019 3 years ago
In rheumatoid arthritis, immune cells called helper T cells behave differently from their counterparts in healthy cells and in other autoimmune diseases. Stanford scientists have learned why.
Stanford University School of Medicine investigators succeeded in countering inflammation and tissue damage caused by rheumatoid arthritis in mice engrafted with human joint-lining tissue and...
Source: Cancer Research UK Feb 06, 2019 3 years ago
Mutations that cause esophageal adenocarcinoma (OAC) have been mapped in unprecedented detail -- unveiling that more than half could be targeted by drugs currently in trials for other cancer types.
This research, published in Nature Genetics, could help stratify esophageal cancer patients to give them more personalised therapies. This could provide options not currently available to ...
Tris Pharma Inc. voluntarily recalled three lots of Infants’ Ibuprofen Concentrated Oral Suspension, USP 50 mg per 1.25 mL, to the retail level. The recalled lots of the product have been found to have potentially higher concentrations of ibuprofen than normal.
Images of packagings of recalled products
“There is a remote possibility that infants, who may be more susceptible to...
Source: Friedrich-Alexander Universitat(FAU),Germany Feb 05, 2019 3 years ago
More than 4000,000 people in Germany are affected by the chronic inflammatory bowel diseases Morbus Crohn or ulcerative colitis. Patients often suffer from flare-ups, which damage intestinal tissue. In spite of tremendous advances in treating the diseases with medication, the chronic inflammation still cannot be kept sufficiently in check for a number of patients. Until now, little has been known ...
Contributed By Benjamin Bartee Feb 05, 2019 3 years ago
Thailand, Bangkok in particular, has emerged in recent decades as the worldwide leader in medical tourism, while simultaneously achieving interrelated healthcare milestones, with enormous tangential benefits to its own economy and population as well as to the world at large. Estimates by the U.S. National Library of Medicine indicate that, in 2013, the Kingdom attracted between 700,000 and 2.5 mil...
Source: McGill University Feb 05, 2019 3 years ago
Two new papers, published simultaneously in Nature Communications and led by researchers at McGill University, offer promise that a drug currently used to treat estrogen positive breast cancer may be effective in treating two different types of cancer, one rare and one common form.
The breakthrough discovery launching this research came in 2014 when Dr. William Foulkes, ...
Source: VIB (the Flanders Institute for Biotechnology) Feb 04, 2019 3 years ago
Identical twin toddlers who presented with severe arthritis helped scientists to identify the first gene mutation that can single-handedly cause a juvenile form of this inflammatory joint disease. By investigating the DNA of individual blood cells of both children and then modelling the genetic defect in a mouse model, the research team led by Adrian Liston (VIB-KU Leuven) was able to unravel the ...
Source: University of Texas Health Science Center at San Antonio Feb 04, 2019 3 years ago
In long-term survivors of childhood cancer, cardiovascular disease is a leading cause of early death from non-cancer causes. In a new study, published in JAMA Oncology, researchers compared four chemotherapy drugs with development of cardiomyopathy (abnormal heart muscle with impaired function) years after treatment.
"Exposure to anthracycline chemotherapies, such ...
Source: Louisiana State University Health Sciences Center Feb 03, 2019 3 years ago
Dr. Paul Harch, Clinical Professor and Director of Hyperbaric Medicine at LSU Health New Orleans School of Medicine, and Dr. Edward Fogarty, Chairman of Radiology at the University of North Dakota School of Medicine, report the first PET scan-documented case of improvement in brain metabolism in Alzheimer's disease in a patient treated with hyperbaric oxygen therapy (HBOT).
The authors...
Source: Thailand Medical News Feb 03, 2019 3 years ago
Hetero, one of India’s leading generic pharmaceutical companies and world’s largest producer of anti-retroviral drugs, announces the launch of generic version of lapatinib (250 mg) tablets in India. The product is marketed and distributed under the brand name ‘Hertab’ by Hetero Healthcare Ltd. It is made available in two SKUs, each consisting of 30 tablets and 150 tablets.
...
Source: Thailand Medical News Feb 03, 2019 3 years ago
Medipines, a company based in California’s Orange County, obtained US FDA clearance for its MediPines Gas Exchange Monitor. The device is used to measure and monitor a variety of respiratory parameters and indices of patients presenting with lung conditions.
It can help to quickly triage patients and make decision making easier by providing parameters such as&nbs...
Source: Thailand Medical News Feb 03, 2019 3 years ago
Kanika's blood pressure was "through the roof." She had gained a lot weight. A history of heart disease ran deep in her immediate family.
When she looks back at herself in 2016, the year she suffered a stroke, she sees a "stubborn old buffalo" in denial about her health.
"I had let my blood pressure go uncontrolled and I remained overweight for so long," sa...
Source: Thailand Medical News Feb 03, 2019 3 years ago
Fenugreek is an herb in the same family as soy. People use its fresh and dried seeds, leaves, twigs, and roots as a spice, flavoring agent, and supplement. While more research is necessary, some studies show that fenugreek may have varied health benefits.
Fenugreek may be able to help reduce the risk of:
-cancer
-diabetes
-obesity
-high cholesterol
-high blo...
Source: Charité - Universitätsmedizin Berlin Feb 03, 2019 3 years ago
Researchers at Universitätsmedizin Berlin have discovered a protective mechanism which is used by the body to protect intestinal stem cells from turning cancerous. The body's innate immune system was found to play a pivotal role in this regard. The researchers were able to demonstrate that, rather than having a purely defensive role, the immune system is crucial in maintaining a healthy b...
Source: Simon Fraser University Feb 03, 2019 3 years ago
The immune system is the body's best defense in fighting diseases like HIV and cancer. Now, an international team of researchers is harnessing the immune system to reveal new clues that may help in efforts to produce an HIV vaccine.
SFU professor Mark Brockman and co-authors from the University of KwaZulu-Natal in South Africa have identified a connection between infection cont...
Source: Universitat Polytechnica de Valencia (UPV),Spain Feb 03, 2019 3 years ago
Autoimmune diseases, such as systemic lupus erythematosus or rheumatoid arthritis, are difficult to diagnose, specially in early stages. Specifically, in the case of lupus, specific antibodies aimed at antigens located in the nucleus of cells appear, including the anti-Ro/SSA. These anti-Ro/SSA antibodies can be found in the blood before other autoantibodies related with lupus, and can even be det...
Source: Duke University Medical Center Feb 02, 2019 3 years ago
A Duke Health pilot project suggests that in the near future, a blood test could show whether arteries carrying blood to the heart are narrow or blocked, a risk factor for heart disease.
According to the 40-person study published in the journal PLOS ONE, emergency patients who underwent a treadmill stress test and showed signs of decreased blood flow to the heart also had changes in five met...
Source: University of San Diego Feb 01, 2019 3 years ago
Search for a description of "p53" and it becomes clear that this human protein is widely known for its cancer-fighting benefits, leading to its renown as "the guardian of the genome."
Scientists at the University of California San Diego have published a new study challenging that description.
Studying the "wild type" version of p53 (WTp53), the form that exists b...
Source: Howard Hughes Medical Institute Jan 31, 2019 3 years ago
Researchers can now quickly and accurately count a hidden, inactive form of the human immunodeficiency virus (HIV) that lurks in patients' cells. This version of HIV embeds into cells' genomes and can persist despite otherwise successful therapies, thwarting attempts to cure the infection.
Using a new genetic technique developed by Howard Hughes Medical Institute Investigator Robert Sil...
Source: Brigham and Women's Hospital Jan 30, 2019 3 years ago
In the United States, the drug price for insulin has skyrocketed over the last two decades. While the price has increased for all forms of insulin, newer, "analogue" insulin medications such as glargine and lispro have become especially expensive.
This is particularly true for patients with insufficient drug coverage or for Medicare beneficiaries in the Part D coverage gap. CareMore ...
An often-overlooked type of STD, oral gonorrhea presents a challenge for healthcare in Thailand and globally. The threat this bacterial infection poses is not limited to the disease itself – there are large-scale public health issues related both to long-term inflammation by an infection in the throat or mouth left untreated and to the wrongful prescription of certain antibiotics that give r...
Source: Purdue University Jan 29, 2019 3 years ago
Researchers have been struggling for years to find a treatment for patients who have a recurrence of acute myeloid leukemia (AML), an aggressive blood cancer that is one of the most lethal cancers. About 19,520 news cases are diagnosed a year, and about 10,670 people a year die from it, according to the American Cancer Society.
Purdue University researchers are developing a series of drug compo...
Source: University of California - San Diego Jan 28, 2019 3 years ago
A team of researchers led by the University of California San Diego has identified a genetic pathway that causes some individuals to develop an abnormal heart rhythm, or arrhythmia, after experiencing a heart attack. They have also identified a drug candidate that can block this pathway.
"We now know one reason why a significant fraction of the public could develop secondary complications p...
Source: Thailand Medical News Jan 28, 2019 3 years ago
In recent years, various agencies within the Thai government have made concerted efforts to curb private medical institutions’ independence by installing burdensome regulations -- most recently by seeking to control what these businesses can charge for specific medicines, procedures, and supplies. Their basic rationale is that cost controls and other measures are necessary to ensure the best...
Source: University of California, San Francisco Jan 28, 2019 3 years ago
Regular use of a common type of medication, such as aspirin and ibuprofen, significantly improves survival for a third or more patients with head and neck cancer, a new study led by UC San Francisco has found.
Non-steroidal anti-inflammatory drugs, or NSAIDs, improved the overall five-year survival rate from 25 percent to 78 percent for patients whose cancer contained a specific...
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