BREAKING! Study Shockingly Finds That A Form Of Vitamin B3 Supplements Actually Increases Cancer Prevalence And Aids In Breast Cancer Metastases!
A new study by researchers from Department of Chemistry, University of Missouri, Columbia - USA has shockingly found that intake of Nicotinamide Riboside (NR) dietary supplements (a form of Vitamin B3) actually increases the prevalence of cancers and also contributes to metastases formation in triple negative breast cancer (TNBC) even up to the brain!
The study also involved researchers from The Ludwig Institute for Cancer Research at the University of Lausanne – Switzerland, Nestlé Institute of Health Sciences - Switzerland, Swiss Federal Institute of Technology (EPFL), Lausanne - Switzerland and SwissLumix SARL, Lausanne - Switzerland.
Nicotinamide riboside (NR) is a form of vitamin B3 and is one of the most studied compounds for the restoration of cellular NAD+ levels demonstrating clinical potential in many metabolic and age-related disorders.
However, despite its wide commercial availability as a powerful nutraceutical, the current understanding of NR uptake by different cells and tissues is greatly limited by the lack of noninvasive in vivo imaging tools limiting its clinical translation.
The study team report the development and validation of a bioluminescent NR uptake probe (BiNR) for non-invasive longitudinal imaging of Nicotinamide riboside (NR) uptake both in vitro and in vivo.
In addition, the study team optimized an assay that allows monitoring of Nicotinamide riboside (NR) flux without the need to transfect cells with the luciferase gene, enabling the use of the BiNR probe in clinical samples, as demonstrated with human T cells.
The study team also used BiNR to investigate the role of NR uptake in cancer prevalence and metastases formation in triple negative breast cancer (TNBC) animal model. Our results demonstrate that Nicotinamide riboside (NR) supplementation results in a significant increase in cancer prevalence and metastases of TNBC to the brain.
The study finding cautions the important role of powerful nutraceuticals like Nicotinamide riboside (NR) in cancer metabolism and the need to personalize their use in certain patient populations.
The study findings were published in the peer reviewed journal: Biosensors and Bioelectronics.
Individuals have been using nicotinamide riboside supplements for claimed benefits for anti-aging effects, high cholesterol, high blood pressure, Alzheimer disease, obesity, and many other purposes although there is no hard scientific evidence to support these uses.
Worse, many aesthetic clinics around the world especially in Asia are promoting intravenous use of nicotinamide riboside among women and even men for skin lightening and also to deal with hyperpigmentation issues and for so called younger skin results.
The study team warns that the usage of nicotinamide riboside supplements should only be considered based on careful diagnosis and dircetives by qualified health professionals.
Its use in the pseudo-science based aesthetic and anti-aging applications promoted by unscrupulous doctors and charlatans should be stopped and in fact legal actions should be filed against such promoters.
Although past studies have linked commercial di
etary supplements like nicotinamide riboside (NR), a form of vitamin B3, to benefits related to cardiovascular, metabolic and neurological health, this new research findings has found that nicotinamide riboside (NR) could actually increase the risk of serious disease, including developing cancer.
The study team led by Dr Elena Goun, an associate professor of chemistry at University of Missouri, discovered high levels of nicotinamide riboside (NR) could not only increase someone's risk of developing triple-negative breast cancer, but also could cause the cancer to metastasize or spread to the brain. Once the cancer reaches the brain, the results are deadly because no viable treatment options exist at this time.
Dr Goun who is also the corresponding author told Thailand Medical News
, "Some individuals take vitamins and supplements because they automatically assume that vitamins and supplements only have positive health benefits, but very little is known about how they actually work. Because of this lack of knowledge, we were inspired to study the basic questions surrounding how vitamins and supplements work in the body."
Upon the death of her 59-year-old father only three months after being diagnosed with colon cancer, Dr Goun was moved by her father's passing to pursue a better scientific understanding of cancer metabolism, or the energy through which cancer spreads in the body. Since nicotinamide riboside (NR) is a known supplement for helping increase levels of cellular energy, and cancer cells feed off of that energy with their increased metabolism, Dr Goun wanted to investigate NR's role in the development and spread of cancer.
She added, "Our research is especially important given the wide commercial availability and a large number of ongoing human clinical trials where nicotinamide riboside or NR is used to mitigate the side effects of cancer therapy in patients.”
The study team used this technology to compare and examine how much nicotinamide riboside or NR levels were present in cancer cells, T cells and healthy tissues.
Dr Goun added, "Though nicotinamide riboside or NR is already being widely used in individuals and is being investigated in so many ongoing clinical trials for additional applications, much of how NR works is a black box - it's not well understood. Hence that inspired us to come up with this novel imaging technique based on ultrasensitive bioluminescent imaging that allows quantification of NR levels in real time in a non-invasive manner. The presence of NR is shown with light, and the brighter the light is, the more NR is present."
She said the study findings emphasize the importance of having careful investigations of potential side effects for supplements like nicotinamide riboside (NR) prior to their use in people who may have different types of health conditions.
The study team in the future would like to provide information that could potentially lead to the development of certain inhibitors to help make cancer therapies like chemotherapy more effective in treating cancer.
The main point to this approach, Goun said, is to look at it from a personalized medicine standpoint.
She stressed, "Not all cancers are the same in every person, especially from the standpoint of metabolic signatures. Often times cancers can even change their metabolism before or after chemotherapy."
This is the first study to date that has identified nicotinamide riboside supplementation as a cause of increased formation of brain metastases in TNBC mouse model.
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