Dutch And German Study Shows That SARS-CoV-2 Directly Infects The Kidneys And Causes Tissue Scarring Which Ultimately Leads To Kidney Damage And Failure!
Source: Medical News - COVID-19 Kidney Damage Dec 31, 2021 2 years, 3 months, 3 weeks, 5 days, 20 hours, 55 minutes ago
A new study by researchers from the Netherlands And Germany involving research entities like the RWTH Aachen University - Germany and Radboud University Medical Center - The Netherlands have found that the SARS-CoV-2 coronavirus is able to directly infect the human host kidneys and cause tissue scarring which ultimately culminates in kidney damage and failure.
To date, kidney failure is frequently observed during and after COVID-19, but it remains elusive whether this is a direct effect of the virus.
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The study team reports that SARS-CoV-2 directly infects kidney cells and is associated with increased tubule-interstitial kidney fibrosis in patient autopsy samples.
In order to study direct effects of the virus on the kidney independent of systemic effects of COVID-19, the study team infected human induced pluripotent stem cell-derived kidney organoids with SARS-CoV-2.
Single cell RNA-sequencing indicated injury and dedifferentiation of infected cells with activation of pro-fibrotic signaling pathways. Importantly, SARS-CoV-2 infection also led to increased collagen 1 protein expression in organoids.
Interestingly a SARS-CoV-2 protease inhibitor was able to ameliorate the infection of kidney cells by SARS-CoV-2.
The study findings suggest that SARS-CoV-2 can directly infect kidney cells and induce cell injury with subsequent fibrosis. These data could explain both acute kidney injury in COVID-19 patients and the development of chronic kidney disease in Long-COVID.
The study findings were published in the peer reviewed journal: Cell Stem Cell (Science Direct By Elsevier)
https://www.sciencedirect.com/science/article/pii/S1934590921005208
Thailand
Medical News would like to warn that the incidence of Chronic Kidney Damage (CKD) and Kidney Failure is growing exponentially among Long COVID patients who were deemed as recovered based on the protocols of using nasal or saliva swab test and the exhibition of no symptoms as a means of confirming recovery!
New emerging studies are showing that current COVID-19 diagnostics used to determine recovery is not reliable!
Worse, new studies are confirming the fact of viral persistence and organ attack by the virus for months after initial infection and deemed’ recovery’!
https://www.thailandmedical.news/news/breaking-u-s-nih-study-shockingly-reveals-sars-cov-2-viral-persistence-throughout-human-body-and-in-the-brain-even-in-those-who
-were-asymptomatic
The new study findings have confirmed that the SARS-CoV-2 coronavirus infects the kidneys and contributes to tissue scarring.
The developed scar tissue in the infected kidneys may suggest a possible impact on kidney outcomes in the long term.
Already the fact that the SARS-Cov-2 coronavirus can result in severe damage in the human body is known, and also that kidneys can get infected.
However, what exactly happens in the kidney as a result of the infection, remains elusive until now.
The study team investigated the kidney tissue of COVID-19 patients admitted to the Intensive Care Unit. They found scarring of the tissue as compared to Intensive Care patients with a non-COVID-19 lung infection and a control group.
Subsequently the study team questioned what exactly the cause was of the kidney damage. Could this be a direct effect of the virus, independent of systemic inflammation?
In order to investigate this, the study team cultured mini kidneys in the lab, called organoids. The kidney organoids are developed from stem cells and contain many different kidney cells, except immune cells. The kidney organoids were infected with SARS-CoV-2 and the study team investigated the direct effect of the virus on the kidney cells, independent of potential secondary effects caused by immune cells or other systemic effects.
The study team found, in line with the COVID-19 patient tissues, scarring of the kidney organoids and accompanied signals that contribute to the scarring process.
The study findings indicate that the recent finding of another USA based large cohort study that reported kidney functional decline in over 90,000 COVID-19 survivors might be due to direct effects of the SARS-CoV2 virus on the kidney causing scar formation.
https://jasn.asnjournals.org/content/32/11/2851
Lead researcher Dr Jitske Jansen from the Department of Pathology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center told Thailand
Medical News, “In our study, we thoroughly investigated the causal damaging effects of the Coronavirus in the kidneys. The infected kidney organoids show that the virus directly causes cell damage, independent of the immune system. With this work, we found a piece of the puzzle showing the deleterious effects the virus can have in the body.”
Co-researcher Dr Katharina Reimer from RWTH Aachen University added, “Kidney fibrosis, or scarring, is a serious long-term consequence that can occur virtually after any injury to the kidney and correlates with kidney function. Our work shows kidney scarring in COVID-19 patients, which provides an explanation why the virus might cause kidney functional decline as demonstrated in other studies. Long-term follow-up studies will provide further insights into kidney-related pathologies caused by SARS-CoV-2.”
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Thailand Medical News in the new year will be covering on studies that show certain herbs and phytochemicals can act as protease inhibitors to eradicate the virus from the kidney and also help in kidney tissue regeneration and also confer protective features for the kidneys. Keep on supporting our website to help you.
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https://www.thailandmedical.news/news/university-of-washington-study-confirms-that-sars-cov-2-can-directly-invade-human-kidney-cells-causing-a-range-of-kidney-issues-including-acute-kidney
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