Source: Generic Remdesivir Jul 06, 2020 3 years ago
Generic Remdesivir: The Trump administration last week proudly announced that it had secured 500,000 doses of Gilead’s remdesivir at prices that were set by Gilead at between US$2,340 to US$3,120. https://www.thailandmedical.news/news/breaking-remdesivir-gilead-sets-price-at-us$2,340-to-us$3,120-for-drug-that-has-no-safety-studies-or-true-efficacy-except-that-it-shortens-hospitaliza
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Source: SARS-CoV-2 Is Airborne Jul 06, 2020 3 years ago
WHO: Despite mounting evidence that the SARS-CoV-2 coronavirus is airborne and that the general public worldwide needs to be aware of this, the WHO (World Health Organization) is still taking a stance that it is not the case but is only spread by large respiratory droplets that, once expelled by infected people in coughs and sneezes, fall quickly to the floor.
The WHO lead by black ...
Source: COVID-19 Diagnostics Jul 05, 2020 3 years ago
COVID-19 Diagnostics: The US FDA last week on granted Emergency Use Authorization to a new molecular diagnostic test from the US Centers for Disease Control and Prevention that can detect and differentiate the viruses that cause COVID-19 and flu.
The new Influenza SARS-CoV-2 (Flu SC2) Multiplex Assay is a real-time RT-PCR test intended for the simultaneous detection and differ...
Source: COVID-19 Innovations Jul 05, 2020 3 years ago
COVID-19 Innovations: The current COVID-19 pandemic has brought a slew of new challenges for clinical facilities, including how to deliver as much care as possible at a distance or remotely not only for precautionary measures to safeguard the wellbeing of healthcare staff but only for better monitoring of COVID-19 patients..
Researchers from the Department of Cardiovascular Medicine at To...
Autoimmunity: In normal roles, the immune system is supposed to protect from external microbial invaders, but sometimes it turns its efforts inward, potentially resulting in autoimmune diseases.
Researchers from Osaka University In a new study have discovered how reversible modifications to DNA by certain proteins protect from autoimmune diseases, and conversely, how the absence of these ...
COVID-19 And HIV: Individuals with HIV who were hospitalized with COVID-19 did not have worse results than COVID-19 patients without HIV, according to new research by Icahn School of Medicine at Mount Sinai.
The research findings were published in the journal: Clinical Infectious Diseases https://academic.oup.com/cid/article/doi/10.1093/cid/ciaa880/5864410?searchresult=1
Study...
COVID-19 Pharma News: Pharma giant Merck, a leading science and technology company, announced that the US FDA has cleared its investigational new drug application (IND) for M5049 for the treatment of patients with Covid-19 pneumonia. Merck will initiate a Phase II randomized, controlled clinical study evaluating the safety and efficacy of M5049 in this patient population. M5049 is a potentially fi...
Source: Melatonin and COVID-19 Jul 05, 2020 3 years ago
Melatonin and COVID-19: Another study by researchers from Peking Union Medical College in China and the University of Texas- San Antonio in America have in a new peer-reviewed finding that is published in the journal: Life Sciences By Science Direct, propose that Melatonin should be incorporated as an adjuvant treatment for COVID-19 as it has proven mechanisms to target Inflammasomes that triggers...
COVID-19 Vaccine: Researchers from China have created an artificial protein that they say could be the basis of a vaccine to help ward off various deadly coronaviruses, including the pathogen that causes Covid-19
Copyright: Credit: Xinhua
The researchers from the Chinese CDC said the approach triggered a strong antibody response in mice and monkey trials to Middle Eas...
Source: COVID-19 Clinical Care Jul 04, 2020 3 years ago
COVID-19 Clinical Care: Researchers are expressing that more safety data is needed in terms of treatment of symptomatic COVID-19 patients on antivirals with anticancer drugs.
A report published in the European Journal of Cancer by a group of French investigators led by Dr Paul Gougis of the Department of pharmacology, Hôpital Pitié-Salpêtrière in Paris, Franc...
COVID-19 Drugs: EUSA Pharma has secured approval from the U.S. Food & Drug Administration (FDA) for a Phase III clinical trial protocol of intravenous siltuximab plus standard of care in hospitalized patients with Covid-19 associated Acute Respiratory Distress Syndrome (ARDS).
The pharmaceutical company will now proceed with the randomized, double-blind, placebo-controlled clinical trial to e...
COVID-19 Vaccine: Indian pharmaceutical company, Zydus Cadila received the green signal from the Drug Controller General of India (DGCI) to start phase I and II of their clinical trials on human participants.
Over 120 independent scientific bodies are in contention to find a potential COVID-19 vaccine. Over 7 vaccines are being researched in India and just this week, two candidate groups ...
Source: Thailand Medical News Jul 04, 2020 3 years ago
The human brain has a high energy demand and reacts very sensitively to oxygen deficiency. Ludwig Maximilian University of Munich neurobiologists have now succeeded for the first time in directly correlating oxygen consumption with the activity of certain nerve cells.
Typically, the brain requires a disproportionate amount of energy compared to its body mass. This energy is mainly generat...
HIV Drugs: The drug Rukobia (fostemsavir) has been approved by The U.S. FDA for adults living with HIV who have tried multiple HIV medications and whose HIV infection cannot be successfully treated with other therapies because of resistance, intolerance or safety considerations.
Rukobia (Fostemsavir) is a new type of antiretroviral medication to be taken twice daily by mouth. It is a prodrug, whi...
Source: COVID-19 Vaccine Updates Jul 04, 2020 3 years ago
COVID-19 Vaccine Updates: Pharmaceutical and Biotech giants, Pfizer and BioNTech reported that the most advanced of four constructs of their messenger RNA (mRNA) vaccine candidate for COVID-19 showed encouraging immunogenicity and a favorable safety profile in preliminary Phase I/II data published in a preprint study. https://www.medrxiv.org/content/10.1101/2020.06.30.20142570v1
Bot...
Source: COVID-19 Disinfectants Jul 04, 2020 3 years ago
COVID-19 Disinfectants: University of Manchester scientists say that a little-known non-toxic antiseptic developed in the Soviet Union during the Cold War has enormous potential to beat common infections and that even detailed studies should be conducted with regards to its use in the current COVID-19 scenario. Their report was published in the journal: FEMS Microbiology Reviews. https://aca...
Source: Chronic Fatigue Syndrome Jul 04, 2020 3 years ago
Chronic Fatigue Syndrome: There has been so many clinical manifestation of Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) reported in COVID-19 patients experiencing mild to moderate symptoms and also in typically asymptomatic and also recovered COVID-19 patients. To date medical experts do not have a proper explanation for this.
However, browsing through various new COVI...
Source: COVID-19 Research Jul 04, 2020 3 years ago
COVID-19 Research: Researchers from the University Of Bristol in a new review published in the Journal Of Infection indicate that liver complications are common and are associated with more severe disease in patients with COVID-19. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306105/ or https://www.journalofinfection.com/article/S0163-4453(20)30425-4/pdf
Dr Setor K. Kunutsor of Bristol M...
Source: COVID-19 Pediatrics Jul 04, 2020 3 years ago
COVID-19 Pediatrics: Researchers from the University College London Institute of Neurology are warning that children with COVID-19 may present with new neurological symptoms involving the central and peripheral nervous systems, and splenial changes on imaging.
The new research findings were published the journal: JAMA Neurology.
https://jamanetwork.com/journals/jamaneurology/fullarticle/2...
COVID-19 Drugs and Erythropoietin: German researchers from the Max Planck Institute of Experimental Medicine in Göttingen suggest that the anemia drug Erythropoietin (Epo) which is sometimes misused as doping agent could also be effective against COVID-19.
EPO, the growth factor could also mitigate severe disease progression and protect patients from long-term neurological effects when the ...
Source: SARS-COV-2 Mutations Jul 03, 2020 3 years ago
SARS-COV-2 Mutations: Virologists and genomic researchers now know that two major variants of the novel coronavirus (SARS-CoV-2) are circulating in the United States and elsewhere at the moment besides the hundreds of minor variants. The variants, called G614 and D614, have just a small difference in their "spike" protein, the viral machinery that coronaviruses use to enter hos...
Source: U.S. COVID-19 News Jul 03, 2020 3 years ago
U.S. COVID-19 News: America sets a new record in the last 24 hours with 53,069 (Thursday) new coronavirus infections in the last 24 hours. The country now has recorded a total of 2,837,189 COVID-19 Infections of which health authorities claim that 1,191,102 have ‘recovered.’ A total of 131,217 Americans have died from the COVID-19.
What is even scarier is that it is reported t...
Source: COVID-19 Diagnostics Jul 03, 2020 3 years ago
COVID-19 Diagnostics: Despite the fact that accurate and widespread testing is crucial to managing the coronavirus pandemic, many individuals in the U.S. and even elsewhere globally still can’t get tested for COVID-19 without visiting designated sites.
A rendering of a potential affordable, handheld COVID-19 testing device.
The researchers hope to be evaluating prototyp...
COVID-19 Drugs: Researchers from the University of North Carolina (UNC) have used a new web-based platform to help identify synergistic and antagonistic drug combinations and their underlying mechanisms of action in the context of fighting the SARS-CoV-2 coronavirus disease.
The data mining tool, called COVID-KOP, prioritized 73 combinations of 32 drugs as potential treatments for COVID-1...
Source: COVID-19 and Strokes Jul 03, 2020 3 years ago
COVID-19 and Strokes: A new study finds that although both Influenza and COVID-19 can raise the risk for a stroke, the odds appear to be eight times higher with the SARS-CoV-2 coronavirus.
The researchers found that among more than 1,900 patients with COVID-19, 1.6% suffered a stroke, versus 0.2% of nearly 1,500 patients seriously ill with flu.
The research findings ...
COVID-19 Hypoxia: Researchers from Hines Veterans Affairs Hospital and Loyola University of Chicago in a new study provides possible explanations for COVID-19 patients who present with extremely low, otherwise life-threatening levels of oxygen, but no signs of dyspnea (difficulty breathing). This new understanding of the condition, known as silent hypoxemia or 'happy hypoxia,' could ...
Source: COVID-19 and the Endocrine System Jul 02, 2020 3 years ago
COVID-19 Endocrine System: It seems that the damage from the SARS-CoV-2 coronavirus is never ending. Starting out initially as a respiratory disease that causes damage to the lungs, studies progressed to show that it also affects the immunity system, the gastroenterological system, the clotting mechanisms, the neurological system, the heart and circulatory system, the reproductive system in males ...
Source: HIV and Lenacapavir Jul 02, 2020 3 years ago
HIV and Lenacapavir: Gilead scientists are reporting an early step toward an HIV drug that could potentially be taken only a couple of times per year.
A new study showed that a single injection of the experimental drug, called lenacapavir, was able to lower blood levels of HIV in a small group of patients. And it was capable of maintaining active levels in the blood for more than six...
Source: Skin Inflammation Jul 02, 2020 3 years ago
Skin Inflammation: Researchers from Ohio State University Wexner Medical Center have demonstrated in animal models using mice that diets rich in black raspberries can reduce inflammation associated with skin allergies.
The research findings were published in the journal: Nutrients https://www.mdpi.com/2072-6643/12/6/1701
The study showed that black raspberries reduced inf...
Source: Antibiotics and Microbiome Jul 02, 2020 3 years ago
Antibiotics: Researchers from the University Of Melbourne and Baylor College of Medicine-Texas have found in a new study that antibiotic exposure during crucial developmental periods in early childhood alters digestive tract nerve function and bacterial colonies.
The research finds are published in the American Journal of Physiology-Gastrointestinal and Liver Physiology. https://jour...
Source: COVID-19 Recovered Patients Jul 02, 2020 3 years ago
COVID-19 Recovered Patients: A collaborative study in China involving leading universities and hospitals headed by Wuhan Institute Of Virology has discovered that recovered patients who even after 2 to 11 weeks of being discharged from hospitals, displayed a remarkable phenotypic alterations in lymphocytes after clinical recovery. This suggests SARS-CoV-2 infection imprints profoundly on lymphocyt...
Source: Diabetes and COVID-19 Jul 02, 2020 3 years ago
Diabetes And COVID-19: A case study by German researchers from University of Kiel have confirmed that the Sars-CoV-2 coronavirus can trigger diabetes and insulin dependency in young adults who have otherwise been healthy with any prior history of sickness or diabetes. It is assumed that the diabetes is triggered by the SARS-CoV-2 coronavirus attacking the pancreas thru the ACE-2 receptors present ...
Source: COVID-19 Diagnostics Jul 02, 2020 3 years ago
COVID-19 Diagnostics: Researchers from the Innovative Genomics Institute (IGI), the same UC Berkeley group that rapidly popped up a state-of-the-art COVID-19 testing laboratory in March, are now trialing a quicker way to obtain patient samples: through saliva.
So far diagnostic tests for COVID-19 have relied on samples obtained by swabbing uncomfortably deep into a person’s nasal pa...
US Medical News: Daily new COVID-19 cases in America soared past 51,097 in the last 24 hours for the first time, as the World Health Organization delivered a grave warning that the global pandemic is accelerating.
Clubs, restaurants, bars and beaches in the world's worst-hit nation closed from California to Florida, as states reeling from yet another surge in the deadly virus&nbs...
COVID-19 Latest: Researchers from Utrecht University, UMC Utrecht, and Erasmus MC have discovered that platelets also play a role in the immune system: They appear to be indispensable in protecting the respiratory system against pathogens despite their primary role in blood coagulation and the development of thrombosis.
Lead researcher Dr Erhard van der Vries told Thailand Medical News, &...
COVID-19 Vaccine: Members of the National Institutes of Health's Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) Vaccines Working Group assess practical considerations and prerequisites for using controlled human infection models (CHIMs), which can be used for human challenge studies, to support SARS-CoV-2 vaccine development.
In a new report published in th...
Source: COVID-19 Drugs and Fostamatinib Jul 02, 2020 3 years ago
COVID-19 Drugs: Fostamatinib, an FDA-approved monoclonal antibody that is a spleen tyrosine kinase inhibitor (SYK), was studied by researchers from Harvards’ Broad Institute, Imperial College’s Hammersmith Hospital, Brigham and Women’s Hospital and Harvard Medical School for possible use to reduce the levels of mucin-1, a molecule associated with acute lung injury and acute respi...
Source: COVID-19 Endotheliopathy Jul 02, 2020 3 years ago
COVID-19 Endotheliopathy: Yale University researchers have found that injury to endothelial cells ie the cells lining blood vessels may be a key driver of COVID-19 severity and death.
The new research may help to explain the mysterious blood clotting seen in some patients with COVID-19, a condition associated with the most severe cases and death. The discovery suggests that doctors could ...
Source: COVID-19 Antibodies Jul 02, 2020 3 years ago
COVID-19 Antibodies: A new research published by the British Medical Journal, (BMJ) yesterday highlights major weaknesses that exist in the evidence base for COVID-19 antibody tests. https://www.bmj.com/content/370/bmj.m2516
The research found that the evidence is particularly weak for point-of-care tests (performed directly with a patient, outside of a laboratory) and does not support...
Source: World Covid-19 News Jul 01, 2020 3 years ago
World Covid-19 News: The world has recorded 10,614,957 official COVID-19 infections and 514,635 deaths in the last six months as of Ist July 2020 (5am California). The actual figures are at least 5 fold for both infection and deaths due to underreporting and concealments by many countries. Unfortunately despite the relative high figures, people are still complacent and many are living in denial. (...
Source: COVID-19 Disinfectants Jul 01, 2020 3 years ago
COVID-19 Disinfectants: PNNL or Pacific Northwest National Laboratory has created a new superhydrophobic material, called ElastiDry that repels bacteria and viruses.
Water beads off ElastiDry due to the substance’s superhydrophobocity.
Image credit: Andrea Starr | PNNL
PPEs or personal protective equipment has been at the center of the fight against COVID-19. The unforgiving...
COVID-19 Vaccine: Medical experts from UK are saying that a vaccine against COVID-19 may not be as effective in older people who are most at risk of suffering complications and dying from the disease.
A better approach they say is to immunize those around the elderly to better help them and also protect them from getting infected those close to them or are in constant with them.
Pr...
Source: COVID-19 Clinical Trials Jul 01, 2020 3 years ago
COVID-19 Clinical Trials: Researchers from RCSI University of Medicine and Health Sciences-Ireland have begun a clinical trial of a promising therapy for critically ill COVID-19 patients in intensive care.
A study published in the American Journal of Respiratory and Critical Care Medicine by the team led by RCSI Professors Dr Gerry McElvaney and Dr Ger Curley, describe changes in the...
Source: COVID-19 Neurology Jul 01, 2020 3 years ago
COVID-19 Neurology: A research team comprising of multidisciplinary experst from two Johns Hopkins University institutions, including neurotoxicologists and virologists from the Bloomberg School of Public Health and infectious disease specialists from the school of medicine, has found that organoids (tiny tissue cultures made from human cells that simulate whole organs) known as "mini-brains&...
Source: COVID-19 Genomics Jul 01, 2020 3 years ago
COVID-19 Genomics: Genomic researchers from Norway and the US demonstrate the presence of a highly conserved, mobile genetic element (thus far with unknown function) in genomes of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and a large number of insects, opening the door for hitherto unexplored treatment opportunities.
The coronaviruses are a group of known human...
COVID-19 Drugs: The SARS-CoV-2 coronavirus typically uses a protein called polymerase to replicate its genome inside infected human cells. Studies have shown that terminating the polymerase reaction will stop the growth of the coronavirus, leading to its eradication by the human host's immune system.
Now researchers from Columbia University and the University of Wisconsin-Madison have...
Source: COVID-19 Myocarditis Jul 01, 2020 3 years ago
COVID-19 Myocarditis: Researchers from Mount-Sinai have in a new study showed that the SARS-CoV-2 coronavirus can infect heart cells in a lab dish, indicating it may be possible for heart cells in COVID-19 patients to be directly infected by the virus.
The new discovery, published in the journal Cell Reports Medicine, was made using heart muscle cells that were produced by stem cell ...
Source: New G4 EA H1N1 Swine Flu Strain Jun 30, 2020 3 years ago
New G4 EA H1N1 Swine Flu Strain: A team of researchers affiliated with a host of institutions in China and one in the U.S. has found evidence of a new strain of swine flu that poses a possible threat to humans based on widespread testing of pigs in China and people known to be near them.
The research finds are published in the journal: Proceedings of the National Academy of Sciences...
COVID-19 Drugs: More emerging results from the ongoing international RECOVERY Trail project shows that Lopinavir-Ritonavir has no clinical benefits in hospitalized COVID-19 treatments. Readers should also take note that in February 2020, Thai ‘medical experts’ held a huge press conference to announce that they had invented a treatment protocol to treat COVID-19 using Lopinavir-Ritonavi...
Source: COVID-19 Research Jun 30, 2020 3 years ago
COVID-19 Research: A new research by University Of Utah indicates that changes in blood platelets triggered by COVID-19 could contribute to the onset of heart attacks, strokes, and other serious complications in some patients who have the disease.
The study team found that inflammatory proteins produced during infection significantly alter the function of platelets, making them "hype...
Health Tips: According to a new study from researchers at the University of California-Davis, raw or unpasteurized cows' milk from U.S. retail stores can hold a huge amount of antimicrobial-resistant genes if left at room temperature, The research also found bacteria that harbored antimicrobial-resistant genes can transfer them to other bacteria, potentially spreading resistance if consumed.
...
Source: Multisystem Inflammatory Syndrome Jun 30, 2020 3 years ago
Multisystem Inflammatory Syndrome: Till May 2020, at least 285 children in America alone have developed a serious inflammatory condition linked to the SARS-Cov-2 coronavirus and while most recovered, the potential for long-term or permanent damage is unknown, two new studies published in the New England Journal of Medicine suggest. These are the most detailed reports yet on the condition.
https://...
Source: COVID-19 Research Jun 30, 2020 3 years ago
COVID-19 Research: Researchers from University of Utah Health and PEEL Therapeutics, in collaboration with Cold Spring Harbor Laboratory and Weill Cornell Medicine, report in a new study that an overactive defense response may lead to increased blood clotting, disease severity, and death from COVID-19. A phenomenon called NETosis in which infection-fighting cells emit a web-like substance to trap ...
Source: PTSD and COVID-19 Jun 30, 2020 3 years ago
PTSD: The COVID Trauma Response Working Group, which includes mental health experts from King’s College London, University College London, Oxford University, the University of Haifa in Israel, and the NHS, are warning that those who have been admitted in intensive care units or even just hospitalized for COVID-19, would have been seriously ill enough to develop PTSD (post-traumatic str...
Source: Health Tech Startups Jun 30, 2020 3 years ago
Health Tech Startups: A team of National University Of Singapore (NUS) researchers have developed a portable COVID-19 micro-PCR diagnostic system called Epidax that enables rapid and accurate on-site screening of infectious diseases and significantly reduces the time required to analyze patient samples. With this new innovation COVID-19 screening can soon be conducted directly at various testing s...
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