Contrary To Misinformation, COVID-19 Mortality And Hospitalization Has Been Rising In The Last 30 Days Globally. Please Take Precautions!

BREAKING NEWS
COVID-19 News - hypoalbuminemia  Jan 14, 2023  15 days ago
BREAKING! COVID-19 News: SARS-CoV-2 That Causes Liver Impairment In Many Also Causes Hypoalbuminemia!
2786 Shares
facebook sharing button Share
twitter sharing button Tweet
linkedin sharing button Share
BREAKING! COVID-19 News: SARS-CoV-2 That Causes Liver Impairment In Many Also Causes Hypoalbuminemia!
COVID-19 News - hypoalbuminemia  Jan 14, 2023  15 days ago
COVID-19 News: A new meta-analysis study by researchers from Department of Hepatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou-China and  Mei-Zhu Hong, Department of Traditional Chinese Medicine, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou-China on the liver chemistries of severe or non-severe patients of COVID-19 has revealed interesting insights into varying degrees of liver impairment that SARS-CoV-2 infections can cause and also possibly contribute to Long COVID.


 
The study findings showed that individuals with severe cases of COVID-19 infections tend to have higher gamma-glutamyltransferase (GGT) levels in blood test. High levels of GGT in the blood is a reflection of liver disease or damage to the bile ducts. Bile ducts are tubes that carry bile in and out of the liver.
 
The study findings also showed that severe infections also lead to low levels of albumin or what is known as hypoalbuminemia.
 
Thailand Medical News would like to add that symptoms of hypoalbuminemia include the following:
 
-Fatigue.
-Weak muscle tone.
-Jaundice.
-Swelling in their feet and legs.
-Dark-colored urine and/or frequent urination.
-Difficulty breathing.
-Loss of appetite.
 
It has been found that some of those severe cases who recovered had these symptoms in Long COVID manifestations and there is a possibly that hypoalbuminemia is also contributing to some of the Long COVID conditions.
 
The study team from China sought to provide a comprehensive analysis of liver test parameters in patients with severe and non-severe COVID-19.
 
The researchers performed a detailed meta-analysis of published liver manifestations and described the liver damage in COVID-19. They searched PubMed, Google Scholar, Embase, Cochrane Library, medRxiv, bioRxiv, and three Chinese electronic databases through April 18, 2020, in accordance with the Preferred Reporting Items for Meta-Analyses.
 
The study team then analyzed pooled data on liver chemistries stratified by COVID-19 severity using a fixed or random-effects model.
 
The study findings form the detailed meta-analysis of 56 studies, including 11052 patients, found that the pooled mean alanine aminotransferase (ALT) in severe COVID-19 cases was 35.9 IU/L whereas in non-severe COVID-19 cases was 27.3 IU/L. Average aspartate aminotransferase (AST) levels were 44.3 IU/L in severe cases compared to 27.9 IU/L in non-severe cases. In addition, AST levels are often higher than ALT levels regardless of disease severity.
 
Most importantly, the severe cases tended to have a higher gamma-glutamyltransferase (GGT) level but a lower albumin level than the non-severe cases.
 
The study findings concluded that severe COVID-19 was more likely to be associated with abnormal liver test results. Monitoring liver chemistry closely can help detect disease progression early.
 
The study findings were published in the peer reviewed World Journal of Hepatology.
https://www.wjgnet.com/1948-5182/full/v14/i12/2012.htm
 
An earlier Spanish study had already found the SARS-CoV-2 spike 1 subunit is also able to bind to albumin and contribute to disease severity.
https://pubmed.ncbi.nlm.nih.gov/35160039/
 
A study by researchers from UK and Iraq showed persistent levels of hypoalbuminemia in recovered patients.
https://onlinelibrary.wiley.com/doi/epdf/10.1002/jmv.27002
 
Studies have also emerged that even those with mild symptomatic COVID-19 infections also exhibit hypoalbuminemia.
https://pesquisa.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/pt/covidwho-1915663
 
Studies have also emerged that even children with mild COVID-19 are also developing hypoalbuminemia.
https://europepmc.org/article/pmc/8013663
 
While many studies have focused on hypoalbuminemia to determine disease progression into severity, not much research have focused on persistent levels of hypoalbuminemia in asymptomatic, mild and all Post COVID-19 individuals.
https://ccforum.biomedcentral.com/articles/10.1186/s13054-020-02995-3
 
https://www.sciencedirect.com/science/article/pii/S2405457721002473
 
https://www.dovepress.com/hypoalbuminemia--an-indicator-of-the-severity-and-prognosis-of-covid-1-peer-reviewed-fulltext-article-IDR
 
We at Thailand Medical News believes that the persistent hypoalbuminemia is affecting many Post-COVID-19 individuals irrespective of their initial conditions upon exposure to the virus and more some also believe without substantial evidence yet that the some of the new SARS-CoV-2 subvariants and sub-lineages that have been in circulation since Jun2 2022 are also displaying more tropism to the liver tissues and cells as well.
https://www.thailandmedical.news/news/are-the-new-sars-cov-2-variants-circulating-in-europe-more-neuropathogenic-with-a-modified-pathogenesis-brain-and-liver-issues-on-the-rise
 
We have already covered extensive in our past COVID-19 News coverages that SARS-CoV-2 infections not only lead to liver impairment and acute liver injury but also contributes to the possibility of liver cancer, fatty liver disease and other dangerous liver conditions.
https://www.thailandmedical.news/news/breaking-study-finds-that-upregulated-interleukin-6-drives-development-of-rare-liver-cancers-covid-19-infections-causes-elevated-il-6-levels-in-many
 
https://www.thailandmedical.news/news/researchers-alarmingly-find-that-metabolic-associated-fatty-liver-disease-mafld-may-be-a-prevalent-long-covid-manifestation
 
https://www.thailandmedical.news/news/breaking-sars-cov-2-infection-induces-increase-of-gp73-that-causes-dysglycaemia-increased-gp73-could-also-imply-future-liver-disease-and-liver-cancer
 
https://www.thailandmedical.news/news/belgium-researchers-warn-that-more-hospitalized-covid-19-patients-are-manifesting-a-rare-chronic-liver-disease-known-as-sclerosing-cholangitis-could-b
 
https://www.thailandmedical.news/news/coronavirus-news-german-study-confirms-that-sars-cov-2-coronavirus-can-invade-and-damage-the-liver
 
https://www.thailandmedical.news/news/breaking-covid-19-research-studies-warn-of-high-prevalence-of-liver-injury-in-covid-19-patients
 
https://www.thailandmedical.news/news/covid-19-research-university-of-bristol-researchers-warn-that-liver-complications-are-common-in-covid-19-patients
 
More urgent studies are needed on hypoalbuminemia and long COVID as many researchers and even physicians could be missing out on yet one of the many factors contributing to Long COVID.
 
For the latest COVID-19 News, keep on logging to Thailand Medical News.
 
Read Also
https://www.thailandmedical.news/news/covid-19-drugs-latest-japanese-study-shows-association-between-high-serum-favipiravir-concentrations-and-drug-induced-liver-injury
 

MOST READ

Sep 25, 2022  4 months ago
Source: Medical News - SARS-CoV-2 Fall And Winter 2022 Variant Collections
Sep 08, 2022  5 months ago
Source- Medical News - COVID-19 Research - Impaired Pain Modulation
Aug 04, 2022  6 months ago
Source: Medical News - SARS-CoV-2 & Cancer
Aug 13, 2020  2 years ago
Source: Supplements For COVID-19
Feb 05, 2020  3 years ago
Source : Thailand Medical news