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Source: APOE4-COVID-19  Dec 28, 2021  2 years, 3 months, 3 weeks, 12 minutes ago

University Of Helsinki Study Shows APOE4 Allele Gene More Than Doubles Risk Of Severe COVID-19 Besides Increasing COVID-19 Cerebral Microhemorrhages!

University Of Helsinki Study Shows APOE4 Allele Gene More Than Doubles Risk Of Severe COVID-19 Besides Increasing COVID-19 Cerebral Microhemorrhages!
Source: APOE4-COVID-19  Dec 28, 2021  2 years, 3 months, 3 weeks, 12 minutes ago
APOE4-COVID-19: Researchers from the University of Helsinki-Finland have discovered in a new study that the APOE4 allele gene more than doubles risk of severe COVID-19 besides increasing cerebral microhemorrhages related to COVID-19.


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The study team also found that gene is also associate with mental fatigue related to long COVID or PASC (Post-acute Sequelae of COVID-19).
 
The Apolipoprotein E ε4 allele (APOE4) has been shown to associate with increased susceptibility to SARS-CoV-2 infection and COVID-19 mortality in some previous genetic studies, but information on the role of APOE4 on the underlying pathology and parallel clinical manifestations is scarce.
 
The research team studied the genetic association between APOE and COVID-19 in Finnish biobank, autopsy and prospective clinical cohort datasets. In line with previous work, the data on 2611 cases showed that APOE4 carriership associates with severe COVID-19 in intensive care patients compared with non-infected population controls after matching for age, sex and cardiovascular disease status.
 
In addition, histopathological examination of brain autopsy material of 21 COVID-19 cases provided evidence that perivascular microhaemorrhages are more prevalent in APOE4 carriers.
 
The study team’s analysis of post-COVID fatigue in a prospective clinical cohort of 156 subjects revealed that APOE4 carriership independently associates with higher mental fatigue compared to non-carriers at six months after initial illness.
 
The study findings suggest that APOE4 is a risk factor for severe COVID-19 and post-COVID mental fatigue and provides the first indication that some of this effect could be mediated via increased cerebrovascular damage. Further studies in larger cohorts and animal models are warranted.
 
The study findings were published in the peer reviewed journal: Acta Neuropathologica Communications (Springer)
https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-021-01302-7
 
Approximately one-third of Finns carry the APOE4 allele, a genetic variant that predisposes carriers to Alzheimer's disease.
 
Worldwide, about 25% of people carry one copy of APOE4, and 2 to 3% carry two copies. APOE4 is the strongest risk factor gene for Alzheimer’s disease, although inheriting APOE4 does not mean a person