South Korean Scientists Discover That Extracellular Vesicles Of The Microlagae Euglena Gracilis Aids In Skin Regeneration And Wound Healing
: In an extraordinary breakthrough study, South Korean researchers from Sungkyunkwan University, Ewha Womans University and STechnology Innovation Center have discovered that a product derived from the freshwater single-celled green algae, Euglena gracilis, has the potential to accelerate skin regeneration and wound healing.
The study highlights the development of an innovative system using microvesicles originating from the surface of Euglena gracilis cells. These microvesicles contain β-glucan, a carbohydrate known to regulate the immune system, promote regeneration, and exhibit antioxidant properties.
In a series of laboratory experiments, these microvesicles were found to enhance the proliferation and migration of skin cells, significantly boosting collagen synthesis and the expression of proliferation-associated proteins.
A subsequent wound healing test also produced promising results, demonstrating the considerable potential of this Euglena gracilis-derived extracellular microvesicle (EMVEG) system in the field of skin regeneration.
The authors of the study foresee the application of this technique to other cells, leading to the design of novel extracellular vesicles for skin treatments and care in the pharmaceutical and cosmetic industries and in the field of Aesthetics.
The EMVEG system, based on microalgae-containing carbohydrate bioactives, was developed by optimizing the particle size of the microvesicles at around 1 µm to maximize the encapsulation yield of β-1,3-glucan and enhance cellular delivery performance.
In vitro and cell scratch assays showed that EMVEG promoted the proliferation and migration of skin cells, leading to increased collagen synthesis and the expression of proliferation-associated proteins.
Ex vivo wound-healing tests using both artificial and porcine skin revealed that EMVEG could substantially increase the cell population expressing the proliferation-related protein, proliferating cell nuclear antigen (PCNA), similarly to β-1,3-glucan.
The study also emphasized the potential of extracellular vesicles (EVs) as a therapeutic tool for medical purposes.
Extracellular vesicles, such as exosomes, can be directly transferred into the body to alleviate symptoms or suppress the progression of diseases and repair or regenerate damaged tissues and organs.
Despite their therapeutic advantages, the widespread use of exosomes has been limited due to issues with standardization and contamination. The development of the EMVEG system addresses these challenges, offering a scalable production process based on cell extrusion using Euglena gracilis as the origin.
By employing a modified cell extrusion process, the study team demonstrated that pressure-mediated Euglena gracilis rupturing and subsequent reassembly of cell membrane fragments resulted in the efficient production of EMVEG. The particle size of EMVEG was adjusted to around 1 µm while maintaining a typical vesicular morphology. Both in vitro and ex vivo tests showed that EMVEG exhibited excellent skin regeneration perf
ormance, enhancing the expression of related proteins through favorable cellular uptake of β-glucan.
This groundbreaking study paves the way for the development of new types of non-animal-derived extracellular vesicle systems for skin treatments and care in the pharmaceutical and cosmetic industries. The innovative EMVEG system, harnessing the power of algae, could revolutionize the way we approach skin regeneration and wound healing, offering a natural and effective solution to these common challenges.
The study findings were published in the peer reviewed journal: Advanced Materials Interfaces.
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