Nikhil Prasad Fact checked by:Thailand Medical News Team Nov 11, 2025 2 hours, 58 minutes ago
Medical News: Natural Power of Black Chokeberry
A team of researchers from the A.E. Arbuzov Institute of Organic and Physical Chemistry at the Kazan Scientific Center, Russian Academy of Sciences, has discovered that tannins extracted from the fruits of Aronia melanocarpa—commonly known as black chokeberry—can effectively protect the body from oxidative stress and immune dysfunction caused by chemotherapy drugs such as cyclophosphamide. These natural compounds, known as polyphenols, have been found to not only combat free radicals but also support the immune system and aid in blood recovery.
Aronia Tannins Found to Shield Body from Chemotherapy Damage
A Breakthrough in Natural Antioxidant Therapy
The scientists isolated a highly purified tannin fraction from chokeberry fruits using advanced laboratory techniques. They compared the antioxidant and immune-restoring abilities of these tannins with well-known compounds such as quercetin, ascorbic acid (vitamin C), and Trolox. Remarkably, the chokeberry tannins showed strong free radical neutralization capacity and even greater membrane-protective effects than the reference antioxidants. This
Medical News report reveals that when tested on rats exposed to the chemotherapy drug cyclophosphamide, the tannins helped prevent oxidative damage to cells, reduced toxic byproducts in the blood, and restored immune and blood cell levels more effectively than other antioxidants.
How Aronia Tannins Protect the Body
The study demonstrated that these natural tannins act as powerful defenders against oxidative stress, which occurs when harmful molecules called free radicals attack healthy cells. Researchers noted that within two to three weeks after treatment, the animals given Aronia tannins had 1.7 times lower levels of malondialdehyde (a marker of oxidative damage) than untreated ones. Additionally, their white blood cell and platelet counts recovered faster, suggesting that these compounds helped the bone marrow regenerate after chemotherapy-induced damage.
The tannins also played a dual role in immune regulation. They selectively activated monocytes (a type of white blood cell that engulfs bacteria) while preventing excessive activation of neutrophils, thus maintaining a balanced immune response. This helped ensure effective bacterial clearance without causing tissue damage from inflammation.
A Safe and Promising Natural Option
Unlike synthetic drugs that often have severe side effects, the Aronia tannin extract provided a gradual but lasting protective effect with minimal toxicity. The findings indicate that these compounds can stabilize cell membranes, prevent red blood cell breakdown, and support the body’s natural antioxidant defenses. Researchers emphasized that the Aronia tannin fraction acts in harmony with the body’s internal defense systems by activating genes responsible for antioxidant enzyme production, helping restore balance after oxidative injury.
Conclusion
The researchers conc
luded that tannins derived from Aronia melanocarpa hold immense potential as natural therapeutic agents to counteract chemotherapy-related toxicity, boost immune recovery, and improve overall resilience to oxidative stress. Their ability to simultaneously protect cell membranes, enhance immunity, and stimulate blood regeneration could make them valuable in future supportive treatments for patients undergoing cancer therapy. The findings highlight a new way nature’s compounds can complement modern medicine safely and effectively.
The study findings were published in the peer reviewed journal: Molecules.
https://www.mdpi.com/1420-3049/30/22/4338
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