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Source: Medical News - SARS-CoV-2-Male-Testes  Feb 08, 2022  1 year, 9 months, 3 weeks, 2 days, 14 hours, 47 minutes ago

BREAKING! Brazilian And American Study Discovers That The Testes Of Males Could Be Viral Sanctuaries For The SARS-CoV-2 Virus!

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BREAKING! Brazilian And American Study Discovers That The Testes Of Males Could Be Viral Sanctuaries For The SARS-CoV-2 Virus!
Source: Medical News - SARS-CoV-2-Male-Testes  Feb 08, 2022  1 year, 9 months, 3 weeks, 2 days, 14 hours, 47 minutes ago
Alarming findings from a new study by researchers from Universidade Federal de Minas Gerais-Brazil, University of Texas Medical Branch-USA, University of Pittsburgh School of Medicine-USA, Faculdade de Medicina de São Jose do Rio Preto-Brazil, Universidade Estadual Paulista-Brazil and  Clínica MF Fertilidade Masculina-Brazil shows that the SARS-CoV-2 infects, replicates, elevates angiotensin II and activates immune cells in human testes. These findings also implicate that the human male testes is perfect reservoir for the SARS-CoV-2 virus!

As early as February 2020, Thailand Medical News had published review of research data that the SARS-CoV-2 virus was capable of infecting the male testes ad also making males infertile but our coverage was initially labelled as fake news by a garbage Italian male science writer from Milan and also by garbage and unqualified fact checkers in America employed by Facebook.!-latest-research-published-by-chinese-scientists-say-coronavirus-might-render-certain-male-patients-infertile
Though months after that much has been published about the SARS-CoV-2 virus and the male testes, there remain many unanswered questions.
The study team investigated testicular alterations in deceased COVID-19-patients, the precise location of the virus, its replicative activity, and the molecules involved in the pathogenesis.
Shockingly the study team found that SARS-CoV-2 testicular tropism is higher than previously thought and that reliable viral detection in the testis requires sensitive nanosensoring or RT-qPCR using a specific methodology.
It was found that macrophages and spermatogonial cells are the main SARS-CoV-2 lodging sites and where new virions form inside the Endoplasmic Reticulum Golgi Intermediate Complex.
The study findings discovered infiltrative infected monocytes migrating into the testicular parenchyma.
Furthermore, the SARS-CoV-2 virus maintains its replicative and infective abilities long after the patient infection, suggesting that the testes may serve as a viral sanctuary.
The study found that infected testes show thickening of the tunica propria, germ cell apoptosis, Sertoli cell barrier loss, evident hemorrhage, angiogenesis, Leydig cell inhibition, inflammation, and fibrosis.
The study findings also indicated that high angiotensin II levels and activation of mast cells and macrophages may be critical for testicular pathogenesis.
The study findings suggest that patients who become critically ill exhibit severe damages and may harbor the active virus in testes.
The study findings were published on a preprint server and are currently being peer reviewed.

This is the first study that shows:
-1) the high SARS-CoV- 2 tropism to the testis;
-2) one mode of SARS-CoV-2 entrance in testes;
- 3) SARS-CoV-2 preferred infection and replication in spermatogonia and macrophages;
-4) that the virus remains infective after a long infection period in the testes (viral reservoir);
-5) high levels of angiotensin II and activated mast cells and macrophages are critical players in promoting all testicular alterations;
-6) the more extended severe condition, the lower the number of surviving germ cells;
-7) fluctuation in several essential testicular genes;
-8) that the intratesticular testosterone levels are 30 times reduced in testes of COVID-19 patients;
-9) the prevalent types of collagen present in SARS-CoV-2 mediated testicular fibrosis;
-10) the fluctuation of vasoconstrictive peptides in testes of COVID-19 critically ill patients.
The study team concluded, “Herein, we used different and sensitive methods to detect SARS-CoV-2 proteins, RNA, and virus particles in the testis. We investigated the potential viral, cellular, and molecular mechanisms of infection and damage by SARS-CoV-2 in testes of non-vaccinated and severely ill patients. Our study findings found that a direct influence of SARS-CoV-2 in testicular cells might deregulate ACE2, elevating the levels of angiotensin II, a potent pro-inflammatory and angiogenic peptide. Angiogenic and inflammatory factors might induce the infiltration and activation of mast cells and macrophages. Therefore, the deleterious effects evidenced in the testes of COVID-19 patients, i. e. fibrosis, vascular alteration, inflammation, tunica propria thickening, Sertoli cell barrier loss, germ cell apoptosis, and inhibition of Leydig cells, may be associated with elevated angiotensin II and activation responses of mast cells and macrophages. A protein-protein (or 651 gene-gene) network constructed from the STRING database shows the interaction of genes associated with angiotensin II regulation, activation of mast cells and macrophages, and testis tubular and intertubular compartment alterations.”
Most importantly with even the US. NIH now admitting that viral persistence in so called “recovered COVID-19 individuals’ is common even for months and maybe years after infection, these study findings imply that the male testes might also serve as viral reservoirs during viral persistence.
For more the latest COVID-19 research, keep on logging to Thailand Medical News.

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