For The Latest Medical News, Health News, Research News, COVID-19 News, Pharma News, Glaucoma News, Diabetes News, Herb News, Phytochemical News, Thailand Cannabis News, Cancer News, Doctor News, Thailand Hospital News, Oral Cancer News, Thailand Doctors

BREAKING NEWS
Nikhil Prasad  Fact checked by:Thailand Medical News Team Jun 10, 2025  1 week, 1 day, 16 hours, 1 minute ago

Dangerous Rise in Blood Anandamide Levels Could Be Fueling Lung Damage in COVID-19 Pneumonia

2714 Shares
facebook sharing button Share
twitter sharing button Tweet
linkedin sharing button Share
Dangerous Rise in Blood Anandamide Levels Could Be Fueling Lung Damage in COVID-19 Pneumonia
Nikhil Prasad  Fact checked by:Thailand Medical News Team Jun 10, 2025  1 week, 1 day, 16 hours, 1 minute ago
Thailand Medical News: In a major discovery that could change how scientists and doctors understand lung damage caused by COVID-19, researchers from top American institutions have uncovered a disturbing biological link that may be worsening outcomes in patients suffering from severe COVID-19 pneumonia with respiratory failure.


Dangerous Rise in Blood Anandamide Levels Could Be Fueling Lung Damage in COVID-19 Pneumonia

The new research, conducted by teams from the U.S. National Institutes of Health, University of Chicago, The Permanente Medical Group, Thomas Jefferson University, and the University of Colorado School of Medicine, has found that patients battling acute COVID-19 pneumonia had unusually high levels of a natural compound in the body known as anandamide (AEA). This compound, which is part of the body’s endocannabinoid system and interacts with the cannabinoid receptor 1 (CB1R), was found in far greater amounts in COVID-19 patients than in those with non-COVID-related respiratory failure and even compared to healthy individuals.
 
This Thailand Medical News report highlights the danger posed by this internal chemical. Anandamide, which mimics the effects of cannabis in the brain and body, is known to trigger inflammation and tissue damage when it becomes overactive.
 
The researchers also discovered that another endocannabinoid, 2-arachidonyl glycerol (2AG), was also significantly elevated in the blood of COVID-19 patients. These elevated levels were found to strongly correlate with multiple inflammatory markers in the blood, suggesting a dangerous inflammatory storm could be at play.
 
Using advanced tools like liquid chromatography-mass spectrometry and Luminex assays, scientists were able to pinpoint these elevated endocannabinoid levels from blood samples collected at various stages of illness. The results point to the possibility that this overstimulated endocannabinoid system might be one of the key reasons why some COVID-19 patients develop long-term breathing problems and lung scarring.
 
The study suggests that the CB1 receptor, which is already known to be overexpressed in the lungs of those who died from COVID-19 pneumonia, may play a bigger role in worsening lung inflammation and preventing proper healing. By connecting the dots between high levels of anandamide, CB1 receptor overactivity, and poor lung outcomes, the researchers have opened the door to potentially new treatment strategies that target this pathway.
 
Conclusion
This study offers strong evidence that high circulating levels of anandamide and 2AG during the acute phase of COVID-19 pneumonia are likely contributing to the severe inflammation and lung damage seen in many patients. These findings suggest that blocking the endocannabinoid/CB1R pathway could potentially reduce tissue damage and improve outcomes in those with COVID-19 pneumonia.
 
More importantly, this di scovery helps explain why some individuals develop long-term respiratory issues after the initial infection has passed. Targeting this pathway may provide a much-needed therapeutic option to protect lung function in current and future COVID-19 cases.
 
The study findings were published in the peer reviewed journal: The American Journal of the Medical Sciences.
https://www.amjmedsci.org/article/S0002-9629(25)01070-5/fulltext
 
For the latest COVID-19 News, keep on logging to Thailand Medical News.
 
Read Also:
https://www.thailandmedical.news/news/covid-19-alters-levels-of-circulating-endocannabinoids-in-the-human-host
 
https://www.thailandmedical.news/news/brazilian-study-shows-that-cannabinoids-exhibit-anti-inflammatory-and-protective-effects-on-sars-cov-2-infected-human-heart-cells
 
https://www.thailandmedical.news/news/study-shows-high-fat,-high-sugar-diet-modifies-the-microbiome-and-endocannabinoid-system
 
https://www.thailandmedical.news/articles/coronavirus
 
https://www.thailandmedical.news/pages/thailand_doctors_listings

MOST READ

May 10, 2025  1 month ago
Nikhil Prasad
Apr 29, 2025  2 months ago
Nikhil Prasad
Mar 10, 2025  3 months ago
Nikhil Prasad
Mar 01, 2025  4 months ago
Nikhil Prasad
Feb 17, 2025  4 months ago
Nikhil Prasad

FROM MEDICAL NEWS (WORLD)

LATEST ON THAILAND BIOTECH NEWS