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Genomics and Epigenetics
Featuring all the latest about the newest branch of specialty in the Medical World. From Gene Mapping, new understandings of various Cellular Pathways to breakthroughs in Gene Slicing and Recombinant techniques and even new Gene related treatments.
Source: Thailand Medical News  Feb 01, 2020  2 months ago
Swiss researchers from University Of Geneva (UNIGE) have discovered a new gene that causes blindness and cardiomyopathy. They have also managed to halt the progression of eye disease and treat cardiac disease by administering a food supplement called taurine.   The human genome consists of 20,000 genes, all of which may be capable of triggering disease. It is estimated that there are 7...
Source: Thailand Medical News  Jan 07, 2020  3 months ago
New Study Reveals Most Commercial Labs Conducting Genetic Sequencing Tests Routinely Fail to Analyze Large Segments of DNA, Hence Lacking Accuracy.  A review of clinical tests from three major U.S. laboratories by UT Southwestern Medical Center experts shows whole exome sequencing routinely fails to adequately analyze large segments of DNA, a potentially critical deficiency that can preven...
Source: Thailand Medical News  Dec 19, 2019  4 months ago
Genome and oncology researchers have identified a genetic signature with prognostic value for certain kinds of breast cancer. The discovery also contributes to a better understanding of the molecular mechanisms of pathological angiogenesis, the aberrant proliferation of blood vessels that occurs during cancer and other diseases. The new research combined a study of the genes involved in retinop...
Source: Thailand Medical News  Dec 09, 2019  4 months ago
An individual’s risk of developing cancer is affected by genetic variations in regions of DNA that don’t code for proteins, previously dismissed as ‘junk DNA’, according to new research published in the British Journal of Cancer last week. Professor Dr John Quackenbush, from Harvard T.H. Chan School of Public Health and lead author of the study told Thailand Me...
Source: Thailand Medical News  Nov 30, 2019  4 months ago
Researchers from Massachusetts General Hospital have identified a specific gene, the HDAC9 gene in the calcification of the human aorta, the largest blood vessel in the body. Typically, Cardiovascular Arterial wall calcification is the buildup of calcium in the blood vessel walls, which can often be a predictor of serious cardiovascular events like heart attacks and strokes. Scientists have long ...
Source: Thailand Medical News  Nov 28, 2019  4 months ago
Typically, It is the wish of every molecular geneticist: an easy-to-use program that compares data sets from different cellular conditions, identifies enhancer regions and then assigns them to their target genes. A research team led by Martin Vingron at the Max Planck Institute for Molecular Genetics in Berlin has now developed a program that masters all of this. Dr Martin Vingron, Director and H...
Source: Thailand Medical News  Nov 24, 2019  4 months ago
Researchers from Uppsala University, Sweden in a new study have shown that whole-genome sequencing increases the precision of genetic studies, which in turn can improve our perspectives of how to use biomarkers to discover disease. The results are published in the scientific journal Scientific Reports. Typically, biomarkers, such as specific proteins circulating in our blood stream, are...
Source: Thailand Medical News  Nov 22, 2019  4 months ago
Typically, one of the ways a cancer-causing gene works up enough power to turn a normal cell into a cancer cell is by copying itself over and over, like a Xerox machine. Scientists have long noticed that when cancer-causing genes do that, they also scoop up some extra DNA into their copies. But it has remained unclear whether the additional DNA helps drive cancer or is just along for the ride. ...
Source: Thailand Medical News  Nov 18, 2019  5 months ago
Salk Institute researchers have developed a new gene therapy to help decelerate the aging process. Aging is a leading risk factor for a number of debilitating conditions, including heart disease, cancer and Alzheimer's disease, to name a few. This makes the need for anti-aging therapies all the more urgent.   The research findings, published in the journal Nature Medicine, highligh...
Source: Thailand Medical News  Nov 15, 2019  5 months ago
A new study by the University of Rochester Medical Center New indicates that the benefits of a dietary compound on kidney health may depend on an individual's genetics. The findings may be helpful for tailoring interventions to prevent or treat kidney disease. GSTM1 or Glutathione S-transferase mu-1 is an enzyme that plays a role in ridding the body of toxins and combatting oxidative stress...
Source: Thailand Medical News  Nov 10, 2019  5 months ago
Researchers from Novo Nordisk Foundation Center for Biosustainability, DTU Biosustain have developed a new genome editing tool tool called the CRISPR-BEST. Although existing CRISPR technologies allow for better manipulation of genomes with many positive effects on modern drug development and the discovery of new and better antibiotics, significant problems such as genome instability and toxicity o...
Source: Thailand Medical News  Oct 31, 2019  5 months ago
A group of genomic researchers led by Dr Julián Cerón of the Bellvitge Biomedical Research Institute (IDIBELL), has taken advantage of the similarity between the amino acids and genes of humans and the nematode Caenorhabditis elegans and their expertise in CRISPR gene editing to mimic in C. elegans, the SF3B1 mutations found in human tumors. Although the one-millimeter worm t...
Source: Thailand Medical News  Oct 26, 2019  5 months ago
Cas13, a common gene-editing enzyme could be used to disable RNA viruses such as flu, Zika  or Ebola. CRISPR is usually thought of as a laboratory tool to edit DNA in order to fix genetic defects or enhance certain traits but in reality, the mechanism originally evolved in bacteria as a way to fend off viruses called bacteriophages. Researchers have previously adapted the Cas13 enzyme as a...
Source: Thailand Medical News  Oct 22, 2019  6 months ago
A genomic research team from the Broad Institute of MIT and Harvard have developed a new revolutionary CRISPR genome-editing approach by combining two of the most important proteins in molecular biology : CRISPR-Cas9 and a reverse transcriptase into a single machine. Credit : Susanna M. Hamilton, Broad Institute Communications   The new platform , called “prime editing,&rdqu...
Source: Flatiron Institute's Center for Computational Biology (CCB)  May 29, 2019  10 months ago
Researchers in New York, leveraging on artificial intelligence techniques,  have demonstrated that mutations in so-called 'junk' DNA can cause autism .This study is the first to functionally link such mutations to the neurodevelopmental condition. Led by Olga Troyanskaya , deputy director for genomics at the Flatiron Institute's Center for Computational Biology (CCB) in New Yor...
Source: University of Oxford  May 04, 2019  11 months ago
The discovery of a new way to target and treat the leading genetic contributor to Parkinson's may open the way for a potential new clinical treatment. Researchers from Oxford's Department of Physiology, Anatomy and Genetics (DPAG) have identified how the dysfunction of a key gene, LRRK2, causes the neurons affected in Parkinson's to lose their ability to effectively clear out cell c...
Source: The Translational Genomics Research Institute  Apr 09, 2019  1 year ago
Hepatocellular carcinoma (HCC) is a long medical name for the most common form of liver cancer, a malignancy whose incidence has nearly doubled over the past decade, making it the fastest growing type of cancer in the U.S., and the third-leading cause of cancer-related death worldwide. Researchers at the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, provide the...
Source: Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem (INBEB), Brazil  Feb 07, 2019  1 year ago
Scientists explored mRNA and protein public databases to unravel hidden meanings of the genetic code. Using a metric derived from mRNA codon composition, they found out how gene sequence choice can predict different aspects of protein synthesis, such as protein production efficiency. The study could help the development of new biotechnological applications of genes and proteins. Today, thousand...
Source: Wellcome Trust Sanger Institute  Jan 22, 2019  1 year ago
In the largest genetic study of osteoarthritis to date, scientists have uncovered 52 new genetic changes linked to the disease, which doubles the number of genetic regions associated with the disabling condition. Scientists at the Wellcome Sanger Institute, GSK and their collaborators analysed the genomes of over 77,000 people with osteoarthritis. Their findings, published  in Nature ...
Source: Ontario Institute for Cancer Research  Jan 15, 2019  1 year ago
Researchers at the University of Toronto have discovered mutational signatures of tumor hypoxia (low oxygen) in 19 cancer types. The results could be used to help clinicians identify patients who would benefit from higher treatment doses.   In a landmark pan-cancer study analyzing more than 8,000 tumors across 19 different cancer types, researchers have identified molecular hallmarks of...
Source: University of Michigan  Jan 01, 2019  1 year ago
A change in the genome of Caucasians could explain much-higher rates of the most common type of esophageal cancer in this population, a new study finds. It suggests a possible target for prevention strategies, which preliminary work suggests could involve flavonoids derived from cranberries. "We've known for a long time that esophageal adenocarcinoma primarily affects Caucasians and ver...
Columbia University Irving Medical Center  Dec 27, 2018  1 year ago
A new study has found that genes cause about 1 in 10 cases of chronic kidney disease in adults, and that identifying the responsible genes has a direct impact on treatment for most of these patients.  “Our study shows that genetic testing can be used to personalize the diagnosis and management of kidney disease, and that nephrologists should consider incorporating it into the diagnost...
Source: University Of Manchester  Nov 23, 2018  1 year ago
An international study lead by University of Manchester scientists has discovered the identity of genes that predispose people to chronic kidney disease. The discovery is a major advance in understanding of the significantly under-diagnosed disorder which, if left undetected, can lead to failing kidneys that need dialysis or kidney transplantation.    The discovery of 35 kidney &n...
Source: VIB (The Flanders Institute For Biotechnology)   Nov 19, 2018  1 year ago
Mutations in RAS proteins initiate many of the most aggressive tumors, and the search for pharmacological inhibitors of these proteins has become a priority in the battle against cancer. Michail Steklov, Francesca Baietti, and colleagues from the Anna Sablina lab (VIB-KU Leuven Center for Cancer Biology) identified LZTR1 as an evolutionarily conserved component of the RAS pathway. Multiple ...
Source: Cincinnati Children's Hospital Medical Center  Nov 06, 2018  1 year ago
Study points to possible way to predict increased inflammation risk   With an estimated 40 million people in the world dealing with inflammatory bowel disease (IBD), physicians can have a hard time telling which newly diagnosed patients have a high risk of severe inflammation or what therapies will be most effective. Now researchers report in the journal JCI Insights finding an ep...
Source: Wellcome Trust Sanger Institute  Oct 25, 2018  1 year ago
Researchers at the Wellcome Sanger Institute have created the first comprehensive summary of all genes known to be involved in human cancer, the Cancer Gene Census. Describing all genes strongly implicated in causing cancer, the Census also describes how they function across all forms of this disease. Reported in Nature Reviews Cancer, the resource catalogues over 700 genes, to help scientist...
Source : University of Washington Health Sciences/UW Medicine  Sep 18, 2018  2 years ago
Jay Shendure and Lea Starita, faculty in the Department of Genome Sciences at the University of Washington School of Medicine, are the senior authors. Shendure directs the Brotman Baty Institute for Precision Medicine in Seattle, which helped support the study. Starita co-directs the Brotman Baty Advanced Technology Lab. Shendure is also a Howard Hughes Medical Institute investigator. Greg Findla...
Source: University of Copenhagen The Faculty of Health and Medical Sciences  Aug 28, 2018  2 years ago
With a new groundbreaking technique, researchers from University of Copenhagen have managed to identify a protein that is responsible for cellular memory being transmitted when cells divide. The finding is crucial for understanding development from one cell to a whole body. The cells in our body divide constantly throughout life. But how do cells remember whether to develop into a skin, liver or ...
Source: Kobe University  Aug 08, 2018  2 years ago
By destroying the regulatory genes of the AIDS virus HIV-1 using the genome editing system CRISPR/Cas9, a Japanese research group has succeeded in blocking the production of HIV-1 by infected cells.   Human immunodeficiency virus-1 (HIV-1) infection is a chronic disease affecting more than 35 million people worldwide. The infection can be controlled by antiretroviral therapy (ART), but the...
Source: Uppsala Universitet  Jul 23, 2018  2 years ago
Epigenetic changes are chemical modifications that turn our genes off or on. In a new study, researchers show that tea consumption in women leads to epigenetic changes in genes that are known to interact with cancer and estrogen metabolism.   Epigenetic changes are chemical modifications that turn our genes off or on. In a new study from Uppsala University, researchers show that tea consum...
Source: Mayo Clinic  Jul 21, 2018  2 years ago
Six genes associated with pancreatic cancer have been identified by a research team at Mayo Clinic. The team finds that these genes can be inherited but are also present in patients with no family history of pancreatic cancer.   The team recommends genetic testing for all pancreatic cancer patients as the new standard of care.   ‘Six genes contain mutations that can be inherited ...
Source: Wellcome Trusts Sanger Institute  Jul 11, 2018  2 years ago
Genetic variants can increasingly be used to connect patients to treatments as well as uncover new therapeutic targets.   Jeffrey Barrett, formerly of the Wellcome Trust Sanger Institute, described how prioritizing genome-wide association study results has uncovered drugs that could be used to treat inflammatory bowel disease.   Functional Studies on the IBD Susceptibility Gene IL23R I...
Source: Johns Hopkins Medicine  Jul 10, 2018  2 years ago
In a review article published in the New England Journal of Medicine, scientist Andrew Feinberg, M.D., calls for more integration between two fields of DNA-based research: genetics and epigenetics.   Most people are familiar with genetics, a field of research that focuses on the precise sequence of chemicals that form the ladder-like structure of DNA. However, epigenetics is not as wel...

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