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COVID-19 News - SARS-CoV-2 -Heart Failure  Dec 30, 2022  8 months, 3 weeks, 5 days, 5 hours, 4 minutes ago

COVID-19 News: Italian Study Shockingly Discovers That All Exposed To The SARS-CoV-2 Virus Have An Additional 90 Percent Risk Of Developing Heart Failure!

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COVID-19 News: Italian Study Shockingly Discovers That All Exposed To The SARS-CoV-2 Virus Have An Additional 90 Percent Risk Of Developing Heart Failure!
COVID-19 News - SARS-CoV-2 -Heart Failure  Dec 30, 2022  8 months, 3 weeks, 5 days, 5 hours, 4 minutes ago
COVID-19 News: More great news for 2023 especially for the COVID-19 minimizers and also for all the morons who keep on with the narratives “that we have to live with COVID-19 or that the new variants are now mild and we are just in a endemic phase and need not worry much!”

Italian researchers and cardiologists from West Vicenza Hospitals, Madre Teresa Hospital and Maria Della Misericordia Hospital in a new detailed meta-analysis study involving data from 1,628,424 patients who had contracted COVID-19 have alarmingly found that all individuals who have been exposure to the SARS-CoV-2 virus have an additional 90 percent risk of developing heart failures!
Their study findings corelates with growing incidences of heart failures (HF) globally especially in the last two years of the COVID-19 pandemic and also if one was to analyze excess deaths rates as a result of heart failures in specific countries, the data would be most interesting and reflect on what health authorities are concealing!,802-excess-deaths-in-2020-related-to-only-cardiovascular-issues-found-in-the-united-states-during-the-first-year-of-the-covid-pan
The study findings also raises questions about whether we will see an even higher incidence of heart failures (HF) and also fatal outcomes as the world is now in a new phase of the COVID-19 pandemic in the sense we are no longer facing periodic waves driven by one or two specific new variants of concern or VOCs but rather we are going through a continuous onslaught by a cluster of so many different SARS-CoV-2 variants, sub-lineages and new recombinant variants that are continuously being replaced by many newer emerging variants and sub-lineages!
It has already been widely accepted that individuals who have recovered from COVID-19 have an increased incidence of cardiovascular disease and heart structural changes.
Thailand Medical News have already published various COVID-19 News articles covering such research findings.,-some-with-fatal-outcomes
The Italian study team however aimed to assess the risk of incident heart failure (HF) after COVID-19 infection.
Study data were obtained searching MEDLINE and Scopus for all studies published at any time up to September 1, 2022 reporting the risk of incident HF in COVID-19 recovered patients.
The subsequent cumulative post-COVID-19 incidence and risk of incident HF were pooled using a random effects model and presented with the corresponding 95% confidence interval (CI). Statistical heterogeneity was measured using the Higgins I2 statistic.
In all, a total 21,463,173 patients (mean age 54.5 years, 58.7% males) were analyzed. Among them, 1,628,424 had confirmed COVID-19 infection while the remaining 19,834,749 represented the controls. The mean length of follow-up was 9.2 months.
Interestingly, a random effect model revealed a pooled incidence of post COVID-19 HF in 1.1% of cases (95% CI: 0.7–1.6, I2: 99.8%).
Importantly, recovered COVID-19 patients showed an increased risk of incident HF (HR: 1.90, 95% CI: 1.54–3.24, p < 0.0001, I2 = 96.5%) in the same follow-up period.
Meta-regression showed a direct relationship for the risk of incident HF using age (p = 0.001) and hypertension (HT) (p = 0.02) as moderators, while an inverse association was observed when the follow-up length was adopted as moderating variable (p = 0.01).
The study findings showed that COVID-19 survivors had an additional 90% risk of developing HF after COVID-19 infection in the long-term period. This risk was directly related with age and previous history of HT especially in the early post-acute phase of the infection.
The study findings were published in the peer revied journal: Heart Failure Reviews (Springer)
The study findings based on a very large population of more than 20 million individuals, demonstrated that many Post COVID individuals had an additional 90% risk of developing heart failure (HF) within 9 months from the acute infection.
The findings showed that this risk was directly influenced by age and previous history of HT and resulted higher in the early post-acute phase of the infection, as demonstrated by the meta-regression.
However, the study findings also showed even with the absence of any correlation with other cardiovascular risk factors or comorbidities, the risk of incident of heart failure (HF) still manifest even in subjects at relatively low cardiovascular risk!
The study team said that the high heterogeneity observed may be partly explained by the differences in baseline characteristics of the population enrolled, immunization against COVID-19 infection, pre-existing cardiovascular risk factors, or previous HF history. Although sensitivity analysis confirmed the robustness of the study findings, the estimates should be carefully considered.
The meta-analysis study represents the first attempt to comprehensively assess the risk of incident of heart failure or HF in the post-acute phase of COVID-19 subjects.
Interestingly, the study team observed that the HF risk was comparable between men and women, although this result had to be cautiously considered. Indeed, the comparison of rates between gender is highly dependent on the age range of the population under study. Furthermore, when the death rate is high from causes other than the disease of interest, the incidence rates of the disease are generally overestimated in traditional Kaplan-Meier survival analysis due to competing risks. Nevertheless, sensitivity analysis confirmed the robustness of the study findings.
However, the exact pathophysiological mechanism underling the higher risk of heart failure or HF in Post COVID individuals has not yet been completely established.
To a certain extent, the direct viral invasion of cardiomyocytes and subsequent cell death or endothelial cell infection and subsequent dysfunction or the complement-mediated coagulopathy and microangiopathy may represent some of potential triggers.
The study team said, “Indeed, we cannot evaluate if COVID-19 infection represented just a trigger or the underlying cause of HF during the follow-up period.”
The study findings are in accordance with the results provided an earlier study by which observed an increased risk of heart failure or HF in COVID-19 survivors within 89 days, but their results were presented as risk ratio and therefore they were not included in our meta-analysis. Indeed, it would be incorrect to pool risk ratio and hazard ratio together since they evaluate different outcomes from different study designs.
The study findings have several implications for daily clinical practice and future research. The HF risk is not limited just to the acute phase of the infection but extends in the medium/long-term period, indicating the need to prevent the infection and to consider post COVID-19 patients at future risk of HF. As consequence, the epidemiology of the disease may change in term of rates of relative hospitalizations and associated outcomes as well as in the related costs for the public health care systems.
Physicians and doctor are already wondering whether the COVID-19 pandemic will be followed by a cardiovascular after shock.
The study findings, for the first time, provide preliminary comprehensive evidence regarding the higher risk of heart failure (HF) in Post COVID individuals which emphasizes the need of specific clinical follow-up for these subjects to prevent long-term cardiovascular consequences.
For the latest COVID-19 News, keep on logging to Thailand Medical News.
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