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COVID-19 News - Antibodies-Safe?  Jan 16, 2023  1 year, 2 months, 2 days, 15 hours, 9 minutes ago

COVID-19 News: Are All These Antibodies Elicited By Various Jabs And Boosters And Frequent SARS-CoV-2 Infections Really Safe For The Human Body?

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COVID-19 News: Are All These Antibodies Elicited By Various Jabs And Boosters And Frequent SARS-CoV-2 Infections Really Safe For The Human Body?
COVID-19 News - Antibodies-Safe?  Jan 16, 2023  1 year, 2 months, 2 days, 15 hours, 9 minutes ago
COVID-19 News: Pardon my ignorance and stupidity but was the human body developed to be able to withstand the frequent and sudden boost of antibodies by frequent COVID-19 jabs and boosters for a particular antigen like 2 to 4 times a year or even to deal with the antibodies elicited by constant infections or reinfections now that we have having continuous onslaught by various emerging SARS-CoV-2 variants, sub-lineages and also recombinant variants that are constantly being replaced by newer more immune evasive ones? It is now a common occurrence for people to get infected with COVID-19 four to five times a year and soon maybe even more!


 
Our knowledge about antibodies are also limited to a certain degree let alone about the detailed workings of the immune system….while the field of medicine has progressed in the last few decades, there is still so much we do not yet know about the immune system and also about antibodies and yet for the COVID-19 pandemic, scientist and researchers along with health authorities picked the lazy route of only focusing on antibody based prophylactics and therapeutics even though previous experience with the SARS-CoV virus of 2003 showed that such an approach was not safe nor advisable.
https://pubmed.ncbi.nlm.nih.gov/22536382/
 
https://www.sciencedirect.com/topics/medicine-and-dentistry/severe-acute-respiratory-syndrome-vaccine
 
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851497/
 
The COVID-19 pandemic started with experts first using convalescent plasma, the monoclonal drugs and combo monoclonal drugs and off course the COVID-19 jabs and then boosters.
 
Three years later, the convalescent plasma not only does not work but also brings about complications, all of the monoclonal therapeutics no longer work against the new variants and sub-lineages, the COVID-19 vaccine narratives changed from them being able to protect you from getting infected and also stopping transmissions to that it prevents you from developing disease severity and decreases mortality risk to now where emerging data shows that for older folks after the age of 65, even four shots are no longer helping them! There is more but I am not here to go down that route! I have already covered these in many of our past COVID-19 News coverages. (Please use the search function of TMN site)
 
Also we are seeing that  all these elicited antibodies lead to the development of the emergence of various more immune evasive variants and sub-lineages.
 
Rather I am curious….was the human body really designed to handle such sudden and frequent  ‘burst’ of antibodies of a particular pathogen and what do we really know about the other effects of the antibodies on the various cellular processes in the body, on cells and tissue. Are antibodies really safe?
 
Simply researching online, I came across the fact that antibodies can also cause disease and health issu es.
 
While antibodies are defensive molecules, part of the body’s adaptive immune response to pathogens, they can also harm the same host they are produced by to defend it against foreign bodies and organisms.
 
To date, several types of antibody-mediated diseases are known. Some are thought to be adverse effects of vaccination, which is logical since vaccines, by definition, cause their effects via stimulation of the immune system. For instance, individuals may have idiosyncratic reactions to vaccines.
 
Vaccines can sometimes cause disease enhancement when the virus circulates as multiple serotypes or as neutralizing titers wane. It is important to note that antibody dependent-enhancement (ADE) has been proven, and its clinical relevance is also critical in vaccine studies.
 
It was also found that antibodies may also develop against self-antigens in the body due to their linkage with or modification by another non-self antigen or their close similarity with a foreign antigen. These autoantibodies act in various ways: mimicking receptor stimulation, blocking neural transmission, triggering abnormal signal pathways leading to widespread coagulation within the microvasculature, breakdown of immune cells, activation of neutrophils, and hyper-inflammatory responses.
 
Pathological immunologic reactions to antigens that are not always noxious in themselves are classified as type I through type IV: type I, immediate hypersensitivity, including anaphylaxis; type II, tissue antigen-antibody reactions; type III, Arthus-type reaction, due to immune complex (antigen-antibody complex) deposition in tissues, followed by complement and leukocytes; and type IV, delayed-type hypersensitivity, mediated by T lymphocytes and macrophages.
 
Allergies are also inflammatory disorders with an immunological origin but do not involve tissue destruction; rather, the body overreacts to harmless substances. Conversely, with autoimmune disorders, tissues and organs are destroyed by the immune cells that react to them as if to a pathogen.
 
A-In Type I Pathological Immunologic Reactions, anaphylaxis is an extreme, sudden, potentially fatal systemic immunologic reaction mediated by the bioactive molecules released from mast cells and basophils. Such mediators include histamine, platelet-activating factor, and arachidonic acid metabolites. The reaction is triggered via antigen binding to the immunoglobulin type E (IgE) antibodies on the mast cells and basophils, for the most part, though other Ig classes can also participate on occasion. In the latter case, antigen-antibody complexes that activate the complement system are formed, with complement components triggering mediator release from basophils and mast cells, most typically after intravenous entry of an antigen.
 
It was found that the chemical mediators enter the circulation and are responsible for the systemic nature of the reaction. However, the rate of formation of IgE in response to the antigen may vary, as may the entry of the antigen into the circulation. As a result, the symptoms of anaphylaxis may be delayed for up to four hours from the vaccination or other exposure, which is typically following prior exposure to the same or another very similar antigen.
Physiologically, anaphylaxis is triggered by fluid leakage from blood vessels, vasodilatation, and smooth muscle contraction in certain locations, causing edema, laryngospasm, bronchospasm, hypotension, and cardiovascular collapse. Either the first or the second set of symptoms is sufficient to cause death if not promptly and adequately treated.
 
Furthermore, subacute anaphylaxis also occurs, causing urticaria, facial swelling, bronchoconstriction, and itching, but without shock and collapse.
 
B-In Type II Pathological Immunologic Reactions, the tissue antigen is either cross-reactive with an antibody formed in response to a food- or pathogen-borne antigen. Alternatively, the antigen has been altered, making it reactive to the antibody. These triggers complement activation, which causes inflammation in the tissue of deposition. The result is tissue damage.
 
C-In Type III Pathological Immunologic Reactions, immune complex deposition in the presence of excess antigen occurs in blood vessel walls, causing organ damage over up to 16 hours if antibody levels are raised, or over several days as in serum sickness, in proportion to rising antibody levels with the persistence of the inciting antigen. The inflammatory reaction in the blood vessel wall is mediated by neutrophils and complement and may trigger massive tissue damage.
 
Such type of reaction is found locally after repeated immunization when circulating IgG levels are already high. The site is painful and indurated, but the process resolves spontaneously over a few days. By allowing antibody levels to wane, as by increasing the spacing between doses, this reaction can be reduced.
 
C-In Type IV Pathological Immunologic Reactions, cell-mediation leads to lymphokine release, infiltration by macrophages with a positive loop feedback resulting in increased immune system stimulation. The neurologic adverse effects of vaccination, in the current scenario, may be due to type IV reactions.
 
ADE
COVID-19 shots and boosters given in tandem can cause a reduction in immune activation, theoretically, because of the potential immunosuppressive effect of certain vaccine constituents. While most studies to date have not shown evidence of this effect, in the form of increased infections after immunization with the diphtheria-tetanus toxoid-pertussis (DTP) or measles vaccines, for instance, uncertainty lingers. Further research will be required to rule out this possibility after vaccination.
 
However, with the COVID-19) pandemic, the vaccine has been suspected to be capable of causing ADE of disease. The SARS-CoV-2 virus certainly does take advantage of its binding to antibodies on the surface of phagocytic cells such as dendritic cells and macrophages by using the antibody Fc portion for cell attachment to jumpstart its infection of such cells.
 
Hence, It is thought that high levels of antibodies to the virus during early infection may cause ADE following vaccination.
 
Young children and Infants with SARS-CoV-2 infection may also develop multisystem inflammatory syndrome in children (MIS-C) for the same reason, due to maternal mast-cell-bound antibodies to the virus.
 
Furthermore, the administration of antibodies, either therapeutic monoclonal antibodies or convalescent plasma, or B cell vaccines, could carry the risk of worsening disease severity in case breakthrough infection occurs. In contrast, B cell vaccines that disrupt virus spike-mediated host cell fusion are likely to present little, if any, risk of ADE because they act via steric hindrance. Conversely, antibodies that target other parts of the spike may have neutralizing activity and yet allow infection of phagocytic cells.
 
Mechanism Of ADE
Typically, phagocytes express specific antibodies to help eliminate the virus via antibody-mediated recognition and phagocytosis. As observed with earlier coronaviruses, the virus may infect monocyte-derived macrophages (MDMs), monocyte-derived dendric cells (MoDCs), and T cells. When the virus binds these phagocytes, they release chemokines that recruit additional but immature dendritic and macrophage cells.
 
These are however vulnerable to infection, causing a potential amplifying cascade of phagocyte infection and macrophage accumulation. This causes a cytokine storm as high concentrations of chemokines are released, resulting in severe or critical disease. The excessive cytokine levels also lead to a dysregulation of adaptive immunity, shifting the response towards a hyper-inflammatory profile.
 
It was found that peripheral T cells are markedly reduced in these patients, with both CD4 and CD8 cells involved. T cell apoptosis may occur. The impaired immune response and the possible extensive spread of the infected phagocytes in the body, with high viremic levels, can cause more severe disease.
 
ADE is the result of binding non-neutralizing antibodies that recognize but do not prevent infection with a pathogen, instead of providing a landing place for it to enter and infect the host cell. Thus, the antibodies generated by the vaccine promote viral spread to a larger number of cells than it could have done on its own, leading to the appearance of more severe illness in the unvaccinated person than in the vaccinated.
 
Many viruses with a risk of vaccine- or infection-associated ADE fuse with the host cell membrane during the process of infection. In fact, the earlier SARS-CoV vaccine was hindered by the demonstration of immunologic lung disease in breakthrough infection, with the clinical phenotype taking a turn for the worse as antibody class switching occurs and immunoglobulin G (IgG) appears in the blood.
 
However, with the COVID-19 vaccines, ADE has not been demonstrated, and most people infected after vaccination show mild or asymptomatic infection. Certain vaccine candidates against the respiratory syncytial virus (RSV) and measles vaccines showed features of severe disease in infected children with a prior vaccination history and were never approved or were withdrawn immediately afterward.
 
Autoimmunity
Autoantibodies are implicated in a host of autoimmune diseases. Autoantibodies are antibodies that are reactive to self-molecules in healthy people. They belong mostly to the IgM class and provide primary defense against infection while maintaining homeostasis.
 
Interestingly, pathologic IgG autoantibodies have a high affinity for self-antigens and show evidence of somatic hypermutation, indicating that their role in cell clearance, cell effector functions, and antigen-receptor communication is abnormal. In some cases, the presence of specific autoantibodies before clinical symptoms make their appearance serves as a biomarker for prediction and early preventive measures.
 
Systemic and organ-specific autoimmune diseases are known, with systemic lupus erythematosus and myasthenia gravis being respective examples. In the first case, autoantibodies bind to the target organs and cause damage, while in the latter, autoantibodies bind to multiple molecular and antigenic targets to form toxic immune complexes. These activate not only complement but also Toll-like receptors within the cell. The latter process causes a type I interferon response or cell activation and cytokine production, depending on the type of dendritic cell involved. The production of immune complexes may thus set a positive feedback loop into motion to result in hyper-inflammation.
 
All the above are just a some of these things were know about the possible adverse effects of antibodies but there are lots more we still we do not. For instance, will the frequent shots and boosters harm the immune system and will the sudden ‘burst’ of antibodies each time have effects on the cellular processes, cells and also tissues. Same when frequent infections and also reinfections occur.
 
We already know that the virus is causing various immune dysfunctions directly through a variety of ways and is damaging the immune system. But the key question is ….are all these sudden and frequent ‘burst’ of antibodies healthy and safe for the human body. Sounds like a stupid and easy question for many prominent immunologists on twitter. Would appreciate your ‘expertise’ before I release some interesting new studies!
 
Even more interesting, we have even yet to touch on viral persistence and its effects on antibody production and the immune system after it has managed to evade immune responses! We have yet to even to analyze the effects of decayed or damaged antibodies on the rest of the host cellular processes!
https://journals.asm.org/doi/10.1128/JVI.03177-15
 
https://www.sciencedirect.com/science/article/pii/S0042682205005921
 
https://www.science.org/doi/10.1126/sciimmunol.abe0367
 
https://reports.mountsinai.org/article/gi2022-_6_evolution-of-antibody-immunity-in-the-bowel#content
 
https://www.sciencedirect.com/science/article/pii/S0042682205005921
 
For the latest COVID-19 News, keep on logging to Thailand Medical News.
 
Article References:
https://www.frontiersin.org/articles/10.3389/fimmu.2021.640093/full
 
https://www.ncbi.nlm.nih.gov/books/NBK236294/
 
https://www.frontiersin.org/articles/10.3389/fimmu.2017.00603/full
 
https://www.nature.com/articles/ncprheum0895
 
https://www.chop.edu/centers-programs/vaccine-education-center/vaccine-safety/antibody-dependent-enhancement-and-vaccines
 
https://www.nature.com/articles/d41586-021-00149-1
 
https://www.nature.com/articles/s41586-020-2538-8
 
 

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