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Source: COVID-19-Diagnostics  Nov 28, 2021  2 years, 4 months, 2 weeks, 6 days, 3 hours, 28 minutes ago

University Of Montreal Study Shows That The Amount Of Viral RNA In The Blood Is A Reliable Indicator Of COVID-19 Mortality Risk

University Of Montreal Study Shows That The Amount Of Viral RNA In The Blood Is A Reliable Indicator Of COVID-19 Mortality Risk
Source: COVID-19-Diagnostics  Nov 28, 2021  2 years, 4 months, 2 weeks, 6 days, 3 hours, 28 minutes ago
COVID-19-Diagnostics: A new study by researchers from the University of Montreal-Canada has shown that measuring the amount of viral RNA in the blood is a reliable indicator of COVID-19 mortality risk.

 
To date, despite advances in COVID-19 management, identifying patients evolving toward death remains challenging.
 
In order the to identify early predictors of mortality within 60 days of symptom onset (DSO), the study team performed immunovirological assessments on plasma from 279 individuals.
 
On samples collected at DSO11 in a discovery cohort, high severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral RNA (vRNA), low receptor binding domain–specific immunoglobulin G and antibody-dependent cellular cytotoxicity, and elevated cytokines and tissue injury markers were strongly associated with mortality, including in patients on mechanical ventilation.
 
A three-variable model of vRNA, with predefined adjustment by age and sex, robustly identified patients with fatal outcome (adjusted hazard ratio for log-transformed vRNA = 3.5). This model remained robust in independent validation and confirmation cohorts. Since plasma vRNA’s predictive accuracy was maintained at earlier time points, its quantitation can help doctors and researchers understand disease heterogeneity and identify patients who may benefit from new therapies.
 
The study findings were published in the peer reviewed journal: Science Advances. https://www.science.org/doi/10.1126/sciadv.abj5629
 
Medical professor Dr Daniel Kaufmann from the Université de Montréal told Thailand Medical News, “The amount of a SARS-CoV-2 genetic material-;viral RNA-;in the blood is a reliable indicator in detecting which patients will die of the disease.”
 
Dr Kaufmann and his team conducted the research work at the CRCHUM, the research arm of Univerity of Montreal's teaching hospital, the Centre hospitalier de l'Université de Montréal.
Dr Kaufmann added, "In our study, we were able to determine which biomarkers are predictors of mortality in the 60 days following the onset of symptoms."
 
CRCHUM researchers Dr Nicolas Chomont and Dr Andrés Finzi who assisted on the study added, "Thanks to our data, we have successfully developed and validated a statistical model based on one blood biomarker-viral RNA.”
 
To date physicians have found it hard to identify patients most at risk of dying of the disease and so be able to offer them new treatments.
 
The COVID-19-Diagnostics study found that although several biomarkers have been identified