Thailand Medical Researchers Find That Lotus Seeds Lower Blood Pressure Naturally
Nikhil Prasad Fact checked by:Thailand Medical News Team Oct 10, 2025 8 hours, 33 minutes ago
Thailand Medical: Lotus Seeds Show Potential as a Natural Hypertension Remedy
A groundbreaking discovery by Thailand Medical Researchers has revealed that the seeds of the sacred lotus plant, Nelumbo nucifera, could help lower blood pressure naturally. Scientists from Naresuan University, Chiang Mai University, and the Thailand Institute of Scientific and Technological Research collaborated on a detailed study that identified how lotus seed extract promotes blood vessel relaxation and enhances nitric oxide production, a key mechanism for maintaining healthy circulation. According to this
Thailand Medical News report, the findings suggest that the extract could become a safe natural option for managing hypertension and supporting cardiovascular health.
Thailand Medical Researchers Find That Lotus Seeds Lower Blood Pressure Naturally
Breakthrough Discovery from Thai Scientists
Using advanced analytical methods, the researchers identified 114 compounds within the lotus seed extract, including antioxidants, flavonoids, and powerful alkaloids such as nelumborine, nelumboferine, neferine, and isoliensinine. Laboratory tests showed that the extract significantly relaxed the arteries in rats when the inner layer of blood vessels was intact. This effect was largely due to enhanced nitric oxide signaling—a molecule known for helping blood vessels widen and improve blood flow. When the endothelium was removed or nitric oxide synthesis was blocked, the relaxation effect was drastically reduced, confirming that lotus seed extract acts through this natural vascular pathway.
Nitric Oxide and Calcium Channel Inhibition
Further experiments on human endothelial cells demonstrated that lotus seed extract boosted nitric oxide production without causing any cellular damage. This indicates that the extract is both potent and safe. The team also discovered that the extract prevents calcium from entering blood vessel walls, effectively blocking one of the main causes of vessel tightening and high blood pressure. When tested on rats, intravenous doses of the extract caused a measurable drop in systolic and diastolic blood pressure—showing a clear and dose-dependent hypotensive effect.
Computer Modeling Reveals Deep Biological Insights
To understand how the extract works at a molecular level, researchers from the University of Tsukuba in Japan conducted computer simulations showing that the active alkaloids from lotus seeds bind tightly to the endothelial nitric oxide synthase (eNOS) enzyme. This interaction, especially at the tetrahydrobiopterin (BH4) binding site, helps stabilize the enzyme and increase nitric oxide production, confirming a scientific basis for the observed blood pressure-lowering effects.
A Promising Future for Natural Medicine
This discovery offers new hope for people suffering from hypertension by introducing a plant-based solution that works in harmony with the body’s natural processes. The lotus seed extract not only helps widen blood vessels but may also improve overall va
scular health without the side effects often seen in synthetic medications. It demonstrates how traditional Thai herbal knowledge continues to inspire modern medical innovation.
The study findings were published in the peer reviewed journal: Pharmaceuticals
https://www.mdpi.com/1424-8247/18/10/1500
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