COVID-19 Drugs: Researchers from Yale University School of Medicine in a new study exploring the inhibitory effects of the drug merofloxacin on frameshifting during SARS-CoV-2 replication have reported positive results in vitro studies. The study findings are an important proof-of-concept that supports the potential for targeting −1 PRF (programmed −1 ribosomal frameshifting) as a...
Aspirin-COVID-19: A new study led by researchers from University of Maryland School of Medicine (UMSOM) shows that hospitalized COVID-19 patients who were taking a daily low-dose aspirin to protect against cardiovascular disease had a significantly lower risk of complications and death compared to those who were not taking aspirin.
Importantly, aspirin takers were less likely to be placed...
Source: COVID-19 -Dexamethasone Oct 24, 2020 4 days ago
COVID-19 -Dexamethasone: A new study led by researchers from University of Virginia-U.S. along with scientist from Polish Academy of Sciences-Poland, Poznan University of Technology-Poland, Medical University of Bialystok-Poland and University of South Carolina-U.S. has discovered a about how the human body transports dexamethasone, a drug that can increase the survival chances of patients wi...
America Latest: America is facing a major health crisis with the Trump Administration in power and the degree of incompetency, greed and corruption in play. Already America has a total of more than 8.4 million confirmed COVID-19 cases with realistic figures expected to be much higher due to under-reporting in Republican controlled states and lack of testing among asymptomatic cases and as of today...
Drugs-COVID-19: Fortunately another COVID-19 drug scam is being prevented after the remdesivir saga thanks to honest and credible researchers that cannot be manipulated by money. The US FDA under the Trump administration and Trump’s family and cronies has done even damage with hydrochloroquine and remdesivir issues with many American lives lost and hopefully after Trump loses this elections,...
COVID-19 Drugs: Ensifentrine a drug originally developed by UK based pharmaceutical cum biotech company Verona Pharma to treat chronic obstructive pulmonary disease or COPD could be a new treatment option for hospitalized COVID-19 patients. According to research this dual bronchodilator and anti-inflammatory drug be safe and effective in COVID-19 patients experiencing the debilitating effects of s...
Remdesivir: Interim results from the Solidarity Therapeutics Trial, coordinated by the World Health Organization, indicate that remdesivir, hydroxychloroquine, lopinavir/ritonavir and interferon regimens appeared to have little or no effect on 28-day mortality or the in-hospital course of COVID-19 among hospitalized patients.
The study results of the trial are under review for publi...
Source: COVID-19 Intranasal Drugs Oct 15, 2020 13 days ago
COVID-19 Intranasal Drugs: North Carolina based clinical-stage biotechnology company Novan, Inc. that specializes in various nitric oxide based therapeutics has announced that its vitro studies involving its NITRICIL™ platform technology that uses berdazimer sodium has demonstrated antiviral effects against the SARS-CoV-2 coronavirus tha causes the COVID-19 disease.
Berdaz...
Source: COVID-19 Therapeutics Oct 13, 2020 15 days ago
COVID-19 Therapeutics: According to new research carried out at the University of St Andrews-Scotland, a new inhalation treatment protocol and drug involving synthetic interferons to prevent the spread of COVID-19 is potentially far more effective than currently existing versions of interferons or inhalation protocols.
The Scottish biotech company, ILC Therapeutics based in Newhouse...
COVID-19 Drugs: A new vivo study involving animal models by researchers from Hong Kong University show that the cheap stomach ulcer drug ranitidine bismuth citrate (Tritec) is able to inhibit the SARS-CoV-2 coronavirus.
The study team on Monday announced that the anti-microbial drug used to treat stomach ulcers and bacterial infections has shown promise in combatting the coronavirus...
COVID-19 Help: While tens of thousands are getting infected daily and thousands are dying each day, millions elsewhere are worried and are trying to find ways to help themselves and their loved ones and the only thing that stupid health authorities and incompetent corrupted governments around the world are doing are giving false hopes by an anticipated COVID-19 vaccine that many think will solve t...
COVID-19 Scams? As anticipated, Eli Lily and Regeneron have applied for emergency approval for their laboratory -produced antibodies against COVID-19 and Donald Trump aka ‘Loony Dump Trump’ has signaled his strong presidential backing based on the fact he was treated with them. (There no proof if he was really infected and the whole thing could have been elaborately staged or is ...
Source: COVID-19 Treatments Oct 06, 2020 22 days ago
COVID-19 Treatments: Australian researchers from The University of Newcastle, Hunter Medical Research Institute-New South Wales, University of Technology Sydney and Chinese scientists from Jilin University-Changchun have in a new study confirmed that the SARS-CoV-2 spike glycoprotein subunit 1 can induce a pro-inflammatory signaling pathway (leading to cytokines deployment and epithelial...
Source: COVID-19 Breakthrough Oct 06, 2020 22 days ago
COVID-19 Breakthrough: Canadian researchers have made a major breakthrough during a study on UPR or unfolded protein response during coronaviruses viral replication leading them to a discovery of thiopurines to stop the viral replication of human coronaviruses including SARS-CoV-2. This breakthrough with further research could lead to a new and effective broad-spectrum therapeutic antiviral that c...
COVID-19 Drugs: An urgent immediate safety review of the drug Remdesivir has been called by the European Medicines Agency after numerous COVID-19 patients taking the drug have developed serious kidney problems.
The EU regulator issued a statement a few hours ago saying that it seemed that remdesivir was causing the "acute kidney injury," and that the issue "warrants further...
Drugs-COVID-19: Anti-tumour necrosis factor (anti-TNF) drugs or TNF inhibitors are now being explored by numerous researchers to treat COVID-19 after recent studies of patients with COVID-19 have shown that patients already taking anti-TNF drugs for inflammatory bowel disease and inflammatory arthritis are less likely to be admitted to hospital. The same was not observed for patients taking other ...
Source: COVID-19 Intranasal Drugs Sep 30, 2020 28 days ago
COVID-19 Intranasal Drugs: Researchers from the National Infection Service-UK, Ena Respiratory, Melbourne-Australia, The University of Melbourne-Australia, University of Newcastle-Australia and Oxford University-UK are exploring the usage of TLR2/6 Agonist INNA-051 as an intranasal prophylaxis against COVID-19.
To date their vivo studies involving animal models showed that the TLR2 agonis...
Source: COVID-19 Research Sep 30, 2020 28 days ago
COVID-19 Research: A study led by researchers from the University of Cincinnati along with scientists from University of Duisburg-Germany, the German Primate Center and Saarland University-Germany have discovered that sphingosine, a naturally occurring lipid in the human body could be used as a potential treatment for COVID-19 as prevents binding of SARS-CoV-2 spike to its cellular receptor ...
Source: COVID-19-Povidone-Iodine Sep 27, 2020 1 month ago
COVID-19- Povidone-Iodine: A study led by researchers from the University of Connecticut School of Medicine-Farmington along with experts from The Institute for Antiviral Research at Utah State University, Veloce BioPharma-Florida, ProHealth-Farmington and Ocean Ophthalmology-Florida has demonstrated that an antiseptic nasal spray containing povidone-iodine may help curb transmission of the SARS-C...
Source: Metformin-COVID-19 Sep 26, 2020 1 month ago
Metformin-COVID-19: A few past research studies the last few months has shown the possibility of using metformin, the common cheap and easily available diabetes drug being used for COVID-19 treatments as it was found to reduce severity and mortality rates in COVID-19 patients.
In one study, the researchers found that among more than 600 patients with diabetes and COVID-19, use of metformin ...
Source: COVID-19 Treatments Sep 24, 2020 1 month ago
COVID-19 Treatments: Two new studies by researchers from the University of California-San Diego show that statin usage is linked to a lower risk of developing COVID-19 severity and that removing cholesterol from cell membranes prevents the virus from getting into these cells.
Furthermore there is some biologic plausibility for a protective role of statins in COVID-19 through known anti-in...
Source: COVID-19 Treatments Sep 22, 2020 1 month ago
COVID-19 Treatments: Medical researchers and physicians are now trying interrupt the SARS-CoV-2 coronavirus before it gets into the lungs and the rest of the body and starts ravaging the body, targeting not only the lungs, heart and blood vessels but even the cerebrospinal fluids, the brain, the kidneys, the gastroenterological tract , the male testis to even the immune system itself.
The...
Source: COVID-19 Scams-Russia Sep 22, 2020 1 month ago
COVID-19 Scams: It was announced that Russia has approved R-Pharm's Coronavir treatment for outpatients with mild to moderate COVID-19 infections and the antiviral drug could be rolled out to pharmacies throughout the country as soon as next week, the company said on Friday.
The drug’s approval as a prescription drug follows the green light for another Russian COVID-19 drug, Avi...
COVID-19 Scams: Of all the stupidity and craziness which not many people are questioning (the intelligence levels in America has sunk to its lowest!) is the new American standard for drug approvals set by the US FDA under the Trump administration in which as long you can demonstrate somehow by whatever means that a drug is able to shorten hospitalization stays, Voila! You get approved and you can ...
Drugs-COVID-19: Spanish researchers from the Department of Cell Biology at the University of Malaga (UMA) and the Andalusian Centre for Nanomedicine and Biotechnology (BIONAND) have identified 4-Phenylbutiric acid or 4-PBA as a possible drug candidate to treat the various inflammatory and immune issues resulting from the SARS-CoV-2 coronavirus infection that causes COVID-19 disease.
The s...
Source: Coronavirus Supplements Sep 18, 2020 1 month ago
Coronavirus Supplements: Researchers from the University of Nebraska Medical Center and Center for Biologics Evaluation and Research (CBER), FDA, Silver Spring have demonstrated in vitro studies that bromelain extracted from pineapples is able to inhibit the SARS-CoV-2 coronavirus in Vero E6 cells via a multitude of ways.
The study findings are published on a preprint server and are...
Source: Coronavirus Antivirals Sep 17, 2020 1 month ago
Coronavirus Antivirals: Researchers from University of Chinese Academy of Sciences, Shanghai-China have identified the antibiotic Ceftazidime as possible antiviral candidate to inhibit SARS-CoV-2 coronavirus and treat the COVID-19 disease.
The research findings were published on a preprint server and have yet to be peer reviewed.
https://www.biorxiv.org/content/10.1101/2020.09.14.295956v1
...
Source: COVID-19 Immunotherapy Sep 17, 2020 1 month ago
COVID-19 Immunotherapy: Researchers from Corvus Pharmaceuticals Inc-California, Temple University-Philadelphia and Icahn School of Medicine at Mount Sinai-New York in a phase 1 clinical trial have demonstrated that using a Inhibitor Of CD73 Enzymatic Activity called CPI-006, the researchers were able to induce the effective B Cell and Humoral response to SARS-CoV-2 infection in COVID-19 patients e...
COVID-19 Meds: A new vitro study led by Austrian researchers from the University of Vienna has demonstrated that the nasal antihistamine Azelastine was able to inhibit SARS-CoV-2 infections in assays using reconstituted human nasal tissue and Vero E6 monkey kidney epithelial cells. The study team says that Azalastine is a prospective drug candidate that could be used to reduce viral transmission i...
COVID-19 Drugs: Azithromycin, a commonly-prescribed antibiotic that also is being investigated as a potential treatment for COVID-19 according to a new study by researchers from the University of Illinois Chicago, by itself is not associated with an increase in cardiac events; however, if taken with certain other drugs that affect the electrical functioning of the heart, then cardiac events increa...
COVID-19 Drugs: Researchers from the University of Pittsburgh School of Medicine claim to have isolated the smallest biological molecule to date that completely and specifically neutralizes the SARS-CoV-2 coronavirus.
The research findings were published in the journal: Cell https://www.cell.com/cell/pdf/S0092-8674(20)31148-X.pdf?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%...
Source: COVID-19 Breakthrough Sep 13, 2020 2 months ago
COVID-19 Breakthrough: Clinical-stage biopharmaceutical company Senhwa Biosciences that is based in Taiwan with offices in San Diego has announced that its investigational drug, Silmitasertib has demonstrated remarkable effectiveness after the first patient with severe COVID-19 demonstrated remarkable recovery after using the drug.
Senhwa Biosciences is a company focused on next generation DNA Da...
Source: COVID-19 Treatments Sep 12, 2020 2 months ago
COVID-19 Treatments: Researchers from Mississippi have in a new study found that utilizing both the antihistamines Cetirizine and Famotidine appears to reduce pulmonary symptoms and may have other benefits in patients with COVID-19.
The study findings were published in the journal: Pulmonary Pharmacology & Therapeutics https://www.sciencedirect.com/science/article/pii/S1094553920301462?...
Source: COVID-19 Convalescent Plasma Sep 10, 2020 2 months ago
COVID-19 Convalescent Plasma: An open-label, parallel-arm, phase II, multicentre, randomized controlled trial (PLACID) in India has shown that the use of convalescent plasma as a therapeutic for moderate COVID-19 patients showed no positive effects and did not improve the outcome of the patients.
The study findings are published on a preprint server and are currently being peer reviewed. ...
Source: Drugs And COVID-19 Sep 09, 2020 2 months ago
Drugs And COVID-19: Danish researchers led by Dr Anton Pottegård of the University of Southern Denmark along with other scientists from Aarhus University Hospital and the Danish Medicines Agency have in a new study found that the use of non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen and diclofenac, is not associated with any adverse effects in people who have tested p...
Drugs-COVID-19: Researchers from Memorial Sloan Kettering Cancer Center-New York in a new study suggest that using drugs such as PI3K/mTOR And Topoisomerase inhibitors reduces ACE2 expression and reduces risk and an individual’s susceptibility to the SARS-CoV-2 coronavirus that causes the COVID-19 disease.
As ACE2 are the main and first receptors that the SARS-CoV-2 coronavirus uses...
Source: Narsoplimab And COVID-19 Sep 06, 2020 2 months ago
Narsoplimab And COVID-19: Researchers are now saying that treatments for COVID-19 may be focusing on at the wrong elements of the disease based on emerging data from Bergamo, Italy, the epicenter of the pandemic in Europe.
Italian researchers realized, as they combed through the data, that COVID-19 is an endothelia injury rather than a pulmonary event and that stopping the complement casc...
Source: COVID-19 Bradykinin Storms Sep 03, 2020 2 months ago
By detailed analysis of data on more than 40,000 genes , 17,000 genetic and 2.5 billion genetic combinations samples linked to COVID-19, researchers from Oak Ridge National Lab in Tennessee have managed by using the world’s second fastest computer called the Summit supercomputer have come up with a hypothesis as to how the SARS-CoV-2 coronavirus affects the human host dubbed the &...
COVID-19 Drugs: Canadian researchers from the University of Alberta are preparing to launch clinical trials of a drug called GC376 ( A prodrug of the parent drug called GC373) used to cure a deadly disease caused by a coronavirus in cats and they expect will also be effective as a treatment for humans against COVID-19 after successful vitro studies.
The study findings or the vitro trials ...
Source: Nitric Oxide For COVID-19 Aug 27, 2020 2 months ago
Nitric Oxide For COVID-19: According to researchers from Massachusetts General Hospital (MGH), inhaled nitric oxide (NO) can be a valuable adjunct respiratory therapy for pregnant women with severe and critical COVID-19.
It was found that the delivery of the therapeutic gas to six COVID-19 pregnant patients admitted to MGH, resulted in a rapid and sustained improvement in cardiopulmonary function...
Source: COVID-19 Diagnostics Aug 27, 2020 2 months ago
COVID-19 Diagnostics: Researchers from Lawson Health Research Institute and Western University in a news study have identified six molecules that can be used as biomarkers to predict how severely ill a patient will become.
The research findings were published in the Journal: Critical Care Explorations, the official journal of the Society Of Critical Care Medicine https://journals.lww.com/...
Medical News: Estradiol, the estrogen steroid hormone might confer a certain degree of protection to females claims a new study by European and American reseachers.
According to a new study by researcher from Universitätsmedizin Berlin-Germany, Sapienza University of Rome-Italy, Sant’Andrea University Hospital-Italy and University of Virginia-USA, it appears that wome...
Source: Coronavirus Treatments Aug 26, 2020 2 months ago
Coronavirus Treatments: Japanese researchers from Japan’s National Institute of Infectious Diseases are banking their hopes on an inhaled steroid called ciclesonide as the drug has both antiviral and also anti-inflammatory properties against the SARS-CoV-2 coronavirus.
In a recent study, the study team reports the in vitro suppression of both the MERS coronavirus and also the SARS-Cov-2 cor...
Source: COVID-19 Treatments Aug 26, 2020 2 months ago
COVID-19 Treatments: A second clinical observation study, this time conducted by researchers from Harford hospital-Connecticut have demonstrated that administering famotidine to hospitalized COVID-19 patients was associated with a reduction in death and a composite endpoint of either death or intubation. The study involved 878 hospitalized COVID-19 patients of which 83 (9.5%) r...
COVID-19 News: According to new research from the University of East Anglia-UK, medication for high blood pressure could improve COVID-19 survival rates and reduce the severity of infection.
The study team meta-analyzed data from a variety of sources involving more than 28,000 patients taking antihypertensives, a class of drugs that are used to treat hypertension also known as high blood ...
COVID-19 News: Netherlands based Hercules Pharmaceuticals, a biopharmaceutical company focusing on developing small molecule inhibitors of the Aryl Hydrocarbon Receptor (AhR) for treatment of cancer and viral infections, has announced the publication of promising preclinical in-vivo trial results, showing efficacy of its Aryl Hydrocarbon Receptor (AhR) inhibitor HP163 against Zika virus infection ...
COVID-19 Drugs: A randomized control trial of inhaled corticosteroids (ICS) on COPD patients led researchers to discover that inhaled corticosteroids could downregulate the expression of ACE2 receptors in the bronchial epithelial cells and also the epithelial cells in the airways. Furthermore the inhaled corticosteroids were found to also inhibit a human host protease gene ADAM17 that plays ...
COVID-19 Drugs: Remdesivir has so far emerged as another controversial drug that was approved by the US FDA under the Trump administration for emergency use despite the fact that it not clearly demonstrated its efficacy against the SARS-CoV-2 coronavirus nor was there any long term safety studies ever conducted on it use. It was granted approval merely on the basis that it shortened hospitalizatio...
COVID-19 Drugs: Canadian researchers from Queen’s University-Ontario Novateur Ventures Inc.-Vancouver in a new study propose that two generic anti-inflammatory drugs, zileuton and montelukast typically used in asthma treatments, be used to treat COVID-19 patients because of their potential to dampen disease progression and severity.
The research findings were publi...
COVID-19 Drugs: Researchers from COVID-19 Radboud University Medical Center-Netherlands, University Medical Center Utrecht-Netherlands and University of Bonn-Germany in a new study have shown that patients with hypoxia responded positively to treatment with the drug lanadelumab, a Kinin B2 receptor antagonist.
These study findings have led to a follow-up study at ten Dutch hospi...
COVID-19 Drugs: Canadian based Bold Therapeutics, a clinical-stage biopharmaceutical company, have recently generated more key data supporting the rapid clinical development of a new therapeutic drug called BOLD-100 as an antiviral against the SARS-CoV-2 coronavirus.
The therapeutic drug BOLD-100 is a first-in-class ruthenium-based small molecule drug which selectively inhibits stress-ind...
COVID-19 Drugs: With global death rates now reaching more than 754,000 (168,000 just in America alone) and the official infected cases at more than 22 million, medical researchers are desperate to find drugs and treatment protocols that can at help reduce mortality rates. To date there is no real effective drugs that can really treat COVID-19 effectively (remdesivir ‘s efficacy is now being ...
Source: COVID-19 Treatments Aug 13, 2020 3 months ago
COVID-19 Treatments: University Of California-San Francisco scientists have developed a novel approach to halting the spread of SARS-CoV-2 involving an aerosol formulation of nanobodies that are basically antiviral molecules that inhibit the virus.
The research and development lead by graduate student Michael Schoof, along with a team of researchers engineered a completely synthetic...
Source: COVID-19 Herbs And Therapeutic Teas Aug 09, 2020 3 months ago
Therapeutic Teas is a range of herbal teas specially created for the COVID-19 crisis after 4 months of intense research and is still evolving daily based on emerging daily COVID-19 research.
3 blends have been created to date using a total of 25 herbs with 31 targeted phytochemicals present in these herbs.
The inspiration came from the Traditional Chinese Medicine formulations that...
Source: COVID-19 Warnings Aug 08, 2020 3 months ago
COVID-19 Warnings: Researchers from COVID-19 Infectious Diseases and Microbiology Unit, Hospital Universitario Virgen de Valme- Spain have discovered that the usage of the antivirals Lopinavir-Ritonavir (LPV-r ) can lead to numerous drug interactions that can be detrimental to health conditions and even cause death in certain situations as a result of these interactions.
Despite numerous st...
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