Source: COVID-19 Research Aug 04, 2020 23 hours ago
COVID-19 Research: Numerous new studies are emerging that shows high dose Vitamin C could be useful in treating COVID-19 patients after initial skepticisms by certain medical doctors and researchers linked to the big pharmaceutical companies who were most probably paying these unethical medical professionals.
In the early stages of the COVID-19 pandemic, results of an analysis published in the ...
COVID-19 Drugs: Researchers from Texas A & M University, University of Texas-Galveston and the University Of North Texas have identified a series of potent enzyme inhibitors that are able to suppress SARS-CoV-2 replication by interfering with one of the primary viral proteases.
The researchers urge rapid clinical and preclinical testing of their most potent compounds to meet the need ...
COVID-19 Drugs: Most people have a fallacy that tetracyclines only work as antibiotics without knowing that these drugs also possess immunomodulatory and anti-inflammatory properties as well.
The SARS-Cov-2 coronavirus seems to attack the human airway epithelium primarily. In severely affected patients, the illness progresses to hypoxemic respiratory failure and acute respiratory distress...
COVID-19 Drugs: Researchers from the Boston Children's Hospital and Brigham and Women's Hospital have launched a randomized, placebo-controlled clinical trial of dornase alfa (Pulmozyme) in patients with severe COVID-19 pneumonia and respiratory failure requiring mechanical ventilation.
The protein Dornase alfa (proprietary name Pulmozyme from Genentech) is a h...
COVID-19 Drugs: Researchers from Yale School of Medicine and the biopharmaceutical firm AI Therapeutics have launched a multi-institutional clinical trial of a drug for treating COVID-19.
The drug known as LAM-002A (apilimod), has a proven safety record. Preliminary research has shown it can block cellular entry and trafficking of the SARS-CoV-2 virus, the cause of COVID-19.
Past t...
COVID-19 Drugs: Researchers from Rensselaer Polytechnic Institute-New York, Korea Research Institute of Bioscience and Biotechnology, and Zhejiang University of Technology-China in study involving the test of antiviral effectiveness against the virus that causes COVID-19, found that an extract from edible seaweeds called fucoidan substantially outperformed remdesivir, the current standard antivira...
COVID-19 Drugs: Heron Therapeutics, Inc, a commercial-stage biotechnology company announced the initiation of the GUARDS-1 Study, a Phase 2 clinical study evaluating CINVANTI (aprepitant) injectable emulsion in early hospitalized patients with COVID-19.
The research study initiation follows clearance from the U.S. FDA of Heron's Investigational New Drug application for CINVANTI for th...
COVID-19 Drugs: Biophramaceutical company Sorrento Therapeutics, Inc. has received clearance from the US FDA to initiate a Phase 2 trial of Abivertinib in patients with COVID-19 who have moderate to severe pulmonary symptoms.
The drug Abivertinib is a novel small molecule tyrosine kinase inhibitor (TKI) that selectively targets both mutant forms of the epidermal growth factor receptor (EG...
Source: COVID-19 Scandals Jul 22, 2020 14 days ago
COVID-19 Scandals: Remdesivir is coming under more spotlight as more doctors questions its effectiveness not only in terms of its ability to cut death rates but also on its claims to shorten hospitalization stays. https://www.bmj.com/content/370/bmj.m2839
Many subsequent studies that emerged after the criticisms seems suspicious as some look as if the researchers or institutions wer...
COVID-19 Drugs: According to researchers from the George Washington University (GW), nitric oxide treatment can be pivotal in the world's fight against SARS-CoV-2, the coronavirus that causes COVID-19. A review article on its usage is published in the journal Nitric Oxide. https://www.sciencedirect.com/science/article/pii/S1089860320301701?via%3Dihub
As a pharmaceutical compound,...
Source: COVID-19 Medications Jul 20, 2020 16 days ago
COVID-19 Medications: Synairgen, a British biotech company announced positive results from a clinical trial of its wholly-owned inhaled formulation of interferon beta in COVID-19 patients.
Synairgen indicated its nebulizer treatment resulted in a 79% lower risk of patients developing severe disease compared to those receiving a placebo. And the patients receiving the treatment &...
COVID-19 Drugs: Leading Biopharmaceuticals company Biocon has secured approval from the Drugs Controller General of India (DCGI) for its plaque psoriasis drug Itolizumab (ALZUMAb) for emergency use in Covid-19 patients.
The regulatory approval is for 25mg / 5ml injection solution of the medicine to treat cytokine release syndrome (CRS) in moderate to severe acute respiratory distress synd...
COVID-19 Drugs: Dexamethasone’s much-awaited official results from a UK trial of the steroid dexamethasone were published finally a few hours ago in the New England Journal of Medicine, confirming its life-saving benefits for COVID-19 patients on ventilators but suggesting it may cause harm if given too early. https://www.nejm.org/doi/full/10.1056/NEJMoa2021436?query=featured_home
In...
COVID-19 Drugs: A research team led by Hebrew University of Jerusalem (HU)'s Professor Dr Yaakov Nahmias says that a simple and inexpensive cholesterol-lowering drug called Fenofibrate (Tricor) that is been approved and on the market for decades could help downgrade the severity of COVID-19 disease.
The early research finding which looks promising has been published in the preprint section of...
COVID-19 Drugs: Heparin, a common drug, already approved by the US as an anticoagulant may also be a powerful tool in fighting COVID-19, according to research published in the journal: Antiviral Research. https://www.sciencedirect.com/science/article/abs/pii/S0166354220302874?via%3Dihub
The SARS-CoV-2, the virus that causes COVID-19, uses a surface spike protein to latch onto human c...
COVID-19 Drugs: A relatively large and detailed clinical trial performed by Japanese researchers has showed inconclusive data from Covid-19 patients treated with Fujifilm’s Avigan drug also known as favipiravir. Fujita Health University researcher Professor Dr Yohei Doi said that the drug led to improvement in patients treated early, compared to those who received delayed dose...
Source: COVID-19 Cellular Therapy Jul 13, 2020 23 days ago
COVID-19 Cellular Therapy. Spanish researchers announced that a cellular therapy tested on 13 intubated patients with mechanical ventilation has shown to be efficient for the clinical improvement of critical cases of COVID-19.
The research which is the broadest published to date in these conditions, has been published in journal: The Lancet's EClinical Medicine, after proving that the...
COVID-19 Meds: With more than 140 vaccine projects and more than 420 drug trials under way and governments in Europe and the United States investing billions of dollars in research, trials and manufacturing, there is concern that richer nations could scoop up promising medicines against the new coronavirus, leaving developing countries empty-handed.
Bill Gates, Billionaire philanthropist (wish h...
Remdesivir: Pharma giant Gilead Sciences wasted no time beginning testing of an inhaled formulation of its COVID-19 drug remdesivir for mild and less severe COVID-19 patients with the hope that the US FDA and Trump administration will support its approval again and buy up overpriced stocks once again with tax payers monies. We are not sure what basis the inhaled version of the drug will be approve...
Source: COVID-19 Controversies Jul 10, 2020 26 days ago
COVID-19 Controversies: Despite the fact that Pharmaceutical giant Gilead has huge resources and research facilities, it was never demonstrated that Remdesivir had any direct effects in terms of inhibiting the SARS-CoV-2 replication capability in vitro or vivo studies. The only things it had that made the Trump administration pass the FDA approval as a drug for COVID-19 was 'half-baked' st...
COVID-19 Drugs: Despite numerous studies showing that Lopinavir and Ritonavir are not effective to treat COVID-19, we still have numerous ignorant countries and doctors still using those drugs in their treatment protocols.
Now a new French study shows that older, critically ill patients with COVID-19 who received a combination of the antiretroviral medications lopinavir and ritonavir experienced ...
COVID-19 Drugs: There is now an increased demand for a variety of drugs to treat the growing variety of symptoms and conditions associated with COVID-19. One of which is the assortment of different types of neurological conditions. Just for one neurological category of symptoms which is delirium, BioXcel Therapeutics, which is based in Connecticut has developed a new drug called BXCL510.
...
COVID-19 Drugs: R-Pharm, a Russian pharmaceutical company has secured regulatory approval for the use of its antiviral drug Coronavir, to treat patients suffering from Covid-19. The company released the announcement today to Russian media.
The regulatory approval comes after a clinical trial in mild to moderate Covid-19 patients showed that the drug is highly effective in blocking replica...
COVID-19 Drugs: Medical researchers from Queensland University of Technology and Oxford University are working in collaboration to begin human clinical trials of inhaled corticosteroids, commonly used for asthma patients, on patients with COVID-19. The researchers believe that this could be useful for patients with the novel coronavirus infection.
Research has shown that some corticosteroids,&nbs...
COVID-19 Drugs: Researchers from University of South Florida Health (USF Health) Morsani College of Medicine scientists along with pharmaceutical experts from the University of Arizona College of Pharmacy have identified several existing drug compounds that block replication of the COVID-19 virus (SARS-CoV-2) within human cells grown in the laboratory. The identified inhibitors all demon...
Source: Generic Remdesivir Jul 06, 2020 1 month ago
Generic Remdesivir: The Trump administration last week proudly announced that it had secured 500,000 doses of Gilead’s remdesivir at prices that were set by Gilead at between US$2,340 to US$3,120. https://www.thailandmedical.news/news/breaking-remdesivir-gilead-sets-price-at-us$2,340-to-us$3,120-for-drug-that-has-no-safety-studies-or-true-efficacy-except-that-it-shortens-hospitaliza
...
COVID-19 Pharma News: Pharma giant Merck, a leading science and technology company, announced that the US FDA has cleared its investigational new drug application (IND) for M5049 for the treatment of patients with Covid-19 pneumonia. Merck will initiate a Phase II randomized, controlled clinical study evaluating the safety and efficacy of M5049 in this patient population. M5049 is a potentially fi...
Source: Melatonin and COVID-19 Jul 05, 2020 1 month ago
Melatonin and COVID-19: Another study by researchers from Peking Union Medical College in China and the University of Texas- San Antonio in America have in a new peer-reviewed finding that is published in the journal: Life Sciences By Science Direct, propose that Melatonin should be incorporated as an adjuvant treatment for COVID-19 as it has proven mechanisms to target Inflammasomes that triggers...
Source: COVID-19 Clinical Care Jul 04, 2020 1 month ago
COVID-19 Clinical Care: Researchers are expressing that more safety data is needed in terms of treatment of symptomatic COVID-19 patients on antivirals with anticancer drugs.
A report published in the European Journal of Cancer by a group of French investigators led by Dr Paul Gougis of the Department of pharmacology, Hôpital Pitié-Salpêtrière in Paris, Franc...
COVID-19 Drugs: EUSA Pharma has secured approval from the U.S. Food & Drug Administration (FDA) for a Phase III clinical trial protocol of intravenous siltuximab plus standard of care in hospitalized patients with Covid-19 associated Acute Respiratory Distress Syndrome (ARDS).
The pharmaceutical company will now proceed with the randomized, double-blind, placebo-controlled clinical trial to e...
COVID-19 Drugs and Erythropoietin: German researchers from the Max Planck Institute of Experimental Medicine in Göttingen suggest that the anemia drug Erythropoietin (Epo) which is sometimes misused as doping agent could also be effective against COVID-19.
EPO, the growth factor could also mitigate severe disease progression and protect patients from long-term neurological effects when the ...
COVID-19 Drugs: Researchers from the University of North Carolina (UNC) have used a new web-based platform to help identify synergistic and antagonistic drug combinations and their underlying mechanisms of action in the context of fighting the SARS-CoV-2 coronavirus disease.
The data mining tool, called COVID-KOP, prioritized 73 combinations of 32 drugs as potential treatments for COVID-1...
Source: COVID-19 Drugs and Fostamatinib Jul 02, 2020 1 month ago
COVID-19 Drugs: Fostamatinib, an FDA-approved monoclonal antibody that is a spleen tyrosine kinase inhibitor (SYK), was studied by researchers from Harvards’ Broad Institute, Imperial College’s Hammersmith Hospital, Brigham and Women’s Hospital and Harvard Medical School for possible use to reduce the levels of mucin-1, a molecule associated with acute lung injury and acute respi...
Source: COVID-19 Clinical Trials Jul 01, 2020 1 month ago
COVID-19 Clinical Trials: Researchers from RCSI University of Medicine and Health Sciences-Ireland have begun a clinical trial of a promising therapy for critically ill COVID-19 patients in intensive care.
A study published in the American Journal of Respiratory and Critical Care Medicine by the team led by RCSI Professors Dr Gerry McElvaney and Dr Ger Curley, describe changes in the...
COVID-19 Drugs: The SARS-CoV-2 coronavirus typically uses a protein called polymerase to replicate its genome inside infected human cells. Studies have shown that terminating the polymerase reaction will stop the growth of the coronavirus, leading to its eradication by the human host's immune system.
Now researchers from Columbia University and the University of Wisconsin-Madison have...
COVID-19 Drugs: More emerging results from the ongoing international RECOVERY Trail project shows that Lopinavir-Ritonavir has no clinical benefits in hospitalized COVID-19 treatments. Readers should also take note that in February 2020, Thai ‘medical experts’ held a huge press conference to announce that they had invented a treatment protocol to treat COVID-19 using Lopinavir-Ritonavi...
Source: Remdesivir and COVID-19 Jun 30, 2020 1 month ago
Remdesivir: No one is sure yet as to how much certain family members of Trump or the relatives of the US FDA could be making, but its interesting to see that the US FDA under the Trump administration had approved a drug to treat COVID-19 despite the fact there are no true detailed safety studies on the drug and also the fact there is no real efficacy demonstrated except that it shortens hospitaliz...
Source: COVID-19 Drugs & Vaccines Jun 29, 2020 1 month ago
COVID-19 Drugs And Vaccines: As the total number of global confirmed COVID-19 Infections reaches 10,267, 578 and the total confirmed deaths due to the SARS-CoV-2 coronavirus reaches 504, 812 (29th June, 2.45am California), people everywhere and healthcare professionals are getting more anxious as to date there are no real confirmed drugs or treatments protocols that can really treat COVID-19 effec...
Source: COVID-19 Treatments Jun 28, 2020 1 month ago
COVID-19 Treatments: The oral administration of the amino-acids Cysteine and Theanine could attenuate SARS-CoV-2 viral infection, replication and associated symptoms of COVID-19 such as cytokine storm according to Japanese researchers from the Research Institute for Bioscience Products & Fine Chemicals, Ajinomoto Co., Inc.
The preprint study that is yet to be peer-reviewed is publishe...
Source: Occulus Hirsutus and AQCH Jun 27, 2020 1 month ago
Occulus Hirsutus and AQCH: For the past 4 months India has been secretly working with teams of medical, biotech, biomolecular and pharmaceutical experts in developing an antiviral drug to treat COVID-19 using extracted phytochemicals from the Occulus Hirsutus plant.
The plant Cocculus hirsutus (Linn.) Diels (Menispermaceae), described in traditional indian medicine ayurvedic literatu...
Source: Colchicine And COVID-19 Jun 25, 2020 1 month ago
Colchicine and COVID-19: Greek researchers have reported success in a small early clinical trial using an ancient drug called Colchicine to treat patients with severe COVID-19.
The clinical trial results were published yesterday in the journal: JAMA Network Open. https://jamanetwork.com/searchresults?q=Spyridon%20Deftereos&f_SiteID=214&SearchSourceType=3&exPrm_qqq={!payloadDisMaxQPars...
Source: Favipiravir And COVID-19 Jun 23, 2020 1 month ago
Favipiravir: The COVID-19 pandemic has made the medical and pharmaceutical world one big circus with many charlatans including Government authorities for the sake of greed, power or ego endorsing drugs that do not have any proven efficacy to treat the COVID-19 disease let alone safety studies done on their usage. One example is hydroxychloroquine and we are not going to elaborate on it here as eve...
COVID-19-Drugs: German researchers from Marburg University Hospital claim that the cancer drug ruxolitinib is able to stop inflammatory processes in COVID-19 patients with acute respiratory syndrome (ARDS).
Their research findings were published in the journal: Nature https://www.nature.com/articles/s41375-020-0907-9
Dr Thomas Wiesmann who is from intensive care team in the D...
Source: COVID-19 Natural Cures Jun 22, 2020 1 month ago
COVID-19 Natural Cures: Researchers from the University of Alabama in Huntsville (UAH) has identified 125 naturally occurring compounds that have a computational potential for efficacy against the COVID-19 virus from the first batch of 50,000 compounds rapidly assessed by a supercomputer.
A supercomputer is being utilized to assess the treatment efficacy of naturally occurring compounds a...
Source: Ivermectin And COVID-19 Jun 21, 2020 2 months ago
Ivermectin and COVID-19: Despite initial molecular docking studies and vitro studies showing a potential of using Ivermectin to treat COVID-19, there has only been a few clinical trials and even then despite having positive results, not much is talked about Ivermectin as its basically a drug whose patent has lapsed and hence it is not profitable for many pharmaceutical giants to promote it. To als...
Source: Azithromycin and COVID-19 Jun 21, 2020 2 months ago
Azithromycin: In a new study published in the Oxford Journal: Open Forum Infectious Disease, researchers Dr Jeniffer Lighter and Dr Vanessa Raabe from New York University School of Medicine warn against the use of the antibiotic azithromycin to treat COVID-19. https://academic.oup.com/ofid/article/7/6/ofaa207/5849083
In the mad scramble to find drugs to treat COVId-19 and the testing of v...
Source: Cannabis And COVID-19 Jun 20, 2020 2 months ago
Cannabis And COVID-19: According to researchers from Harvard Medical School, Northeastern University, Concordia University of Wisconsin and Vilotos Pharmaceuticals Inc, Caflanone (FBL-03G) a flavonoid extracted from a rare strain of cannabis found in Jamaica called Black Swan could hold therapeutic properties to treat COVID-19.
The research findings were published in the journal : Molecul...
Source: Tocilizumab or Actemra Jun 18, 2020 2 months ago
Tocilizumab: Pharma giant Roche’s rheumatoid arthritis drug, Actemra (Tocilizumab) failed to help COVID-19 patients in Italian study according to the clinical trial findings released today.
The drug failed to help patients with early-stage COVID-19 pneumonia in an Italian study, the latest instance in another an anti-inflammatory drug has fallen through in a coronavirus ...
WHO: The World Health Organization finally decided Wednesday to halt all trials of hydroxychloroquine as a potential treatment for hospitalized COVID-19 patients, finding it did not reduce the mortality rate.
The malaria and rheumatoid arthritis drug, hydroxychloroquine has been at the center of political and scientific controversy.
It has been touted as a possible treatment for th...
Source: Remdesivir and COVID-19 Jun 16, 2020 2 months ago
Remdesivir: The American Food and Drug Administration has issued a warning to doctors and all healthcare professionals about a newly discovered potential drug interaction related to the investigational antiviral drug remdesivir, an antiviral drug that is being evaluated as a potential treatment for the novel coronavirus disease 2019 (COVID-19) and has also been granted emergency use authoriz...
Source: Hydroxychloroquine And Chloroquine Jun 16, 2020 2 months ago
Hydroxychloroquine: U.S. regulators finally on Monday revoked emergency authorization for malaria drugs hydroxychloroquine and chloroquine promoted by scammers for treating COVID-19 amid evidence these drugs do not work and are in fact lethal in certain cases and causes serious side effects.
Strangely the official revocation of the drug to treat COVID-19 was done on a very low...
Source: COVID-19 Antibodies Jun 16, 2020 2 months ago
COVID-19 Antibodies: A team led by Scripps Research including scientists from University of California-SanDiego, University Of Washington, Harvard University and International AIDS Vaccine Initiative (IAVI)-New York has discovered a type of antibodies in the blood of recovered COVID-19 patients that provide powerful protection against SARS-CoV-2 coronavirus when tested in animals and human c...
Source: COVID-19 Research Jun 16, 2020 2 months ago
COVID-19 Research: A new research led by Norwegian University of Science and Technology involving both Norwegian and Estonian researchers have established a cell culture that allows them to test antibody-laden plasma, drugs and drug combinations in the laboratory. The team also identified six potential antiviral candidates out of a base of 136 already approved drugs that could be repurposed. One c...
Source: COVID-19 Convalescent Plasma and Hyperimmune Plasma Or H-Ig Therapies Jun 15, 2020 2 months ago
Convalescent Plasma: In an attempt to treat COVID-19, there have been numerous studies and trials to treat COVID-19 involving convalescent plasma transfusions but most have produced only mediocre results. Biotech companies working in the plasma space are now collaborating to develop a hyperimmune Ig therapy which could product produce better results.
Typically, plasma is the liquid compon...
Source: Niclosamide & COVID-19 Jun 13, 2020 2 months ago
Niclosamide & COVID-19: In a few preprint studies involving computational drug repurposing studies, niclosamide, an approved parasiticide drug was identified as a potential candidate. https://aac.asm.org/content/early/2020/04/28/AAC.00819-20
Past studies had also showed that it did have efficacy against the SARS-CoV-2 coronavirus in vitro studies and also another study published in Sc...
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