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A section specially dedicated to Long COVID or PASC ie Post-acute Sequelae of COVID-19. The section on Long COVID will cover all the latest research and developments about Long COVID or PASC and also provide guidelines to all long haulers about the new treatment protocols and therapeutics available for long COVID or Post-acute Sequelae of COVID-19 (PASC). Long COVID is expected to become a major h...
Researchers have identified a combined brain-and-cognition pattern that distinguishes people with Long COVID from healthy controls, pointing toward subtle neuroinflammatory and vascular changes rather than widespread neurodegeneration.
Advanced MRI and cognitive testing linked Long COVID symptoms with subtle brain changes consistent
with neuroinflammatory and vascular processes
The ...
COVID-19 may affect sexual and reproductive health through a surprisingly broad combination of vascular, hormonal, inflammatory, reproductive, and psychological pathways, according to a large systematic review.
A systematic review finds COVID-19 can affect sexual function, sperm quality, hormones, and menstrual health,
although many reproductive changes appear temporary
Researchers examin...
SARS-CoV-2 spike proteins from the Alpha, Delta, and Omicron variants can trigger distinctly different structural and molecular changes in human heart muscle cells, according to new laboratory research examining how viral proteins affect the cellular machinery needed for normal cardiac function.
Alpha, Delta, and Omicron spike proteins produced different structural and molecular remodeling pa...
A little-studied herpesvirus may deserve closer attention in long COVID research after scientists found strikingly high HHV-7 positivity among patients experiencing persistent neurological and neuropsychiatric symptoms following SARS-CoV-2 infection.
HHV-7 positivity reached 76.7% among patients with neurological or neuropsychiatric long COVID in a retrospective study
Research institutions...
Scientists investigating why COVID-19 can increase the risk of dangerous blood clots have discovered unusually high levels of cell-free hemoglobin and iron inside cerebral thrombi removed from stroke patients.
COVID-19-associated stroke clots contained unusually high levels of cell-free hemoglobin and iron, revealing
a potential new mechanism contributing to abnormal blood clotting
...
A newly published scientific review is drawing attention to a potentially important biological connection between COVID-19, disrupted fat metabolism, and long-term neurological damage. Researchers argue that changes involving the SARS-CoV-2 receptor ACE2 and cellular lipids could help explain why neurological problems persist in some people with Long COVID and may overlap with pathways involved in...
Scientists are investigating whether SARS-CoV-2 proteins that remain in the body long after an acute infection could help explain why some people develop persistent, multisystem symptoms known as Long COVID.
Persistent SARS-CoV-2 antigens detected months after infection are being investigated as one possible
contributor to Long COVID
The review was conducted by Elifcan Aladag and Ib...
A large study suggests COVID-19 may leave people with type 2 diabetes facing elevated risks of vitamin and mineral deficiencies for years after infection, alongside higher rates of osteoporosis and fractures.
Researchers I-Wen Chen, Li-Chen Chang, and Kuo-Chuan Hung analyzed electronic health records from the predominantly U.S.-based TriNetX Global Collaborative Network. The researchers a...
Acute respiratory infections such as influenza and COVID-19 could have unexpected consequences for people with dormant cancer cells, with mounting evidence suggesting that infection-driven inflammation can alter the body's immune environment in ways that allow previously inactive cancer cells to awaken and grow.
Acute influenza and COVID-19 inflammation may awaken dormant cancer cells and...
A scientific review focuses on ion channels and virus-made membrane proteins that may help SARS-CoV-2 replicate, disrupt cells, provoke inflammation and possibly contribute to persistent illness.
SARS-CoV-2 viroporins, particularly the E protein, may disrupt cellular ion balance and expose new
therapeutic targets
Researchers Faisal F. Alousi and Abdel A. Alli examined evidence surro...
A major systematic review has brought together evidence of a rare but potentially serious form of muscle damage reported in people with SARS-CoV-2 infection and, much less frequently, following COVID-19 vaccination.
A systematic review found rhabdomyolysis reported during COVID-19 infection and in rare cases following vaccination,
although vaccine causality has not been established.
Resea...
Neuropsychiatric symptoms in people hospitalized with COVID-19 may be less an isolated brain problem than part of wider multi-organ illness, according to a Romanian study that found kidney and urinary-system involvement carried greater prognostic weight for intensive care and death.
COVID-19 neurological symptoms often appeared within broader multi-organ disease, while renal-urinary
involvem...
An Israeli study examining internal pharmacovigilance records has raised questions about how quickly an emerging myocarditis and pericarditis safety signal was communicated during the early COVID-19 vaccination campaign.
Researchers Yaakov Ophir, affiliated with Ariel University in Israel and the University of Cambridge in the United Kingdom, and Yaffa Shir-Raz of the University of Haifa in Israe...
Scientists are calling for more rigorous research into possible connections between cancer, SARS-CoV-2 infection, and COVID-19 vaccination after a major review identified recurring cancer-related signals in published medical literature from around the world.
Scientists examining worldwide evidence say cancer signals reported after COVID-19 infection and vaccination
require further investigat...
A study of people living with severe long COVID for about three years has found no evidence that three circulating markers of NETosis—a process linked to immune activation and inflammation—remain elevated long after SARS-CoV-2 infection. The findings challenge the idea that persistent systemic NETosis is a universal driver of long-term long COVID.
NETosis is a specialized form...
A newly identified population of dysfunctional immune cells may persist for months after acute COVID-19, offering fresh evidence that SARS-CoV-2 can leave measurable changes in the immune system well beyond the initial infection.
Researchers found that COVID-19 was associated with an expansion of unusual monocytes—white blood cells that help coordinate inflammation, destroy microbes, and de...
Cognitive problems following COVID-19 may linger far longer than patients realize, with new research finding that difficulties involving attention and psychomotor speed remained strikingly common during extended follow-up.
Researchers studying adults months and even years after COVID-19 found that approximately two-thirds showed objective impairment in attention and psychomotor functioning. Impor...
Kidney problems linked to COVID-19 may persist for at least six months, particularly among people sick enough to require hospitalization, according to a prospective Swedish study that tracked both filtering function and signs of tubular injury.
Hospitalized COVID-19 patients showed signs of impaired kidney function and persistent tubular injury for up to six months
after infection
R...
Researchers have uncovered a potential “dual-hit” mechanism by which SARS-CoV-2 may intensify harmful inflammation: the virus activates a major inflammatory pathway while weakening vitamin D receptor signaling that normally helps restrain immune responses.
Researchers found that SARS-CoV-2 may disrupt vitamin D receptor signaling while driving IL-6 inflammation, with
calcitriol s...
COVID-19 may have lasting consequences for the eyes of people with type 2 diabetes, with a massive multicenter study finding that patients with recorded SARS-CoV-2 infection had a substantially higher subsequent risk of diabetic retinopathy, including potentially vision-threatening forms of the disease.
COVID-19 was associated with increased subsequent diabetic retinopathy risk among adults w...
Organizing pneumonia is an inflammatory lung condition in which healing tissue develops inside the tiny airways and air sacs, interfering with normal lung function. Despite its name, it is not pneumonia caused directly by bacteria. It can develop after infections and other lung injuries, including COVID-19. In COVID-related organizing pneumonia, patients may experience persistent cough, shortness ...
Researchers have uncovered evidence that SARS-CoV-2 depends heavily on disabling stress granules, a cellular defense system that can halt protein production and interfere with viral replication. Disrupting two viral mechanisms that suppress these granules weakened the virus while still producing protection against later infection.
Blocking two SARS-CoV-2 stress-granule defenses reduced replic...
Fungal infections emerging alongside COVID-19 can dramatically complicate severe disease, particularly among critically ill patients, according to a major new scientific review examining the mechanisms, diagnosis, risk factors, and treatment of these potentially deadly co-infections.
Researchers warn that invasive fungal infections can exploit COVID-19-related immune dysfunction and tissue
d...
COVID-19 infection may leave measurable changes in blood lipid levels among adults with type 2 diabetes (T2D), while having little lasting impact on blood sugar control, according to a large retrospective study from Saudi Arabia.
COVID-19 was linked to small reductions in several blood lipids while long-term blood sugar markers remained stable in
adults with type 2 diabetes
Researchers an...
Scientists have uncovered a previously unknown mechanism by which SARS-CoV-2 may drive damaging inflammatory responses, identifying a viral protein-host protein interaction that could potentially become a new therapeutic target for severe COVID-19.
Researchers discovered how a SARS-CoV-2 protein can disable a natural neutrophil brake, potentially
fueling excessive inflammation and lung damag...
A major American study has uncovered new evidence explaining how COVID-19 can push the immune system into attacking the body itself, with researchers discovering that SARS-CoV-2 can activate immune pathways strikingly similar to those involved in lupus DN2s.
American researchers have identified lupus-like immune pathways that may explain how COVID-19 triggers harmful
autoantibodies and post-infe...
A worrying rise in the most dangerous form of herpes simplex virus (HSV) infection among newborn babies has emerged following the COVID-19 pandemic, according to a large 16-year study from Northern California. Researchers found that disseminated HSV, in which infection spreads through the body and can affect multiple organs, increased sharply after 2021.
A major study found a sharp post-pande...
Post-exertional malaise (PEM), a potentially disabling worsening of symptoms following physical or mental activity, was reported by about one in five New York City adults with a history of COVID-19, according to a large population-representative survey.
A large NYC survey found post-exertional malaise in about one-fifth of adults with prior COVID, with strong associations with
disability
&n...
Researchers studying an experimental magnetic therapy for people with Long COVID-related cognitive impairment have identified distinctive changes in blood proteins among participants classified as treatment responders.
The exploratory findings do not establish that Microtesla Magnetic Therapy (MMT) causes these biological changes or prove that it is an effective treatment for Long COVID. ...
Researchers in Germany have identified a pattern of proteins on circulating extracellular vesicles that could help distinguish people with post-COVID-19 syndrome from those who recovered completely, raising hopes for a future blood-based biomarker.
Scientists have identified a multivariable plasma extracellular-vesicle signature that may help distinguish Long COVID from complete recovery
&nb...
Scientists have identified a group of antiviral proteins produced during acute respiratory infections that may influence whether patients later develop persistent neurocognitive problems associated with Long COVID.
Strong antiviral protein responses during acute COVID-19 may reduce the risk of persistent neurocognitive symptoms
including brain fog
The findings suggest that the stren...
Researchers have uncovered a potentially important mechanism behind the abnormal blood clotting associated with COVID-19, finding unusually high levels of cell-free hemoglobin and iron inside cerebral blood clots removed from stroke patients infected during the pre-Omicron period.
Cell-Free Hemoglobin and Iron May Drive COVID-19 Stroke Clots
The findings suggest that damage to red blood ce...
A new laboratory study suggests that SARS-CoV-2 may damage the blood-brain barrier even when the virus does not actively infect the cells forming this crucial protective boundary. The findings could help explain how inflammation contributes to neurological problems during and after COVID-19.
SARS-CoV-2 spike protein disrupted a human blood-brain barrier model and triggered inflammation even
with...
A new scientific review suggests that damage to mitochondria—the structures that generate most of a cell’s usable energy—could be an important link between SARS-CoV-2 infection and the persistent fatigue, muscle weakness, cardiovascular problems, and neurological symptoms seen in post-COVID-19 condition, commonly called Long COVID.
Mitochondrial dysfunction may help explain the...
Distinct Immune Responses Emerge Early
A new multicohort study has uncovered striking differences in antibody responses to human herpesvirus 6 (HHV-6) during and shortly after SARS-CoV-2 infection, potentially offering new clues to why some people develop long COVID while others recover.
Distinct early HHV-6 IgA and IgG antibody patterns may help explain biological differences among people w...
Scientists are drawing growing attention to microscopic packages released by human cells that could help explain why inflammation, fatigue, vascular problems, and neurological symptoms can persist long after an acute SARS-CoV-2 infection has ended.
Tiny extracellular vesicles carrying protected viral and inflammatory cargo may help sustain several biological processes
associated with long CO...
COVID-19 is widely associated with pneumonia, respiratory distress, and lung injury, but mounting pathological and clinical evidence shows that SARS-CoV-2 can also seriously affect the spleen. This often-overlooked organ can undergo immune-cell depletion, structural deterioration, vascular injury, and potentially devastating infarction.
COVID-19 can quietly damage the spleen through immune-ce...
Thai medical researchers have reported an unusual case of a rare retinal disorder developing after COVID-19 infection, raising questions about whether infection could potentially trigger certain eye problems in susceptible people.
Thai researchers reported an unusual case of rare retinal disease developing after COVID-19 infection
Rare Eye Disease Appeared After COVID-19
The conditi...
Study Examines Children with Previous SARS-CoV-2 Infection
A new study involving 260 hospitalized children with evidence of previous SARS-CoV-2 infection has revealed notable differences in vitamin D levels, body weight, inflammation, blood markers, and lifestyle habits.
Children with previous COVID-19 showed substantial differences in vitamin D, body weight, inflammation, and other
nutriti...
Higher levels of COVID-19 circulating in communities may be followed by a measurable rise in serious blood clots in the lungs, with the strongest increase appearing about three weeks later, according to a large population study from Ontario, Canada.
COVID-19 activity was associated with increased pulmonary embolism hospitalizations, with the strongest risk
appearing around three weeks later
...
Long COVID may be creating a substantial pain burden among young adults, with new research finding that about four in ten nursing students with the condition experienced pain months after their initial COVID-19 infection.
New research finds pain affects about four in ten young nursing students with Long COVID, with headaches, fatigue, and gastrointestinal problems standing out
The st...
A new case report has documented unusual differences in brain perfusion in a woman experiencing persistent brain fog, dizziness, vertigo, and balance problems following COVID-19, raising further questions about how Long COVID may affect brain function even when conventional examinations provide few answers.
Brain SPECT imaging revealed a mixed pattern of relative perfusion differences in a pa...
A new systematic review suggests COVID-19 can be followed by adrenal insufficiency in people who had no previous adrenal disease. The condition can potentially become life-threatening because the body does not produce enough cortisol, a hormone essential for maintaining blood pressure and helping the body respond to physical stress.
A systematic review suggests COVID-19 may rarely be followed...
A new study has found striking evidence that people with Long COVID may continue to have unusually fast blood-clotting activity alongside increased numbers of abnormal microclot complexes and platelet-related material in their plasma.
New research links Long COVID with faster blood clotting, increased amyloid-like microclot complexes, and elevated
platelet-associated material.
The researc...
COVID 19 Detection Rate Climbs Rapidly
South Korea is facing growing concerns over a possible COVID-19 resurgence as national respiratory surveillance shows a sharp increase in coronavirus detections.
Rising COVID-19 detections and hospitalizations are fueling concerns that South Korea could be heading toward
another coronavirus resurgence
According to Korea Disease Control and Prevention Agenc...
Long COVID could cause measurable changes in brain circuitry while contributing to persistent memory problems, poor concentration, fatigue, anxiety, and depression, according to a new scientific editorial examining seven studies on the neurological and psychiatric consequences of COVID-19.
Long COVID research reveals changes in brain circuitry alongside measurable memory, attention, anxiety, ...
A new Italian study has found that severe COVID-19 is closely associated with major changes in inflammation and the way the body handles iron, potentially offering scientists a clearer picture of why some patients become critically ill.
The research involved 144 hospitalized COVID-19 patients and 139 COVID-19-negative vaccinated controls. Patients were divided into four groups, ranging from those...
Scientists investigating long COVID have identified a distinctive pattern of tiny gene-regulating molecules in the blood that may help explain why symptoms continue long after the initial coronavirus infection has ended.
Scientists found major differences in blood microRNAs that could provide new clues to the biological processes
driving persistent long COVID symptoms
The study exam...
COVID-19 is best known as a respiratory infection, but a new literature review suggests the disease is also be linked to subtle changes in the tiny blood vessels supplying the retina and choroid in children. The review also examined multisystem inflammatory syndrome in children, or MIS-C, an inflammatory condition that can develop after SARS-CoV-2 infection.
Advanced eye imaging suggests COVI...
COVID-19 is best known as a respiratory illness, but its effects can extend well beyond the lungs. Research suggests that severe infection can interfere with antidiuretic hormone (ADH), also called arginine vasopressin, potentially disturbing the body's careful control of water and sodium.
COVID-19 may disrupt ADH activity and sodium balance, contributing to hyponatremia and potentially seri...
A new study of older adults with neurologic long COVID has uncovered unusual changes in immune cells that may help explain why some people continue to experience brain fog months after infection.
Neurologic long COVID was linked to mitochondrial stress and disrupted coordination between key immune cells involved
in cognition
Neuro-PASC, the neurologic form of post-acute sequelae of SARS-C...
A form of magnetic brain stimulation used to treat major depression may be considerably less effective in people whose depression developed alongside Long COVID, according to a new study comparing treatment outcomes in carefully matched patients.
Long COVID-related depression showed substantially lower improvement and remission following magnetic brain stimulation than conventional major depr...
A new animal study suggests that the SARS-CoV-2 S1 spike protein can produce prolonged inflammation in the brain while reducing voluntary physical activity and disrupting normal daily activity patterns. Intriguingly, access to voluntary exercise appeared to prevent several persistent inflammatory changes.
SARS-CoV-2 S1 triggered prolonged brain inflammation and disrupted activity in rats, whi...
A six-week course of specially selected probiotic bacteria may substantially reduce anxiety and depressive symptoms in people struggling with post-COVID syndrome, according to a new randomized clinical trial. The findings add to growing evidence that changes in the gut may influence mental health through the gut-brain connection.
A clinical trial found that six weeks of targeted psychobiotic ...
Researchers have uncovered striking changes in the tiny blood vessels of people with post-COVID-19 syndrome, commonly called Long COVID, suggesting that vascular problems can persist long after the original infection. The abnormalities were particularly pronounced among patients who also met the criteria for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).
Long COVID patients show...
