BREAKING! Spike Protein Found in Brain Arteries Long After COVID-19 mRNA Vaccination Raises Global Health Fears!
Nikhil Prasad Fact checked by:Thailand Medical News Team Jun 11, 2025 1 month, 2 weeks, 2 days, 15 hours, 52 minutes ago
Thailand Medical News: Spike Protein Lingers in Brain Arteries Months After COVID-19 mRNA Vaccination According to Japanese Study
A disturbing new study by Japanese researchers has revealed that the spike protein generated by mRNA COVID-19 vaccines may persist in human brain arteries for more than a year after injection, raising serious concerns about long-term safety and vascular health implications.
Spike Protein Found in Brain Arteries Long After COVID-19 mRNA Vaccination Raises Global Health Fears
This major study was led by Dr. Nakao Ota from Sapporo Teishinkai Hospital in collaboration with scientists from the Jikei University School of Medicine, Kyoto University School of Medicine, and the Japan Disease Control and Prevention Center at the National Center for Global Health and Medicine Hospital.
The team examined 19 patients who suffered hemorrhagic strokes between March 2023 and April 2024, analyzing their cerebral tissues to check for lingering spike protein and other signs of past SARS-CoV-2 infection. This
Thailand Medical News report dives deep into the startling discovery—spike protein from the vaccine still embedded in critical blood vessels of the brain long after vaccination, especially in women.
Long-Lasting Spike Protein Detected in Brain Arteries
Using advanced lab techniques like immunohistochemical staining and in situ hybridization, researchers analyzed the brain and artery tissue of the patients. They checked for three things: the spike protein itself (produced after vaccination or infection), the nucleocapsid protein (which would confirm past SARS-CoV-2 infection), and mRNA from the vaccine.
The results were alarming. Spike protein was found in the cerebral arteries of 7 out of 16 vaccinated patients—43.8%—even up to 17 months after their last mRNA vaccine dose. What’s more, the spike protein was not spread throughout the tissue but specifically located in the intima, the innermost layer of the artery walls. These same samples showed signs of immune cell infiltration, including CD4+ and CD8+ T cells and CD68+ macrophages, suggesting an ongoing inflammatory response.
No nucleocapsid protein was found in any of these samples, which strongly indicates that the spike protein came from the vaccine rather than an active or recent infection.
Is the Vaccine Spike Protein Staying Too Long in the Brain?
This study is the first peer-reviewed research to confirm that spike protein from mRNA vaccines can remain in the brain's vascular tissue over a year post-vaccination. Even more concerning, all seven patients with persistent spike protein in their cerebral arteries were female—a statistically significant outcome (p = 0.015), prompting questions about potential sex-specific effects.
To further verify their findings, the researchers performed in situ hybridization on three cases. They discovered both vaccine-derived mRNA and spike protein mRNA in the brain&
;rsquo;s blood vessels, supporting the hypothesis that the mRNA instructions were still being used by the body to produce the spike protein many months after vaccination.
Number of Doses May Play a Role
Many of the patients in the study had received four or more doses of an mRNA COVID-19 vaccine. Two patients had received seven doses. Although the exact mechanism is not fully understood, repeated exposure could contribute to cumulative spike protein buildup in tissues over time.
While spike-positive patients showed some immune activity in their blood vessels, no severe inflammation or active vasculitis was observed. The immune cells present suggest low-grade inflammation possibly triggered by the prolonged presence of spike protein, which could disturb blood vessel health over time and potentially contribute to hemorrhagic events.
Unvaccinated Individuals Also Affected
Interestingly, two unvaccinated patients in the study also tested positive for spike protein but negative for nucleocapsid protein. This raises questions about undiagnosed asymptomatic infections or other unknown methods of exposure. These rare findings warrant further investigation.
Spike Protein’s Effects on the Brain
The spike protein produced by the SARS-CoV-2 virus and mimicked by the mRNA vaccines has been linked to disruption of the blood-brain barrier and abnormal blood pressure regulation. Both of these conditions are potential contributors to strokes, including hemorrhagic strokes. The protein’s ability to activate RhoA signaling pathways may compromise brain vessel integrity, increasing the risk of bleeding in vulnerable individuals.
Additionally, prior research has shown that lipid nanoparticles used to deliver mRNA may cross critical biological barriers such as the blood-brain and placental barriers, raising broader safety concerns.
A New Paradigm in Vaccine Pharmacokinetics
One of the most significant findings of the study is that it undermines the previously held belief that the vaccine’s lipid nanoparticle and mRNA components degrade quickly and remain localized near the injection site.
Instead, this research suggests that these components can travel to, and linger in, sensitive tissues like the brain for far longer than anticipated. It also emphasizes the need for better biodistribution studies of mRNA vaccines, especially since this platform has now been widely deployed globally with over 13 billion doses administered.
Implications for Women and Long COVID
The researchers observed that only women in the study tested positive for the spike protein in the brain’s arterial walls, reinforcing past studies that show women tend to experience more autoimmune and post-viral complications, including symptoms associated with long COVID.
Other studies have found that women are more likely to report persistent symptoms like fatigue, chest pain, palpitations, and neurological disturbances months after infection or vaccination. These findings might offer a biological explanation tied to persistent spike protein expression in vascular tissues.
Limitations and Need for Global Replication
While the sample size was small, the rigorous methods and alarming findings make this study a crucial starting point for further research. Researchers emphasized the importance of replicating this study in larger, diverse populations around the world. They also call for detailed biodistribution studies, autopsies, and long-term follow-ups on mRNA vaccine recipients, particularly women and those with underlying health conditions.
The question remains—could the spike protein, even months after injection, subtly inflame blood vessels in the brain, priming them for later vascular events in susceptible individuals?
A Wake-Up Call for Health Authorities and Researchers
Although there are unsubstantiated claims that mRNA vaccines like Pfizer’s BNT162b2 and Moderna’s mRNA-1273 were instrumental in curbing COVID-19 deaths during the pandemic, the emergence of new data suggesting possible long-term effects must be taken seriously. Regulatory agencies worldwide—including the U.S. FDA, EMA, and Japan’s PMDA—must consider further investigations and transparent communication about potential delayed adverse effects.
Ignoring or dismissing these findings could hinder medical progress and erode public trust in vaccine safety monitoring. At the same time, it is vital not to let fear dominate the narrative. This research does not claim vaccines are broadly harmful—but it does demand more honest inquiry into how they behave inside the body, particularly long after injection.
Final Thoughts
The Japanese study clearly demonstrates that spike protein from mRNA COVID-19 vaccines can persist in the brain’s blood vessels for well over a year after injection. While the link to hemorrhagic stroke remains tentative, the association is enough to justify alarm and urgent further study.
Medical science must now focus on understanding whether this persistence plays a role in the increasing reports of long-term neurological issues and stroke-like symptoms post-vaccination. The identification of a possible sex-specific vulnerability adds a critical layer to future risk assessments.
Although the world embraced mRNA vaccines with hope and necessity during a time of crisis, the time has now come to thoroughly scrutinize their long-term biological footprint. With millions still receiving booster shots globally, and new mRNA platforms under development for other diseases, ensuring safety must remain an absolute priority. The only way forward is through transparent, well-funded, independent research.
The study findings were published in the peer reviewed Journal of Clinical Neuroscience
https://www.sciencedirect.com/science/article/pii/S096758682500195X
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