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Source: Medical News - SARS-CoV-2 Heart Vascular Damage  Dec 23, 2021  2 years, 3 months, 3 weeks, 5 days, 5 hours, 13 minutes ago

German And Danish Scientists Using New Innovative X-Ray Imaging Shockingly Discover That SARS-CoV-2 Causes Extensive Heart Vascular Damage!

German And Danish Scientists Using New Innovative X-Ray Imaging Shockingly Discover That SARS-CoV-2 Causes Extensive Heart Vascular Damage!
Source: Medical News - SARS-CoV-2 Heart Vascular Damage  Dec 23, 2021  2 years, 3 months, 3 weeks, 5 days, 5 hours, 13 minutes ago
Scientist from the University of Göttingen-Germany, Hannover Medical School-Germany, Technical University of Denmark-Denmark and the University Medical Center of the Johannes Gutenberg University Mainz-Germany have in a new study using a new innovative x-ray imaging platform shockingly discovered that the SARS-CoV-2 coronavirus is able to cause extensive vascular damage to the heart! The study found significant changes in the heart muscle tissue of people who died from COVID-19.

Vascular network (red) in healthy heart tissue (left) and in severe COVID-19 (right). Due to faulty reforming of the network as a result of COVID-19, numerous branches, splits and even loops develop in the capillaries, which can be analyzed mathematically. Credit: M. Reichardt, P. Møller Jensen, T. Salditt

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So far damage to lung tissue has been the research focus in this area for some time and has now been thoroughly investigated but little is known about the degree of damage the SARS-CoV-2 coronavirus does to other organs, tissues and systems in the human host.
 
This is the first study that underpins the involvement of the heart in COVID-19 at the microscopic level for the first time by imaging and analyzing the affected tissue in the three dimensions.
 
The study team used a novel phase-contrast X-ray tomography to characterize the three-dimensional (3d) structure of cardiac tissue from patients who succumbed to COVID-19.
 
By extending conventional histopathological examination by a third dimension, the delicate pathological changes of the vascular system of severe Covid-19 progressions can be analyzed, fully quantified and compared to other types of viral myocarditis and controls. To this end, cardiac samples with a cross section of 3:5mm were scanned at a laboratory setup as well as at a parallel beam setup at a synchrotron radiation facility. The vascular network was segmented by a deep learning architecture suitable for 3d datasets (V-net), trained by sparse manual annotations.
 
Pathological alterations of vessels, concerning the variation of diameters and the amount of small holes, were observed, indicative of elevated occurrence of intussusceptive angiogenesis, also confirmed by high resolution cone beam X-ray tomography and scanning electron microscopy.
 
The study team implemented a fully automated