COVID-19 News: Warning For Males As SARS-CoV-2 Is Able To Cause Both Inflammation And Damage To Prostate Tissues!
: A number of studies have shown that the SARS-Cov-2 virus is able to not only cause inflammation and damage to prostate tissues but also exhibit viral persistence in these tissues for a long time!
Thailand Medical News in its COVID-19 News
coverages as early as April 2020 had already warned that the prostate gland was another target for the SARS-CoV-2 virus.
Since then, numerous other studies have emerged on this subject.
Findings from a detailed Iranian meta-analysis study to explore the potential mechanisms of SARS-CoV-2 in targeting the prostate gland, leading to exacerbation of benign prostatic hyperplasia (BPH) symptoms and greater risks of BPH complications such as acute urinary retention was published in May 2021.
The meta-analysis study involving 52 peer-reviewed published papers revealed that a hyperactivated RAS system during infection with SARS-CoV-2 leads to activation of pro-inflammatory pathways and increased cytokine release. Hence it was found that infections with the SARS-CoV-2 virus can lead to exacerbation of lower urinary tract symptoms (LUTS) and trigger inflammatory processes in the prostate gland. Since androgen receptors (AR) play an important role in the BPH pathophysiology and infection with SARS-CoV-2 may be androgen-mediated, BPH progression and its related symptoms can be a complication of COVID-19 through AR involvement and metabolic disturbances.
A Saudi Arabian study published in November 2020 provided the first pathological evidence of SARS-CoV-2 infections causing inflammation in prostate tissues. Mild mononuclear inflammatory cell infiltration was the most frequent histologic finding in general besides organ-specific changes. Microthrombi were also in noticed in the prostates besides other tissue damages.
An immunohistochemical and ultrastructural study and case report by researchers from the Department of Urology, Miller School of Medicine, University of Miami-USA in April 2022, revealed that SARS-CoV-2 has both the ability to enter prostatic tissue during an acute infection and persist over a timeframe beyond the initial infection period as RNA-containing viral bodies.
The study findings and case report provide preliminary evidence that SARS-CoV-2 not only enters prostatic tissue during an acute infection but may persist beyond the initial infection period. TMPRSS2 and ACE2 are found in relatively high concentrations in prostatic tissue, making the prostate a potential target for SARS-CoV-2 invasion.
Using EM, the study team found that the patient had residual viral particles in his prost
atic tissue four months after prostate enucleation for benign prostatic hyperplasia. In tandem with existing research noting viral absence in sperm, further investigation into the replicative potential of these prostatic viral bodies is needed.
That case report lays the foundation for future investigations to examine any histopathologic changes to the prostatic tissue that may be associated with SARS-CoV-2 infection. It also brings forth the importance of investigating mental health burden and its impact on existing disease state outcomes.
Beyond establishing the persistence of SARS-CoV-2 particles in prostatic tissue, the study findings suggest the importance of discerning the relationships between COVID-19, lower urinary tract symptom severity, and prostatic hyperplasia.
While there other studies that show SARS-CoV-2 infections can also aggravate existing prostate issues, these studies listed here shows that the virus causes inflammation and damage to prostate tissues in other healthy males.
It is important that all Post COVID males undergo frequent health screenings with a focus on the prostate gland as well.
For the latest COVID-19 News
, keep on logging to Thailand Medical News.