Kittisak Meepoon Fact checked by:Thailand Medical News Team Dec 04, 2025 59 minutes ago
Medical News: Brain Aging Might Not Be Permanent After All
A groundbreaking study from researchers at the Boston University Chobanian & Avedisian School of Medicine has found that the aging brain may be far more capable of repair than once believed. Using a special treatment derived from stem cells in bone marrow, scientists have demonstrated a way to slow down and even reverse memory loss associated with aging.
New research shows stem cell vesicles can reverse age-related memory loss in the brain
The treatment uses tiny natural particles called extracellular vesicles or EVs. These vesicles, which carry vital proteins, RNAs, and lipids, are released by mesenchymal stem cells and can help reduce inflammation and improve brain cell function. In a two-year study on middle-aged rhesus monkeys, scientists saw improved memory and stronger communication between brain regions after the animals were given EV infusions from young, healthy donor cells.
This
Medical News report highlights how aging brains responded positively to these bi-weekly treatments. The animals receiving EVs performed better on memory and learning tests and showed better brain connectivity in MRI scans compared to untreated monkeys.
Targeting White Matter Damage to Restore Brain Function
One of the most surprising findings was that the therapy protected the white matter in the brain. White matter acts like the brain's wiring system, linking various areas so they can communicate effectively. Aging usually causes white matter to deteriorate, but in treated monkeys, this damage slowed or even reversed. This may explain the improvements seen in memory tests and the reduction in perseverative behaviors—where individuals repeat tasks even when no longer rewarded, a common sign of cognitive aging.
Lead researcher Evan Mackie, a PhD candidate in anatomy and neurobiology, explained, “We found that the aging brain retains a remarkable capacity for resilience.” Senior author Dr. Tara Moore added that this technique could one day benefit not just aging but also conditions like Alzheimer’s disease, stroke, and multiple sclerosis.
A New Frontier in Anti-Aging Medicine
This treatment may mark a shift in how scientists think about cognitive aging. Until now, many believed the brain’s decline in memory and thinking was inevitable. However, by preserving the brain’s wiring and reducing harmful inflammation, this cell-based therapy gives new hope for maintaining brain health even in later years.
The researchers caution that more work is needed, particularly in older animals and human trials. But this study opens the door to potentially safe and non-invasive treatments that could promote healthy aging.
The study findings were published in the peer reviewed journal: Geroscience.
https://link.springer.com/article/10.1007/s11357-025-01992-0
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Read Also:
https://www.thailandmedical.news/articles/anti-aging
https://www.thailandmedical.news/articles/stem-cell-therapies
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