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COVID-19 News - Class Switch To IgG4 Antibodies  Jan 31, 2023  1 year, 3 weeks, 6 days, 16 hours, 31 minutes ago

COVID-19 News: Study Shows mRNA Shots Cause Class Switch Toward Noninflammatory, Spike IgG4 Antibodies Which Causes Dysfunctional Immunity!

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COVID-19 News: Study Shows mRNA Shots Cause Class Switch Toward Noninflammatory, Spike IgG4 Antibodies Which Causes Dysfunctional Immunity!
COVID-19 News - Class Switch To IgG4 Antibodies  Jan 31, 2023  1 year, 3 weeks, 6 days, 16 hours, 31 minutes ago
COVID-19 News: A new study conducted by German researchers have shown that repeated doses of the mRNA shot can cause a class switch towards noninflammatory, spike-specific IgG4 antibodies which can damage both the innate and adaptive immunity and create a condition of dysfunctional immunity! This can also pave the way for enhanced viral persistence!


 
The study team comprised of scientists from Universitätsklinikum Erlangen und Friedrich-Alexander-Universität (FAU)-Germany, University of Luebeck-Germany and the University of Freiburg-Germany.
 
The mRNA shots are claimed to be efficient preventive measures to combat the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic.
 
Importantly, high levels of neutralizing SARS-CoV-2 antibodies are an important component of vaccine-induced immunity.
 
It was found that shortly after the initial two mRNA vaccine doses, the immunoglobulin G (IgG) response mainly consists of the proinflammatory subclasses IgG1 and IgG3.
 
The study team reported that it was found that several months after the second vaccination, SARS-CoV-2–specific antibodies were increasingly composed of noninflammatory IgG4, which were further boosted by a third mRNA vaccination and/or SARS-CoV-2 variant breakthrough infections.
 
IgG4 antibodies among all spike-specific IgG antibodies rose, on average, from 0.04% shortly after the second vaccination to 19.27% late after the third vaccination. This induction of IgG4 antibodies was not observed after homologous or heterologous SARS-CoV-2 vaccination with adenoviral vectors.
 
Interestingly, single-cell sequencing and flow cytometry revealed substantial frequencies of IgG4-switched B cells within the spike-binding memory B cell population [median of 14.4%; interquartile range (IQR) of 6.7 to 18.1%] compared with the overall memory B cell repertoire (median of 1.3%; IQR of 0.9 to 2.2%) after three immunizations.
 
Importantly, this class switch was associated with a reduced capacity of the spike-specific antibodies to mediate antibody-dependent cellular phagocytosis and complement deposition. Because Fc-mediated effector functions are critical for antiviral immunity, these study findings may have consequences for the choice and timing of vaccination regimens using mRNA vaccines, including future booster immunizations against SARS-CoV-2.
 
The study findings were published in the peer reviewed journal: Science Immunology.
https://www.science.org/doi/10.1126/sciimmunol.ade2798
 
The four human IgG subclasses have distinct effector properties due to differences in binding Fc receptors and activating complement.
 
Typically, the serum concentration of human IgG4 is normally lower than either IgG1, IgG2, or IgG3. It was found that anti-spike IgG4 as a fraction of total anti-spike IgG rose by 6 months after the second vaccination and increased further after a third vaccine dose. Serum antibody effector activity assessed by antibody-dependent phagocytosis or complement deposition was less after the third dose than after the second dose.
 
In simple layman’s terms, it means that that for people who have received a couple of the mRNA shots , their immune system has now changed and considers that the virus should not be neutralized at all!
 
Typically, when the human body is repeatedly exposed to harmless foreign bodies such as pollen, beneficial microbiota etc, dendritic cells make a ‘decision’, and they begin producing IgG4 antibodies. These function as effective ‘lay-off’ signals ie upon encountering the foreign body, the IgG4antibody binds to it, any immune cell it encounters will be instructed to not neutralize or damage it!
 
When this happens to the SARS-CoV-2 virus, viral persistence is enhanced and low levels of inflammation and gradual damage by the virus can lead to a whole spectrum of worrisome health issues including organ failure and death due to cell damage and dysfunction! We have already covered in our various COVID-19 News coverages about the issue of SARS-CoV-2 viral persistence.
 
https://www.thailandmedical.news/news/long-covid-news-australian-study-shows-that-immune-dysfunction-persists-for-up-to-8-months-after-initial-mild-or-moderate-sars-cov-2-infection
 
https://www.thailandmedical.news/news/breaking-covid-19-news-finally,-u-s-nih-warns-sars-cov-2-viral-persistence-is-a-serious-issue-that-is-also-affecting-long-covid
 
https://www.thailandmedical.news/news/covid-news-new-york-scientists-find-sars-cov-2-viral-presence-in-the-lung-up-to-359-days-after-acute-phase-of-disease-even-in-the-negative-tested
 
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https://www.thailandmedical.news/news/breaking-latest-u-s-nih-study-reveals-viral-persistence-is-a-major-issue-and-that-sars-cov-2-replicates-in-tissues-for-months-in-post-covid-individua
 
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The IgG4 antibodies act to suppress the innate immune system as well as the adaptive: they bind to FcγRIIB complexes on cell surfaces that variously deactivate and destroy immune responses and cells, they bind to the virions themselves, they bind to CD4 T-cells and dendritic cells, and they even bind to the signal cascade transducers of the complement immune system!
 
With the complete shutdown of the complement system, the human host is very vulnerable the net time they are exposed to new SARS-CoV-2 variants!
 
The IgG4 class switch represents a complete shift towards deactivation of the entire response upon detection of SARS-CoV-2 antigens, affecting almost every step in the cascades. There are multiple means by which the cascades may begin.
 
For readers to want to understand more about the implications of the class switch to IgG4 caused by the mRNA shots, we strongly reading the detailed explanation by independent researcher Adam Gaertner.
https://veryvirology.substack.com/p/igg4-antibody-class-switch-end-of
 
For readers who wish to know what the spike proteins can do to the human host during viral persistence, we suggest reading articles by yet another esteemed independent researcher, Walter M Chestnut
https://wmcresearch.substack.com/
 
For the latest COVID-19 News, keep on logging to Thailand Medical News.
 

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