BREAKING NEWS
Source: Latest Omicron News  Dec 19, 2021  6 months ago
BREAKING! The Omicron Sub-Lineage Temporarily Called England/MILK-2D24AC9/2021 That Is Spreading In UK Is Vastly Different From The South African Omicron!
BREAKING! The Omicron Sub-Lineage Temporarily Called England/MILK-2D24AC9/2021 That Is Spreading In UK Is Vastly Different From The South African Omicron!
Source: Latest Omicron News  Dec 19, 2021  6 months ago
Latest Omicron News: As the United Kingdom is preparing to go into a major lockdown as early as next week just after Christmas unless things even worsen, scientists are already scrambling to uncover why there is a vast difference in what had happened in South Africa with regards to the Omicron and the way things are spiraling out of control in the United Kingdom with hospitals now being over run with daily new cases of COVID-19 infections.


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Unknown to many, the United Kingdom has its own Omicron sub-lineage that is temporarily named as 
https://github.com/cov-lineages/pango-designation/issues/367

This new UK Omicron sub-lineage is different in many aspects from that found in South Africa!
 
Thailand Medical News has been warning about this for nearly 2 weeks but we did not have the time to write this article.
 
The Omicron variant or B.1.1.529 had earlier this month split into two sub-lineages BA.1 and BA.2. These two variants have some shared mutations, besides some mutations that are unique to them. https://www.thailandmedical.news/news/breaking-scientists-discover-that-two-forms-of-omicron-ba-1-and-the-new-ba-2-which-is-a-stealth-version-that-cannot-be-detected-by-pcr-tests

However alarmingly, a new Omicron sub-lineage had emerged in the UK in the first few days of December based on genomic sequencings and it is this new Omicron lineage that is spreading around rapidly. This new diverse genome has appeared within the Omicron B.1.1.529 lineage and has all of the shared mutations of B.1.1.529, some of the mutations unique to BA.1 and some unique to BA.2 plus a few of its own.

It is vastly different from the other two Omicron sub-lineages in term of characteristics, properties and pathogenesis and stupid experts, ignorant scientists and garbage media should stop making reference to studies with regards to disease severity, immune evasiveness, vaccine efficacy based on the Omicron variant that was found in South Africa and comparing it to what is happening in UK and soon elsewhere around the world.
 
As Thailand Medical News had warned in its Latest Omicron News segment that as SARS-CoV-2 variants move around in different geolocations, race and local population genetics plays a role in giving rise to new mutations especially in the ORF10 region, resulting in unique variants.
veals-various-orf10-protein-mutations-in-different-countries-and-regions-that-specify-different-sars-cov-2-pathogenicity-modes">https://www.thailandmedical.news/news/breaking-study-reveals-various-orf10-protein-mutations-in-different-countries-and-regions-that-specify-different-sars-cov-2-pathogenicity-modes
 
This new UK Omicron sub-lineage uniquely contains the mutations C832T and T223V plus further more changes have been observed in the ORF10 region. A latest update not listed in the github site shows that it also spots the R346K mutation in the RBD.
 
The conformational structure of the new UK Omicron variant is also very different with preliminary studies showing that it is much more evolved for antibody escape and easier binding to human host receptors (Not just ACE2 alone!).
 
As of the last two hours, we are also receiving unpublished data that there are also another 3 more new Omicron sub-lineages detected in the U.S., Germany and Denmark with unique mutations on them as well, we will be covering on those later but the key thing that should be noted is that the Omicron variant as a whole is still evolving and rather aggressively.
 
Reverting back to the U.K. Omicron sub-lineage, everyone should stop making assumptions about Omicron as a whole being mild or that even booster shots can provide protection until specific studies are carried out with the specific Omicron sub-lineage being tested and listed in the studies. We are no longer dealing with one type of Omicron variant for gawds sake!
 
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For the Latest Omicron News, keep on logging to Thailand Medical News.

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