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Nikhil Prasad  Fact checked by:Thailand Medical News Team Dec 19, 2023  2 months, 2 days, 7 hours, 19 minutes ago

COVID-19 News: Scientists Warn That Existing mRNA COVID-19 ‘Prophylactics’ Create Environment For Neoplastic Transformation Leading To Various Cancers!

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COVID-19 News: Scientists Warn That Existing mRNA COVID-19 ‘Prophylactics’ Create Environment For Neoplastic Transformation Leading To Various Cancers!
Nikhil Prasad  Fact checked by:Thailand Medical News Team Dec 19, 2023  2 months, 2 days, 7 hours, 19 minutes ago
COVID-19 News: The global response to the COVID-19 pandemic has witnessed unprecedented efforts in vaccine development, with mRNA vaccines emerging as frontrunners. While these vaccines have played a crucial role in curbing the spread of the virus and preventing severe illness, recent scientific discussions have raised concerns about potential long-term health implications, particularly in relation to cancer. This COVID-19 News report delves into the intricate molecular pathways and mechanisms that scientists suggest may contribute to neoplastic transformation, shedding light on the need for in-depth investigations and long-term monitoring.


The Spike Glycoprotein's Role in Cell Signaling and Tumorigenesis
The SARS-CoV-2 spike glycoprotein, comprised of S1 and S2 subunits, is a key player in the virus's entry into human cells. While its primary function is to facilitate binding to ACE2 receptors, recent studies suggest that the S1 subunit may activate MEK, a critical component of the ERK signaling pathway associated with cell growth. Additionally, the full-length spike downregulates ACE2, triggering AT1R-mediated signaling, NF-κB activation, and an increase in IL-6 levels. These molecular events potentially create conditions favorable to cancer progression.
NF-κB activation, known for promoting cancer cell proliferation, chemoresistance, and invasion, raises concerns about the potential role of the spike protein in oncogenic processes. Similarly, the Ras/Raf/MEK/ERK (MAPK) signaling cascade, implicated in over 30% of human cancers, becomes a potential driver of malignancy in the context of COVID-19 infection. Elevated IL-6 levels, correlating with increased tumor relapse in various cancers, add another layer of complexity.
The AT1R-mediated signaling cascade, activating PI3K, a master regulator for cancer, suggests a direct link between spike-mediated cell signaling and cancer progression. The persistent presence of spike fragments in the body following vaccination raises questions about potential long-term consequences that warrant thorough investigation.
mRNA Vaccines and Toll-like Receptor (TLR) Mediated Immune Responses
mRNA vaccines, designed to deactivate the host's innate immunity, utilize Toll-like receptors (TLRs) in the immune response. TLRs play a crucial role in recognizing pathogens and triggering immune responses. However, mRNA vaccines incorporate modified nucleosides to prevent excessive immune activation, as uncontrolled responses can lead to adverse reactions.
Studies show that COVID-19 mRNA vaccines significantly decrease the production of type I interferons (IFNs) following TLR activation. Type I IFNs are vital for antiviral immune responses, and their reduction may impact the ability to clear viral infections. Defects in TLR expression are associated with herpesvirus infections, and an increased number of herpes zoster cases have been reported following mRNA vaccination, suggesting a potential link between vaccine-induced TLR m odulation and immune dysfunction.
The delicate balance between immune activation and suppression becomes a critical factor in vaccine safety. The reduction in type I IFNs, essential for antiviral responses, raises questions about the broader implications for immune function and the potential for increased susceptibility to viral infections. As TLRs play a crucial role in recognizing and responding to pathogens, their modulation by mRNA vaccines adds complexity to the overall understanding of the vaccine's impact on the immune system.
Codon Optimization and the RNA-G Quadruplex (G4)-Protein Binding System
Codon optimization, a gene engineering approach used in COVID-19 vaccines, involves synonymous codon changes to enhance protein production. However, increased GC content resulting from codon optimization may lead to the dysregulation of the RNA-G quadruplex (G4)-protein binding system. In silico analyses suggest that codon-optimized mRNA vaccines exhibit an increased number of G4 motifs, potentially impacting the translational regulation of cellular microRNAs.
Dysregulation of the RNA-G quadruplex-protein binding system may downregulate cellular microRNA expression, influencing various pathological conditions, including cardiovascular disease, neurodegeneration, and cancer progression. The complex interplay between codon optimization, G4 formation, and microRNA regulation underscores the need for comprehensive studies to evaluate the safety and efficacy of such optimizations in human therapeutics.
The potential impact of codon optimization on cellular processes and regulatory mechanisms raises questions about unintended consequences. The intricate dance between G4 motifs and microRNA expression has broader implications for cellular homeostasis, and any dysregulation could contribute to pathological conditions, including cancer. Understanding the long-term effects of codon optimization becomes crucial for ensuring the safety and efficacy of mRNA-based vaccines.
Lipid Nanoparticles (LNPs) and Inflammatory Responses
Lipid nanoparticles (LNPs) are integral components of mRNA-based COVID-19 vaccines, enhancing mRNA stability and delivery. Recent findings reveal that cationic LNPs used in preclinical studies induce inflammatory responses in mice, with implications for vaccine safety.
While LNPs contribute to the efficacy of mRNA vaccines, their inflammatory properties may lead to uncontrolled activation of various inflammatory pathways. Understanding the interactions between cationic LNPs and intracellular pattern recognition receptors is crucial for assessing potential inflammatory signatures and cytotoxicity. The association between inflammation and cancer development underscores the importance of investigating the impact of LNPs on long-term health outcomes.
The role of LNPs in triggering inflammatory responses adds another layer to the safety considerations of mRNA vaccines. The delicate balance between the need for an effective immune response and the risk of inflammatory side effects becomes a critical factor in assessing the overall safety profile of these vaccines. Investigating the long-term consequences of LNP-induced inflammation is essential for a comprehensive understanding of the potential risks associated with mRNA vaccination.
Potential Reverse-Transcription and Genomic Integration
A study suggests the possibility of reverse-transcription and genomic integration of foreign RNA, such as SARS-CoV-2 sequences, within infected cells. This phenomenon, observed in vitro, raises concerns about potential genomic instability and insertional mutagenesis.
The activation of LINE-1, an endogenous retrotransposon, following BNT162b2 mRNA entry into cells adds another layer of complexity. LINE-1 activation may increase the risk of insertional mutagenesis, disrupting coding regions and potentially leading to DNA damage. The implications of these findings for long-term genomic stability and the risk of cancer development require further exploration.
The possibility of foreign RNA integration into the host genome presents a unique challenge in understanding the long-term consequences of mRNA vaccination. Genomic instability and insertional mutagenesis are well-established factors in cancer development, and any potential association with mRNA vaccines raises critical questions about their safety. Comprehensive studies are needed to elucidate the mechanisms and assess the risk-benefit balance of mRNA vaccination in the context of genomic stability.
S2 Subunit Interaction with Tumor Suppressor Proteins
In silico analyses propose a strong interaction between the S2 subunit of the spike glycoprotein and tumor suppressor proteins p53 and BRCA1/2. Tumor suppressor proteins play crucial roles in maintaining cellular homeostasis and genome integrity, and their dysregulation is associated with cancer development.
If the S2 subunit indeed interacts with tumor suppressor proteins in vivo, this interaction may have implications for cancer cell survival, invasion, metastasis, and chemoresistance. Understanding the potential impact of such interactions on both cycling and non-cycling cells, including neurons, is vital for assessing the long-term consequences of COVID-19 infection and vaccination.
The proposed interaction between the S2 subunit and tumor suppressor proteins adds a new dimension to the potential oncogenic implications of COVID-19 infection and vaccination. Tumor suppressor proteins are guardians of genomic integrity, and any disruption in their function may contribute to the initiation and progression of cancer. Investigating the in vivo relevance and consequences of the S2 subunit's interaction with tumor suppressors becomes imperative for a comprehensive understanding of the potential risks associated with COVID-19 vaccination.
CD147 Transmembrane Protein and Cancer Correlation
Recent research proposes CD147 as a novel entry route for SARS-CoV-2, potentially contributing to virus infection. CD147, previously correlated with various cancers, may act as a complementary receptor, activating tumorigenic pathways and promoting cancer progression.
The proposed interaction between the spike glycoprotein and CD147 raises concerns about its potential contribution to cancer development and recurrence. Further studies are needed to elucidate the molecular mechanisms and biological consequences of this interaction in the context of oncogenesis.
The identification of CD147 as a potential entry route for SARS-CoV-2 adds complexity to the understanding of the virus's interaction with host cells. The correlation of CD147 with various cancers underscores the need for in-depth investigations into the potential oncogenic implications of its interaction with the spike glycoprotein. Unraveling the intricacies of this relationship is essential for assessing the broader impact of COVID-19 infection and vaccination on cancer risk.
In conclusion, the potential oncogenic implications of COVID-19 mRNA vaccines warrant thorough investigation and ongoing monitoring. The intricate molecular pathways and interactions highlighted in this comprehensive review underscore the need for a multidisciplinary approach to comprehensively assess the long-term safety and efficacy of mRNA-based vaccines. As the global community continues to combat the COVID-19 pandemic, scientific rigor and transparency remain essential to ensure the health and well-being of populations worldwide. Rigorous research, ongoing surveillance, and transparent communication will be paramount in addressing emerging concerns and ensuring the continued success of vaccination efforts.
The study review was published in the peer reviewed journal: Cureus.!/
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