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Source: Medical News-Immunodeficient  Nov 20, 2021  2 years, 3 months, 1 day, 20 hours ago

Why Is No One Warning The Masses That The SARS-CoV-2 Spike Proteins Are Causing Major Immunodeficiency Issues In All Infected Individuals?

Why Is No One Warning The Masses That The SARS-CoV-2 Spike Proteins Are Causing Major Immunodeficiency Issues In All Infected Individuals?
Source: Medical News-Immunodeficient  Nov 20, 2021  2 years, 3 months, 1 day, 20 hours ago
Since the COVID-19 pandemic first broke in Wuhan China in late November 2019 and two years down the road, there has been more than 140 odd published studies in peer reviewed journals that shows that the spike proteins of the SARS-CoV-2 coronavirus causes a major disruption and dysregulation of the human host immune system irrespective of whether the individuals were asymptomatic or had mild, moderate or even severe disease conditions. Months and years after recovery, we are finding that the immune system of those that are deemed recovered are still displaying dysregulated immune systems making them susceptible to secondary infections, reinfections to various emerging variants of the same SARS-CoV-2 virus and also susceptible to existing dormant viruses in their bodies or even to oncogenic proteins.

The spike proteins whether through infections or other means are causing a decrease of CD8 T cells and in some cases even dysregulated or deformed CD8 T Cells.,-altering-or-even-destroying-cd8-cells-new-australian-study-suspects-so">!-covid-19-immunology-study-shows-high-levels-of-t-cells-with-significantly-altered-function-and-phenotype-in-severe-covid-19-patients
CD8-positive T cells are a critical subpopulation of MHC class I-restricted T cell and are mediators of adaptive immunity. They include cytotoxic T cells, which are important for killing cancerous or virally infected cells, and CD8-positive suppressor T cells, which restrain certain types of immune response.
CD8+ (cytotoxic) T cells, like CD4+ Helper T cells, are generated in the thymus and express the T-cell receptor. However, rather than the CD4 molecule, cytotoxic T cells express a dimeric co-receptor, CD8, usually composed of one CD8α and one CD8β chain. CD8+ T cells recognize peptides presented by MHC Class I molecules, found on all nucleated cells. The CD8 heterodimer binds to a conserved portion (the α3 region) of MHC Class I during T cell/antigen presenting cell interactions.
CD8+ T cells (often called cytotoxic T lymphocytes, or CTLs) are very important for immune defense against intracellular pathogens, including viruses and bacteria, and for tumor surveillance. When a CD8+ T cell recognizes its antigen and becomes activated, it has three major mechanisms to kill infected or malignant cells. The first is secretion of cytokines, primarily TNF-α and IFN-γ, which have anti-tumor and anti-viral microbial effects.
The second major function is the production and release of cytotoxic granules. These granules, also found in NK cells, contain two families of proteins, perforin, and granzymes. Perforin forms a pore in the membrane of the target cell, similar to the membrane attack complex of complement. This pore allows the granzymes also contained in the cytotoxic granules to enter the infected or malignant cell. Granzymes are serine proteases which cleave the proteins inside the cell, shutting down the production of viral proteins and ultimately resulting in apoptosis of the target cell.
The cytotoxic granules are released only in the direction of the target cell, aligned along the immune synapse, to avoid non-specific bystander damage to healthy surrounding tissue. CD8+ T cells are able to release their granules, kill an infected cell, then move to a new target and kill again, often referred to as serial killing.
The third major function of CD8+ T cell destruction of infected cells is via Fas/FasL interactions. Activated CD8+ T cells express FasL on the cell surface, which binds to its receptor, Fas, on the surface of the target cell. This binding causes the Fas molecules on the surface of the target cell to trimerise, which pulls together signalling molecules. These signalling molecules result in the activation of the caspase cascade, which also results in apoptosis of the target cell. Because CD8+ T cells can express both molecules, Fas/FasL interactions are a mechanism by which CD8+ T cells can kill each other, called fratricide, to eliminate immune effector cells during the contraction phase at the end of an immune response.
The decrease of dysregulation of CD8 T cells or in many cases the manifestations of ‘exhausted’ CD8 T cells as a result of SARS-CoV-2 infections even months after so called recovery is concerning.
Besides the CD8 T Cells, we also have other components of the immune system being infected for example the CD19 cells are down regulated.
There are other persistent leukocytes changes even months after recovery.
Various dendritic cells are reduced or functional competence compromised as a result of SARS-CoV-2 infection.
The SARS-CoV-2 spike proteins causes immune dysregulation in so many other ways.,-the-sars-cov-2-manipulates-human-host-immune-system-to-facilitate-its-long-term-stay,-this-time-by-using-its-orf6-protein-to-hijack-the-nup98-pathway,-infects-monocytes,-macrophages-and-can-cause-fibrosis-in-post-covid-19,-sars-cov-2-does-not-trigger-a-strong-immune-reaction-rather-it-causes-dysfunctional-immune-issues
These are just some of the more than 140 peer reviewed studies that can be found in Thailand Medical News along with another 67 preprint studies that shows how the SARS-CoV-2 virus and its spike proteins disrupt and dysregulate the human host immune system.
The implications of all these studies are worrying as it means that the world is facing a major health crisis that is even worst that HIV considering that the SARS-CoV-2 virus is airborne and even more transmissible than HIV.
An immunodeficient system means that many of these who had been infected with the SARS-CoV-2 virus are more susceptible to secondary infections be it virus, bacteria or fungi based, more prone to reinfections by the emerging SARS-CoV-2 variants (a process known as viral priming) and also more susceptible to activation of dormant pathogens such as herpes, TB, etc and also more susceptible to cancer causing proteins or genes.
Already there are studies that confirm that SARS-CoV-2 are making people more susceptible to Herpes reactivation, Guillain-Barre reactivation, candida auris infection etc.,-disrupting-immune-system-and-giving-rise-to-dangerous-opportunistic-infections-including-candida-auris
Many other kinds of opportunistic fungal infections are also occurring in those that were infected. with SARS-CoV-2 due to an impaired immune condition.
Many of these so called recovered COVID-19 patients are basically vulnerable to various bacterial and viral infections.
In fact, it is even anticipated that this coming flu season will be more catastrophic as there are millions out there with an impaired immune system.,-warning-for-coming-flu-season
In terms of various health conditions arising due to Long COVID, the dysregulation in the immune system can be causing some of these conditions as well.
A past study has shown that the common condition of fatigue in long COVID-19 could be due to changes in CD4 and CD8 immune cells.
With HIV one loses the helper T cells or CD4 cells. In this current pandemic, what we’re seeing is a drop in the killer T cells or CD8 cells. These CD8 cells keep all other viruses in check.
Doctors around the world are reporting an uptick in the herpes family of viruses, as well as shingles, mono and human papillomavirus (HPV) in the cervical biopsies and pap smears of women, and tissue biopsies of men.
A proper immune system in the body to keep cancer in check. Physicians are reporting that endometrial cancers, invasive melanomas and various other cancers are fast increasing in recent months.
Already it is projected that the incidence of various cancers will be high this year.
Furthermore, many secondary opportunistic infections that are often seen in HIV patients are also manifesting in those that were infected with SARS-CoV-2 such as such as molluscum contagiosum due to a compromised immune condition.
Basically, millions of people out there are walking around with a weakened immune system. And are not even aware of it!
Physicians, medical experts and authorities and governments are not warning the masses of these phenomena and the need for proper health and immune screenings and relevant therapeutic treatments and also warnings of what to do or not do.
SARS-CoV-2 is not just a respiratory disease, it causes an immunodeficient condition in all who have been infected with the virus.
(Note: This is a merely a quick rough paper written by Nikhil Prasad from Thailand Medical News in the last 15 minutes. A detailed paper will be made available in December for publication in a leading journal.)


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