Source: Thailand Medical News Dec 26, 2019 4 years ago
Pharma Industry News
Roche and Sarepta have signed a legal deal providing Roche exclusive commercial rights to SRP-9001 (AAVrh74.MHCK7.micro-dystrophin), Sarepta’s investigational gene therapy for Duchenne muscular dystrophy (DMD), outside the United States.
Under the terms of the deal, Sarepta will receive US$1.15 billion in an upfront payment and an equity investment; up to $1.7 billion ...
Source: Thailand Medical News Dec 26, 2019 4 years ago
Medical researchers at the University of Toronto have discovered how a brief disruption to a molecular pathway in the guts of animal models before they are born can compromise adult immunity to a common and often deadly intestinal virus.
The study team found that in utero inhibition of molecular signaling in the ‘lymphotoxin pathway,’ long known as important in the development of th...
Source: Thailand Medical News Dec 26, 2019 4 years ago
In a new review article published in the Dec. 26 issue of The New England Journal of Medicine, Johns Hopkins Medicine neuroscientist Dr Mark Mattson, Ph.D., concludes that intermittent fasting and time restricted eating not only has many medical and health merits but should be adopted regimen of a healthy lifestyle.
Dr Mattson, who has studied the health impact of intermittent fa...
Source: Thailand Medical News Dec 25, 2019 4 years ago
It was reported that a skin-lightening cream from Mexico that contained toxic mercury left a California woman with significant central nervous system damage, doctors report in a case study. Whats more alarming is that after the report, more media outlets are reporting that similar creams that are being made in China are finding its way all around the world from South-East Asia, India, Japan, Austr...
Source: Thailand Medical News Dec 25, 2019 4 years ago
The Staph (Staphylococcus) bacteria, is the leading cause of potentially dangerous skin infections, are most feared for the drug-resistant strains that have become a serious threat to public health. Attempts to develop a vaccine against methicillin-resistant Staphylococcus aureus (MRSA) have failed to outsmart the superbug's ubiquity and adaptability to antibiotics.
However a new ...
Source: Thailand Medical News Dec 25, 2019 4 years ago
According to a review published in JAMA Oncology Journal, the use of acupuncture and/or acupressure is associated with reduced cancer pain and decreased use of analgesics
Dr Yihan He, Ph.D., from the Second Affiliated Hospital of Guangzhou University of Chinese Medicine in China, and colleagues conducted a systematic literature review to identify randomized clinical trials (RCTs)...
Source : Thailand Medical News Dec 25, 2019 4 years ago
Most individuals under 60 who develop gastric or stomach cancer have a "genetically and clinically distinct" disease, new Mayo Clinic research has discovered. Compared to stomach cancer in older adults, this new, early onset form often grows and spreads more quickly, has a worse prognosis, and is more resistant to traditional chemotherapy treatments, the study finds. The research was pub...
Source : Thailand Medical News Dec 25, 2019 4 years ago
Researchers from Nanyang Technological University (NTU), Singapore have found an easier way to harvest healing factors ie molecules that promote tissue growth and regeneration, from adult stem cells.
Currently, scientists 'pre-condition' adult stem cells to secrete healing factors by putting them in a low-oxygen chamber or by using biochemicals or genetic engineering.
The NTU ...
Source: Thailand Medical News Dec 25, 2019 4 years ago
According to a new pilot study, a diet low in fat and high in egg whites could be the key to boosting male fertility
The new research, by Dr. Karma Pearce from the University of South Australia in collaboration with fertility specialist Prof Dr Kelton Tremellen, Repromed, and Flinders University, presents a direct link between diet and testosterone, showing that what men eat could affect the...
Source: Thailand Medical News Dec 24, 2019 4 years ago
Onco-genetic investigators from the Brigham And Women’s Hospital by leveraging advancements in nanotechnology, have found that restoring p53 not only delays the growth of p53-deficient liver and lung cancer cells but may also make tumors more vulnerable to cancer drugs known as mTOR inhibitors.
p53
In recent preclinical experiments, investigators restored p53 using synthetic mRNA nanopart...
Source: Thailand Medical News Dec 24, 2019 4 years ago
At the moment, from a statistic perspective, Alzheimer's affects one-in-ten adults over the age of 65 a number that is expected to triple by 2030. The need to find a cure is extremely critical.
There might be a glimmer of hope now. A research team headed by Dr Hervé Bercovier, Dr Charles Greenblatt and Dr Benjamin Klein at the Hebrew University of Jerusalem (HU)'s Department of M...
Source: Thailand Medical News Dec 24, 2019 4 years ago
Though immune checkpoint inhibitors are important medications that boost the immune system's response against certain cancer, they tend to be ineffective against glioblastoma, the most deadly primary brain tumor in adults. New research in animal models led by investigators at Massachusetts General Hospital (MGH) and the University of Florida reveals a promising strategy that makes glioblastoma...
Source: Thailand Medical News Dec 24, 2019 4 years ago
Medical researchers at Karolinska Institutet in Sweden have deciphered the diabetogenic role of a certain type of calcium channel in insulin-secreting beta cells. The researchers believe that blockade of these channels could be a potential new treatment strategy for diabetes.
The recent study is published in the scientific journal PNAS.
The CaV3.1 channels have a marginal role in healthy ...
Source: Thailand Medical News Dec 24, 2019 4 years ago
A simple and common cardiac blood test done before surgery can predict who will experience adverse outcomes after most types of surgery, says an international study led by Hamilton Health Sciences, Ontario researchers.
Worldwide, of the 280 million adults who undergo major surgery, 18 percent will experience serious cardiac and vascular complications including death within 30 day...
Source: Thailand Medical News Dec 24, 2019 4 years ago
Medical researchers from Icahn School Of Medicine, Mount Sinai say a new hair growth discovery might help men keep their locks for a lifetime. The new insight involves a structure lying within the hair follicle.
Lead researcher Dr. Michael Rendl, an associate director of the Black Family Stem Cell Institute at the Icahn School of Medicine at Mount Sinai, in New York City told Thailand Medi...
Source: Thailand Medical News Dec 24, 2019 4 years ago
Genomic and medical researchers at The University of Western Australia, Harry Perkins Institute of Medical Research and Curtin University have made a fundamental discovery about of the regulation of genes in mitochondria, providing a new insight into potential drug targets for diseases that involve energy loss.
The new research, published in Science Advances, was led by UWA's Professor...
Source: Thailand Medical News Dec 24, 2019 4 years ago
New research involving detailed data analysis based on data from the America’s Women's Health Initiative found a potential inverse association between dietary magnesium and fatal coronary heart disease in postmenopausal women. The study, which also showed a trend between magnesium and sudden cardiac death in this population, is published in Journal of Women's Health.
Dr Charl...
Source: Thailand Medical News Dec 23, 2019 4 years ago
Researchers from the State University of New Jersey (Rutgers) are reporting a dramatic increase in teen use and overdoses from benzodiazepine.
The total number of teens taking and overdosing from benzodiazepines, commonly prescribed anxiety medications, has risen dramatically over the past decade, according to a national study coauthored by Rutgers researchers.
The collaborative research, ...
Source: Thailand Medical News Dec 23, 2019 4 years ago
Most of the time, getting an ultrasound is a relatively easy procedure for most people, as a technician gently presses a probe against a patient’s skin, sound waves generated by the probe travel through the skin, bouncing off muscle, fat, and other soft tissues before reflecting back to the probe, which detects and translates the waves into an image of what lies beneath.Normal ultrasound doe...
Source: Thailand Medical News Dec 23, 2019 4 years ago
As a result of recent disappointments over clinical trials targeting amyloid plaque build-up in Alzheimer’s disease, researchers now are focusing more attention on misfolded tau protein, another culprit in brain diseases that cause dementia.
A new study published in Science Translational Medicine finds that targeting abnormal tau through the suppression of a gene called MSUT2 (mam...
Source: Thailand Medical News Dec 23, 2019 4 years ago
Researchers from University Of California, Davis (UC Davis) in a new study found that the louder people talk, the more airborne particles they emit, making loudness a potential factor in spreading airborne diseases. The study, led by chemical engineering Ph.D. student Dr Sima Asadi in Professor William Ristenpart’s group, looked at particle emission during speech as a function of loudness, a...
Source: Thailand Medical News Dec 23, 2019 4 years ago
An inexpensive and fast yet sensitive technique to detect cancer markers is bringing researchers closer to a "liquid biopsy"- a test using a small sample of blood or serum to detect cancer, rather than the invasive tissue sampling routinely used for diagnosis.
Medical researchers at the University of Illinois developed a method to capture and count cancer-associated microRNAs, or tiny...
Source: Thailand Medical News Dec 23, 2019 4 years ago
Researchers from University Of California, Los Angeles have now reported to Thailand Medical News that they have devised a diagnostic blood test that can quickly and sensitively diagnoses Lyme disease at its early stages.
More 300,000 cases of Lyme disease, which is caused by the tick-borne bacteria Borrelia burgdorferi, are diagnosed in the U.S. each year, according to the U.S. Centers for Dis...
Source : Thailand Medical News Dec 22, 2019 4 years ago
Numerous past studies have long found a correlation between obesity in children and decreased executive function. A New research published in JAMA Pediatrics, based on data mined from a massive national research study, suggests that a change in brain structure: a thinner prefrontal cortex,may help explain that interrelationship.
Dr Jennifer Laurent, an associate professor in the Department...
Source: Thailand Medical News Dec 22, 2019 4 years ago
Medical researchers identify possible link between cannabis use and detrimental structural changes to heart. Regular cannabis use could affect the structure and function of the heart, research led by a team at Queen Mary University of London suggests.
By analyzing MRI images from the UK Biobank population study, the team identified an association between regular cannabis use and ...
Source: Thailand Medical News Dec 22, 2019 4 years ago
Consuming watermelon in the form of powdered supplements helped adult obese mice avoid some detrimental health effects of an unhealthy diet, according to a new Oregon State University study.
The new study was published in the Journal of Nutrition.
An important next step in this research would be a human clinical trial, said study co-author Dr Neil Shay, professor of food science in OSU...
Source: Thailand Medical News Dec 22, 2019 4 years ago
According to a new study at Karolinska Institutet in Sweden and the University of Oxford in the UK, Glutamine could help people with obesity reduce inflammation of fat tissue and reduce fat mass, The researchers also show how glutamine levels can alter gene expression in several different cell types. However, more research is needed before glutamine supplementation may be recommended as a tr...
Source: Thailand Medical News Dec 22, 2019 4 years ago
The anticlotting agent Heparin is frequently employed to mitigate the risk of clot formation in the leg veins following surgery, to treat venous thromboses and to prevent thrombotic occlusions of arteries in patients at risk for heart attacks. However, the agent can also lead to a reduction in the numbers of thrombocytes (otherwise known as platelets) in the bloodstream, an effect known as heparin...
Source: Thailand Medical News Dec 22, 2019 4 years ago
A detailed collation that can lead to a comprehensive map of genes necessary for cancer survival is one step closer, following the validation of the two largest CRISPR-Cas9 genetic screens in 725 cancer models, across 25 different cancer types. Scientists at the Wellcome Sanger Institute and the Broad Institute of MIT and Harvard compared the consistency of the two datasets, independently verifyin...
Source: Thailand Medical News Dec 22, 2019 4 years ago
Thailand Diabetes
In a study of the first kind, medical scientists have been able to observe people developing Type 2 diabetes and confirmed that fat over-spills from the liver into the pancreas, triggering the chronic condition.
The new research, led by Professor Roy Taylor at Newcastle University, UK, is published in the academic journal, Cell Metabolism.
The research involved a ...
Source : Thailand Medical News Dec 21, 2019 4 years ago
Hepatic steatosis or fatty liver disease which develops when the body produces too much fat or doesn't metabolize fat efficiently enough, affects around 25% of the global population. Excess fat is stored in liver cells, where it accumulates and can cause fatty liver and other diseases.
A new research study just published in the journal Cell Reports, reveals for the first time that SIRT...
Source: Thailand Medical News Dec 21, 2019 4 years ago
Prostate Cancer
According to a new University College of London-led computer modelling study, nearly one in six deaths from prostate cancer could be prevented if targeted screening was introduced for men at a higher genetic risk of the disease.
Prostate cancer is the most common form of cancer in men with around 1.3 million new cases diagnosed globally each year and more than 400,000 men a yea...
Source: Thailand Medical News Dec 21, 2019 4 years ago
Novartis, the Swiss pharmaceutical company is preparing to give away 100 doses of the world's most expensive drug, which treats a rare childhood disorder, through a special recipient selection process.
The pharmaceutical giant announced this week that starting next month, its AveXis unit will begin distributing doses of Zolgensma, a one-time gene treatment for spinal muscular atrophy, also ...
Source: Thailand Medical News Dec 21, 2019 4 years ago
Medical researchers at Indiana University School of Medicine have made several novel discoveries in the field of spinal cord injuries (SCI) and most recently, the team led by Dr Xiao-Ming Xu, Ph.D., has been working to determine how to activate movement after a spinal cord injury at the ninth thoracic level, where nerve fibers from the brain down to the spinal cord are interrupted. Instead of focu...
Source: Thailand Medical News Dec 21, 2019 4 years ago
Thailand Supplements
A new study by the University Of Oxford shows that taking Vitamin D alone does not prevent bone fractures. Instead older individuals have to take both calcium and Vitamin D together to see actual effects of curbing the risk of a bone fracture, the new study concludes.
The detailed analysis of 28 past studies found that older adults with higher blood levels of vitamin...
Source: Thailand Medical News Dec 21, 2019 4 years ago
Patients suffering from breast cancer who take the dietary supplements known as antioxidants, as well as iron, vitamin B12, and omega-3 fatty acids, during chemotherapy may be at increased risk of disease recurrence and death, according to new study results appearing in the Journal of Clinical Oncology.
Researchers from the SWOG Cancer Research Network, a cancer clinical trials network fun...
Source: Thailand Medical News Dec 21, 2019 4 years ago
A new oncological research study conducted by the Wistar Institute demonstrated that NAMPT, an enzyme critical for NAD+ biosynthesis, mediates selection of stem-like chemoresistant cells following cisplatin treatment. Researchers showed that a combination of cisplatin treatment with pharmacological inhibition of NAMPT suppresses the outgrowth of resistant cancer cells in vitro and prolongs s...
Source: Thailand Medical News Dec 20, 2019 4 years ago
According to new research, eating two apples a day has been shown to help keep cholesterol down and fight heart disease risk
In a study paper published in the American Journal of Clinical Nutrition, a team of scientists led by the University of Reading in collaboration with the Fondazione Edmund Mach (FEM) Institute, Italy found that eating apples which were rich in fibre and compounds cal...
Source: Thailand Medical News Dec 20, 2019 4 years ago
An objective way of measuring flavanol intake has been developed, which could help nutritional experts assess the link between these compounds and their health benefits at scale.
Researchers from the University of Reading, the University of California Davis and Mars, Incorporated have, In the first study of its kind published in Nature Scientific Reports, identified and validated the first...
Source: Thailand Medical News Dec 20, 2019 4 years ago
New research show that in laboratory experiments, a metabolic inhibitor was able to kill a variety of human cancer cells of the skin, breast, lung, cervix and soft tissues through a non-apoptotic route called catastrophic macropinocytosis.
In animal model xenograft studies, the inhibitor acted synergistically with a common chemotherapy drug, cyclophosphamide, to reduce tumor&nb...
Source: Thailand Medical News Dec 20, 2019 4 years ago
Cycling and walking to work were associated with fewer heart attacks across 43 million adults in England, according to a new national study. Co-authored by Alistair and Jonny Brownlee, Olympic-medal winning triathletes and alumni of the University of Leeds, the research suggests that active travel could provide important health benefits.
In places where walking or cycling to work were...
Source: Thailand Medical News Dec 20, 2019 4 years ago
OVFs or Osteoporotic vertebral fractures are a prevalent skeletal condition in the elderly, occurring due to a net loss in bone density with the inevitable onset of aging. Unfortunately, they are largely under-diagnosed until detected by clinicians through radiological scans. These fractures have a huge impact on daily lifestyle as the spine is responsible for bodily movements and stability. Howev...
Source:Thailand Medical News Dec 20, 2019 4 years ago
President Trump's administration unveiled a plan Wednesday to allow imports of lower-priced prescription drugs from Canada and other countries, but it was opposed by Ottawa, which said the scheme threatened its own medicine stocks.
Typically, Americans spend an average of $1,200 on prescription drugs per year, more than in any other country in the world and the US president ...
Source:Thailand Medical News Dec 20, 2019 4 years ago
White collar workers who spend long hours on the job are more likely to have high blood pressure, including a type that can go undetected during a routine medical appointment, according to a new study published today in the American Heart Association's journal Hypertension.
Hypertension or high blood pressure affects nearly 30 per cent of adults globally aged 18 and older and is ...
Source: Thailand Medical News Dec 19, 2019 4 years ago
CBT or Cognitive Behavioural Therapy for patients with social anxiety not only helps to reduce anxiety levels but also seems to protect against accelerated cellular ageing, a study involving researchers at Karolinska Institutet published in the journal Translational Psychiatry reports.
Lead author Dr Kristoffer Månsson, researcher at the Department of Clinical Neuroscience at Ka...
Source: Thailand Medical News Dec 19, 2019 4 years ago
More than half of American adults will be obese within a decade and one-quarter will be severely so, a new report predicts.
The new study corrects for a weakness in previous estimates that may have made the problem seem not as big as it really is. Those estimates often relied on national health surveys and people tend to understate their weight in those. The research used a deca...
Source: Thailand Medical News Dec 19, 2019 4 years ago
Medical researchers at Children's Medical Center Research Institute at University Of Texas Southwestern (CRI) have uncovered why certain melanoma cells are more likely to spread through the body. The discovery opens up a potential new avenue of treatment and could be used to help reduce the proportion of patients who progress from stage 3 melanoma to more-deadly stage 4 cancer.
Dr. Sean Mor...
Source: Thailand Medical News Dec 19, 2019 4 years ago
University of Southampton and University Of Cambridge researchers have developed a new technique to analyze biochemical changes unique to Huntington's disease. The breakthrough has the potential to lead to the improved diagnosis of disease onset and possibly better ways to track the effects of new treatments.
Typically, huntington's disease damages nerve cells in the brain and typically...
Source: Thailand Medical News Dec 19, 2019 4 years ago
Genome and oncology researchers have identified a genetic signature with prognostic value for certain kinds of breast cancer. The discovery also contributes to a better understanding of the molecular mechanisms of pathological angiogenesis, the aberrant proliferation of blood vessels that occurs during cancer and other diseases.
The new research combined a study of the genes involved in retinop...
Source: Thailand Medical News Dec 19, 2019 4 years ago
A pharmaceutical drug used to treat and prevent HIV/AIDS is showing promise as a potential therapy for Alzheimer's disease, and Vanderbilt University biochemist Dr F. Peter Guengerich, Ph.D., is aiding efforts to make this approach to improving memory and cognitive function even better.
Dr Guengerich and colleagues at Case Western Reserve University School of Medicine in Cleveland, Ohio, rep...
Source : Thailand Medical News Dec 19, 2019 4 years ago
It was announced yesterday by the World Health Organization (WHO) that it had for the first time approved a "biosimilar" medicine, one derived from living sources rather than chemicals, to make breast cancer treatment affordable to women globally.
The drug Trastuzumab has shown "high efficacy" in curing early stage breast cancer and in some cases more advanced forms of the d...
Source : Thailand Medical News Dec 19, 2019 4 years ago
Research led by Monash University Professor Dr Eric Morand offers the first real hope for the treatment of lupus, a disease which affects 1.6 million people in the US and more than 5.4 million globally, 89% women and for which there is no cure.
The study findings were published in the New England Journal Of Medicine (NEJM). The results are of an international, three-year, Phase 3 trial of...
Source: Thailand Medical News Dec 18, 2019 4 years ago
Despite early antiretroviral therapy, or ART, has ensured less deadly outcomes for children living with and exposed to HIV, studies show the virus still may affect the brain. HIV may disrupt neurodevelopment, affecting how children learn, reason and function.
Dr Michael Boivin, professor and director of the Psychiatry Research Program in the Michigan State University College of Osteopathic Medi...
Source: Thailand Medical News Dec 18, 2019 4 years ago
Epigallocatechin gallate (EGCG), an antioxidant found in the green tea plant could become key to tackling tuberculosis one day, a team of international scientists led by Nanyang Technological University (NTU), Singapore has found. Through laboratory investigations, the team led by NTU Professor Dr Gerhard Grüber discovered how the prominent compound, known as epigallocatechin g...
Source: Thailand Medical News Dec 18, 2019 4 years ago
Researchers from Tulane University, New Orleans have for the first time assessed the impact on the risk of heart or blood vessel problems from the combination of sleep patterns and genetic susceptibility to cardiovascular disease. The study, which is published in the European Heart Journal, found that even if people had a high genetic risk of heart disease or stroke, this...
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