Nikhil Prasad Fact checked by:Thailand Medical News Team Feb 17, 2026 1 hour, 45 minutes ago
Medical News: A new scientific study has uncovered a surprising biological signal that could transform how endometriosis is detected and understood. Researchers have found that women suffering from endometriosis have significantly higher levels of a hormone-related protein called chromogranin A and its derivatives in their blood and abdominal fluid. This discovery offers new hope for earlier diagnosis and better management of a disease that affects millions of women worldwide.
Scientists discover elevated hormone-related proteins that could help detect and explain endometriosis earlier
Endometriosis is a chronic condition where tissue similar to the lining of the uterus grows outside the womb, often causing severe pelvic pain, inflammation, and infertility. Experts estimate that up to 10 percent of women of reproductive age are affected, yet diagnosis can take years because symptoms often overlap with other conditions. In this
Medical News report, scientists have identified key biochemical changes that may serve as warning signals of the disease and help doctors detect it more accurately.
Scientists From Leading Polish Medical Institutions Conduct Study
The research was carried out by scientists from multiple respected institutions, including the Department of Histology and Embryology at the Centre of Biostructure Research, Medical University of Warsaw, Poland; the National Medical Institute of the Ministry of Interior and Administration, Warsaw; the Medical Centre of Postgraduate Medical Education, Warsaw; the Department of Obstetrics, Gynaecology and Gynaecological Oncology, Medical University of Warsaw; the Women’s Health Research Institute, Calisia University, Poland; OVIklinika Infertility Center, Warsaw; and the University of Siedlce, Poland.
The study involved 125 women. Of these, 65 had confirmed endometriosis, while 60 women without the disease served as controls. Researchers collected blood samples and peritoneal fluid, which is the fluid found inside the abdominal cavity. They then measured levels of chromogranin A and two related peptides called catestatin and pancreastatin.
Major Hormone-Linked Protein Found Elevated in Patients
The results were clear and striking. Women with endometriosis had significantly higher levels of chromogranin A, catestatin, and pancreastatin in both their blood and abdominal fluid compared to healthy individuals. These elevated levels were strongly linked with the presence and severity of the disease.
Chromogranin A is a protein normally produced by specialized cells in the body and plays an important role in controlling inflammation, blood vessel growth, and immune system activity. These biological processes are also involved in endometriosis, which helps explain why the protein increases during the disease.
Researchers also found that higher levels of these markers were especially common in women with more advanced stages of endometriosis. This suggests that as the disease progresses, the body produces even more of these hormone-related molecules.
ng>Strong Evidence That These Molecules Could Help Diagnose Disease
One of the most important findings was that chromogranin A showed strong diagnostic potential. In statistical tests, the presence of elevated chromogranin A levels was able to accurately distinguish between women with and without endometriosis in many cases.
The abdominal fluid measurements showed the strongest predictive value, but blood levels were also clearly elevated. This raises the possibility that simple blood tests could one day help detect the disease earlier, reducing the need for invasive surgery, which is currently required for confirmation.
In addition, scientists found strong correlations between chromogranin A and its related peptides. This suggests that the increase originates from a common biological pathway, reinforcing the importance of this protein system in the disease process.
New Clues into How Endometriosis Develops
The study also sheds light on why endometriosis persists and worsens over time. Chromogranin A and its derivatives influence immune responses, inflammation, and the formation of new blood vessels. These processes can help abnormal tissue survive and grow outside the uterus.
Researchers believe these molecules may contribute to the chronic inflammation and immune system dysfunction seen in endometriosis. This could explain why the body fails to eliminate misplaced tissue, allowing the disease to continue.
Conclusions
This important study provides compelling evidence that chromogranin A and its related peptides play a significant role in endometriosis. Their elevated levels not only reflect disease presence but also appear to increase as the condition becomes more severe. These findings suggest that chromogranin A could become a valuable biomarker for early diagnosis and disease monitoring. While further research is needed, this discovery could eventually lead to simple blood tests and new treatment strategies that target the underlying biological mechanisms driving endometriosis progression and symptoms.
The study findings were published in the peer reviewed Journal of Clinical Medicine.
https://www.mdpi.com/2077-0383/15/4/1567
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