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Source: COVID-19 Drugs  Nov 09, 2021  2 years, 5 months, 1 week, 2 days, 4 hours, 26 minutes ago

COVID-19 Drug Breakthrough! South Korean Study Demonstrates Potential Of Using Hemin To Treat COVID-19 Via Heme Oxygenase-1 Induction

COVID-19 Drug Breakthrough! South Korean Study Demonstrates Potential Of Using Hemin To Treat COVID-19 Via Heme Oxygenase-1 Induction
Source: COVID-19 Drugs  Nov 09, 2021  2 years, 5 months, 1 week, 2 days, 4 hours, 26 minutes ago
COVID-19 Drugs: A new COVID-19 drug breakthrough study led by researchers from the Department of Infectious Diseases, Konkuk University-Gwangjin-gu-South Korea along with help from Chung-Ang University- Gyeonggi-South Korea has demonstrated that the pharmaceutical product called Hemin can be used to treat COVID-19 via heme oxygenase-1 Induction.

The antiviral effects of heme oxygenase-1 (HO-1), a cytoprotective enzyme that inhibits the inflammatory response and reduces oxidative stress, have been investigated in several viral infections.
 
To confirm whether HO-1 suppresses SARS-CoV-2 infection, the study team assessed the antiviral activity of hemin, an effective and safe HO-1 inducer, in SARS-CoV-2 infection.
 
The study findings showed that treatment with hemin efficiently suppressed SARS-CoV-2 replication (selectivity index: 249.7012). Besides, the transient expression of HO-1 using an expression vector also suppressed the growth of the virus in cells. Free iron and biliverdin, which are metabolic byproducts of heme catalysis by HO-1, also suppressed the viral infection. Additionally, hemin indirectly increased the expression of interferon-stimulated proteins known to restrict SARS-CoV-2 replication.
 
The study findings suggest that HO-1, induced by hemin, effectively suppressed SARS-CoV-2 in vitro. Therefore, HO-1 could be potential therapeutic candidate for COVID-19.
 
The study findings were published in the peer reviewed journal: Scientific Reports (Nature)
https://www.nature.com/articles/s41598-021-01054-3
 
To date there is no licensed antiviral drug in the market that specifically treats the SARS-CoV-2 infection. Considering the devastating effects caused by the COVID-19 pandemic, identifying antiviral drugs that are effective against SARS-CoV-2 is of the utmost importance. To date, more than more than a quarter billion individuals globally have been infected with the SARS-CoV-2 virus and more than 5.06 million people have died from the COVId-19 disease.
 
Some of the proposed overpriced antiviral drugs to treat COVID-19 that are being promoted by the Western pharmaceutical giants and the elites controlling the COVId-19 narratives are extremely toxic and mutagenic.
 
Hemin is a pharmaceutical preparation available under the trade names Panhematin® and Normosang®, and has a well-established safety profile. There are also many cheap generic versions of it available across the globe.
 
Hemin (haemin; ferric chloride heme) is an iron-containing porphyrin with chlorine that can be formed from a heme group, such as heme B found in the hemoglobin of human blood.
 
Hemin is endogenously produced in the human body, for example during the turnover of old red blood cells. It can form inappropriately as a result of hemolysis or vascular injury. Several proteins in human blood bind to hemin, such a