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COVID-19 News- New Variants In China BF.7 With C1243F Spike Mutation  Dec 27, 2022  1 month ago
COVID-19 News: Multiple New Variants In China Could Be Behind Increasing Disease Severity Including New BF.7 Variant With C1243F Spike Mutation!
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COVID-19 News: Multiple New Variants In China Could Be Behind Increasing Disease Severity Including New BF.7 Variant With C1243F Spike Mutation!
COVID-19 News- New Variants In China BF.7 With C1243F Spike Mutation  Dec 27, 2022  1 month ago
COVID-19 News: Researchers are concerned that already a few new concerning SARS-CoV-2 variants and sub-lineages have emerged in China and are contributing to increased disease severity and mortality being seen in the country the last three weeks.


Pic Credit: DamienArt - stock.adobe.com
 
Just in the last 24 hours, researchers have identified new variant ie BF.7 that posts an additional C1243F spike mutation that is also seen in another new variant hat seems to be also driving disease severity in other countries ie the BQ.1.2 variant.
https://github.com/cov-lineages/pango-designation/issues/1470
 
This new BF.7 variant with a C1243F spike mutation also spots other unique mutations such as ORF7a:H47Y, ORF1b:L238F, ORF1a:V274L and also another spike mutation C29632T.
 
The ORF7a protein is able to affect autophagy, interferons and monocytes of the human host and is involved with viral replication
https://pubmed.ncbi.nlm.nih.gov/35670302/
 
https://www.sciencedirect.com/science/article/pii/S2589004221001553
 
https://www.frontiersin.org/articles/10.3389/fimmu.2021.708264/full
 
https://www.tandfonline.com/doi/abs/10.1080/15548627.2022.2084686
 
It has also been found to inhibits the antiviral effect of the host factor SERINC5, leading to disease severity as a result of cell fusion.
https://www.nature.com/articles/s41467-022-30609-9
 
Studies have also shown that the ORF7a protein acts as an antagonist to the human host antiviral BST2 or tetherin, a key component of the innate immune system.
https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00313-0
 
The ORF7a protein has also been found to activate certain human host inflammatory molecules, leading to disease severity.
https://journals.asm.org/doi/10.1128/mbio.00971-22
 
Some researchers are also speculating that the new mutations found in this BF.7 variant with the ORF7a:H47Y might be also involved with Cathepsin L upregulation that also leads to disease severity.
https://www.frontiersin.org/articles/10.3389/fcimb.2020.589505/full
 
Besides the new BF.7 variant with additional mutations found in China, it is also suspected that two other new variants found also in Japan could also be at play in China. These two other new variants have already been covered in our previous COVID-19 News updates.
 
One is new BF.5 variant with a unique mutation of its ORF1A protein: ORF1a: I2873V and the other is new BA.5.2.1 variant with mutations in ORF1a ie I2873V along with the following mutations: S: A1020S,ORF7a: H47Y and ORF9b: K40R.
https://www.thailandmedical.news/news/breaking-covid-19-news-is-the-new-bf-5-variant-with-orf1a-i2873v-mutation-driving-covid-19-deaths-in-japan-urgent-research-warranted
 
https://www.thailandmedical.news/news/breaking-covid-19-news-is-the-new-bf-5-variant-with-orf1a-i2873v-mutation-driving-covid-19-deaths-in-japan-urgent-research-warranted
 
Thailand Medical News will continue to provide updates on various other new variants emerging in China despite a ban by its government officials to release such data as we have various other Chinese experts and scientists who are constantly feeding us with developments in the country.
 
For the latest COVID-19 News keep on logging to Thailand Medical News.

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