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Nikhil Prasad  Fact checked by:Thailand Medical News Team Sep 20, 2023  2 months, 2 weeks, 6 days, 1 minute ago

BREAKING NEWS! Study Finds Most Sudden Unexplained Deaths With Negative COVID-19 Swab Test Were Due To High SARS-CoV-2 Viral Loads In Lungs!

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BREAKING NEWS! Study Finds Most Sudden Unexplained Deaths With Negative COVID-19 Swab Test Were Due To High SARS-CoV-2 Viral Loads In Lungs!
Nikhil Prasad  Fact checked by:Thailand Medical News Team Sep 20, 2023  2 months, 2 weeks, 6 days, 1 minute ago
COVID-19 News: In a world gripped by the COVID-19 pandemic, the pursuit of answers is relentless. As we navigate through uncharted waters, new revelations emerge, challenging our understanding of the virus and its impact on human lives.

Massive congestion of the lung tissue, dilated capillaries - a child aged 7,
Source: Prof. Mirosław Parafiniuk

A recent study conducted by the Forensic Medicine Department at the Pomeranian Medical University in Szczecin, Poland, has shed light on a startling phenomenon: a significant number of sudden unexplained deaths, even in individuals with negative COVID-19 swab tests, can be attributed to high SARS-CoV-2 viral loads in the lungs. This groundbreaking research has profound implications for our comprehension of COVID-19 and its consequences, particularly among children.
The Pandemic's Unseen Toll
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has left a profound mark on humanity. It has taken countless lives and brought healthcare systems to their knees. Amid this global crisis, forensic autopsies have taken on new significance, as they offer valuable insights into the mysterious ways in which the virus operates and claims lives.
Numerous studies, cases reports and past COVID-19 News reports have showed the increasing trends of unexplained sudden deaths in otherwise healthy individuals and even in infants and young children and many tested negative for COVID-19 prior to their deaths!
The study findings present a summary of an autopsy-based study conducted on 23 individuals who experienced sudden and unexplained deaths. It is crucial to highlight that some of these cases involved children whose initial cause of death was attributed to Sudden Infant Death Syndrome (SIDS). These autopsies, carried out meticulously at the Department of Forensic Medicine and Forensic Genetics, Pomeranian Medical University in Szczecin, were enriched with molecular diagnostics of the SARS-CoV-2 virus and detailed histopathological analysis of lung tissue.
The Dual Nature of COVID-19
Initially, COVID-19 was perceived as primarily attacking the respiratory system. However, only through autopsies combined with clinical data did we discover that this virus is far more insidious, causing multi-organ dysfunction. Forensic autopsies, distinct from clinical dissections, involve analyzing the internal organs without access to the deceased's clinical history. This research aims to unravel the factors contributing to COVID-19-related deaths in the absence of such information.
The Surprising Persistence of SARS-CoV-2
One of the most perplexing aspects of SARS-CoV-2 is its persistence even after death. While previous studies have identified the presence of the virus's genetic material in deceased individuals for up to several days, the exact duration of its viability in the human body remains uncertain. Detecting the virus's genome post-mortem raises questions about its infectiousness and the source of infection for pathologists.
Research on other viruses, such as the influenza virus and the Ebola virus, has shown that their genomes can remain detectable in corpses for extended periods. The SARS-CoV-2 virus, being an RNA virus like the influenza virus, shares this trait. Factors like temperature and humidity play a role in the virus's viability post-mortem. Consequently, it is plausible that the transmission of the virus from the deceased is possible even after death, despite stringent safety measures during autopsies.
The Risk of Cadaver Transmission
The risk of infection transmission, both to autopsy staff and bereaved families, is a significant concern. This risk is particularly pronounced in cases involving the SARS-CoV-2 virus due to its unique genome structure, which dictates its infectivity. Thus, the argument for molecular testing (RT-PCR) of every body entering the Department of Forensic Medicine, especially during a pandemic, gains legitimacy.
Children and COVID-19: An Evolving Understanding
One of the most startling findings of this study is the reevaluation of sudden child deaths, often attributed to SIDS. SIDS remains a mysterious entity with an unclear etiology. Some theories suggest an association with the immaturity of a child's respiratory system. However, the presence of the SARS-CoV-2 virus in child deaths classified as SIDS raises new questions about potential viral contributions to these tragedies.
The Findings: COVID-19 as a Common Denominator
This study presents compelling evidence that the SARS-CoV-2 virus played a central role in all the examined cases, even those involving infants. The molecular test results and histopathological analyses consistently pointed to COVID-19 as the cause of death. In the case of infants, there is a suspicion that chronic viral infections might intersect with SIDS, as evidenced by distinct lung patterns observed in these cases. Elderly individuals who underwent autopsies also displayed chronic inflammatory processes and lung tissue fibrosis, underscoring the multi-faceted nature of COVID-19's impact.
The Role of Autopsies in a Global Crisis
The COVID-19 pandemic has placed an unprecedented burden on global healthcare systems and the medico-forensic community. This has prompted some health authorities to issue guidelines for waiving autopsies for COVID-19-suspected cases. However, autopsies remain invaluable in understanding the pathophysiology of the disease, the mechanisms of death, and the complications arising from COVID-19, particularly clotting disorders.
False Negative Results in Swab Tests
The standard diagnostic method for COVID-19 is the RT-PCR test, typically performed using a nasopharyngeal swab. However, this study has revealed the potential for false-negative results, even in individuals with high viral loads in the lungs. The concentration of viral RNA in the upper respiratory tract peaks shortly before or after symptom onset, and it fluctuates throughout the day. This variation can result in false negatives, especially in the later stages of infection. These findings question the efficacy of nasopharyngeal swabs as the sole diagnostic tool and emphasize the importance of considering other diagnostic methods, such as bronchoalveolar lavage and sputum samples, which may yield more accurate results.
Mutations and the Mystery of "Gene Dropping Out"
The SARS-CoV-2 virus's genetic plasticity and high mutation rate pose additional challenges in diagnosing and understanding the virus's behavior. This study observed instances of "gene dropping out" in eight of the twenty-three cases, highlighting the need for ongoing research into the virus's ever-evolving genetic landscape.
Children as Silent Carriers
Children, with their milder COVID-19 symptoms, may be silent carriers of the virus. This study found that children often exhibited lower viral loads than adults but could still transmit the infection. The possibility of false-negative test results in children further complicates efforts to control the virus's spread.
The research conducted by the Forensic Medicine Department at the Pomeranian Medical University in Szczecin, Poland, has illuminated a previously unexplored aspect of the COVID-19 pandemic. It has shown that high SARS-CoV-2 viral loads in the lungs can be a crucial factor in sudden unexplained deaths, even in individuals with negative nasopharyngeal swab tests. This discovery challenges our understanding of COVID-19, particularly in children, and emphasizes the importance of postmortem molecular diagnostics to comprehensively assess the cause of death and the potential for virus transmission.
As the world continues to grapple with the COVID-19 pandemic, rigorous adherence to safety protocols and standard procedures remains paramount. This study underscores the need for postmortem molecular diagnostics to provide a more comprehensive understanding of COVID-19-related deaths and to minimize the risk of virus transmission. It also calls for continued research into the virus's behavior, mutations, and its impact on different age groups. In
The study findings were published in the peer reviewed journal: Diagnostics.
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