COVID-19 Genetics Study Finds That CD147 rs8259T>A Variant Is A Risk Factor For COVID-19 In The Mexican Population
COVID-19-Genetics - CD147 rs8259T>A Variant - Risk Factor - COVID-19 - Mexican Jul 29, 2023 8 months, 4 weeks, 1 day, 9 hours, 42 minutes ago
COVID-19-Genetics: The coronavirus disease 2019 (COVID-19) pandemic has posed a significant global health challenge caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 has become a global public health crisis, leading to millions of deaths worldwide.
The virus exhibits a wide range of clinical manifestations, from mild flu-like symptoms to severe respiratory failure.
In recent research, the extracellular matrix metalloproteinase inducer (EMMPRIN), also known as cluster of differentiation 147 (CD147) or BASIGIN, has been identified as a potential facilitator of viral entry and replication within host cells.
However, the impact of the CD147 rs8259T>A single nucleotide variant (SNV) on SARS-CoV-2 susceptibility remains poorly understood. This study aimed to investigate the association between the CD147 rs8259T>A variant and COVID-19 susceptibility in individuals from Mexico.
The virus's ability to infect host cells primarily depends on interactions between the viral spike (S) protein and the human receptor angiotensin-converting enzyme-2 (ACE2). While ACE2 was initially identified as the primary host cell receptor for the S protein, recent studies have revealed the involvement of other molecules, such as CD147, in mediating viral infection. CD147 is a glycosylated transmembrane glycoprotein expressed in various immune cells and is known to trigger inflammation and immune cell activation. Single nucleotide variants (SNVs) have been a subject of genetic research to understand their influence on infectious disease susceptibility, including COVID-19.
The
COVID-19-Genetics research was conducted by genotyping the CD147 rs8259T>A SNV in 195 patients with COVID-19 and 185 healthy controls from Mexico. Additionally, the study measured the expression levels of CD147, TNF mRNA, and miR-492 from whole blood of COVID-19 patients through RT-q-PCR.
The study findings revealed a significant association between the CD147 rs8259T>A SNV and susceptibility to COVID-19 in the Mexican population. Specifically, the T allele and the TT genotype were identified as risk factors for COVID-19. However, there were no observed differences in CD147, TNF, or miR-492 expression levels based on the genotypes of the CD147 rs8259T>A SNV in patients with COVID-19.
CD147 has been implicated as another human receptor for the S protein of SARS-CoV-2, enabling viral entry. Some previous studies have suggested that certain variants in the CD147 gene may influence COVID-19 susceptibility and severity. In the Mexican population, this study found an association between the CD147 rs8259T>A variant and COVID-19 susceptibility, which differed from the findings in the Ukrainian population.
Genetic background and sample size differences may contribute to these discrepant results. Additionally, the study explored the expression levels of CD147 and related genes but did not find any significant associations with COVID-19 severity.
Conclusion
The CD147 rs8259T>A variant was identified as a risk factor for COVID-19 in the Mexican population, shedding light on the potential role of CD147 in COVID-19 pathogenesis. Understanding the genetic factors influencing COVID-19 susceptibility can contribute to personalized medicine and targeted therapeutic interventions. However, further research in
diverse populations and exploration of additional genetic variants remains essential to comprehensively understand the genetic basis of COVID-19 susceptibility.
The study findings were published in the peer reviewed journal: Microorganisms
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