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H7N9 News - Camels - Mutations  Mar 15, 2023  6 months, 2 weeks, 5 days, 8 hours, 50 minutes ago

BREAKING NEWS! Chinese Scientists Shockingly Discovers That H7N9 Avian Virus Has Mutated And Infects Camels In Inner Mongolia Now!

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BREAKING NEWS! Chinese Scientists Shockingly Discovers That H7N9 Avian Virus Has Mutated And Infects Camels In Inner Mongolia Now!
H7N9 News - Camels - Mutations  Mar 15, 2023  6 months, 2 weeks, 5 days, 8 hours, 50 minutes ago
H7N9 News: Researchers from Yangzhou University, Yangzhou, Jiangsu-China have made a shocking discovery that the H7N9 virus has mutated and is now infecting camels in the inner Mongolia region. The discovery serves as a warning that the H7N9 is evolving and there is a very high threat of it further mutating to enable it infect humans more easily!

Distressed camel being molested in the Middle-East....The H7N9 Virus threat could
potentially be exacerbated by the fetish behvaiour of Middle-Eastern Men!
Pic Credit: David Dennis/Flickr

Influenza A virus subtype H7N9 (A/H7N9) is a bird flu strain of the species Influenza virus A (avian influenza virus or bird flu virus).
Avian influenza A H7 viruses normally circulate amongst avian populations with some variants known to occasionally infect humans. An H7N9 virus was first reported to have infected humans in March 2013, in China.
It has been reported that a past epidemic of the H7N9 virus began in October 2016 in China. The epidemic is the largest since the first epidemic in 2013 and accounts for about one-third of human cases ever reported.
The cumulative total of laboratory-confirmed cases since the first epidemic is 1,223. About 40 percent of all humans who contracted the virus have died.
The U.S.CDC estimates that the H7N9 virus has the greatest potential compared with other influenza A viruses to cause a pandemic, although the risk is low because, like other type A viruses, it is not easily transmitted between people in its current form.
The WHO or World Health Organization has identified H7N9 as " unusually dangerous virus for humans."
Most H7N9 Human infections resulted in severe respiratory illness, with a mortality rate of roughly 30 percent.
Scientists have commented on the unusual prevalence of older males among H7N9-infected patients.
It has been established that many of the human cases of H7N9 appear to have a link to live bird markets.
https://www.woah.or g/en/oie-expert-mission-finds-live-bird-markets-play-a-key-role-in-poultry-and-human-infections-with-influenza-ah7n9/
While the H7N9 subtype of influenza virus can infect birds and humans, causing great losses in the poultry industry and threatening public health worldwide, H7N9 infection in other mammals has not been reported yet till now.
The study team isolated from the nasal swabs of camels in Inner Mongolia, China, in 2020, one H7N9 subtype influenza virus, A/camel/Inner Mongolia/XL/2020 (XL).
Detailed sequence analyses revealed that the hemagglutinin cleavage site of the XL virus was ELPKGR/GLF, which is a low-pathogenicity molecular characteristic.
Interestingly, the XL virus had similar mammalian adaptations to human-originated H7N9 viruses, such as the polymerase basic protein 2 (PB2) Glu-to-Lys mutation at position 627 (E627K) mutation, but differed from avian-originated H7N9 viruses.
It was also found that the XL virus showed a higher SA-α2,6-Gal receptor-binding affinity and better mammalian cell replication than the avian H7N9 virus.
However, the new XL virus had weak pathogenicity in chickens, with an intravenous pathogenicity index of 0.01, and intermediate virulence in mice, with a median lethal dose of 4.8.
The XL virus replicated well and caused clear infiltration of inflammatory cells and increased inflammatory cytokines in the lungs of mice.
The study findings constitute the first evidence that the low-pathogenicity H7N9 influenza virus can infect camels and therefore poses a high risk to public health.
The study team pointed out that while the H5 subtype avian influenza viruses can cause serious diseases in poultry and wild birds, on rare occasions, viruses can cause cross-species transmission to mammalian species, including humans, pigs, horses, canines, seals, and minks.
The study team also said, “In contrast to the H5N1 viruses isolated from tigers recently, which displayed few genetic changes compared to the H5N1 viruses isolated from poultry, the XL virus isolated from camels had mammalian-adapted molecular markers, including alteration of receptor-binding activity on HA protein and the E627K mutation on PB2 protein, suggesting that the XL virus in camels has a great possibility to spread to humans!”
The study team also stressed, “Although the H7N9 subtype of the influenza virus can also infect both birds and humans, viral infection in other mammalian species has not been reported yet. In this study, we found that the H7N9 virus could infect camels. Notably, the H7N9 virus from camels had mammalian adaption molecular markers, including altered receptor-binding activity on the hemagglutinin protein and an E627K mutation on the polymerase basic protein 2 protein. Our findings indicated that the potential risk of camel-origin H7N9 virus to public health is of great concern.”
The study findings were published in the peer reviewed journal: Microbiology Spectrum.
For the latest H7N9 News, keep on logging to Thailand Medical News.


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