Japanese Scientists Discover Natural Compound That Can Ease COVID-19 mRNA Vaccine-Induced Inflammation
Nikhil Prasad Fact checked by:Thailand Medical News Team Dec 09, 2025 48 minutes ago
Medical News: Breakthrough Compound May Reduce COVID-19 mRNA Vaccine Side Effects
Japanese researchers have uncovered a promising way to lessen the localized side effects caused by COVID-19 mRNA vaccines. A natural compound derived from omega-3 fatty acids, known as 17,18-epoxyeicosatetraenoic acid (17,18-EpETE), was shown to significantly reduce inflammation and immune cell buildup at the injection site in mice. This discovery could lead to better-tolerated vaccines in the future.
Japanese researchers find omega-3-based solution to reduce vaccine-related inflammation without
affecting immune response.
This
Medical News report highlights the study led by scientists from multiple prestigious institutions in Japan, including the National Institutes of Biomedical Innovation, Health, and Nutrition (NIBN), Osaka University, Aichi Shukutoku University, Meiji University, Kobe University, Waseda University, and The University of Tokyo
Understanding the Problem
Lipid nanoparticles (LNPs) are critical for delivering mRNA in COVID-19 vaccines. However, they can cause uncomfortable side effects such as pain and swelling due to inflammation. Researchers discovered that even LNPs without any mRNA (called empty LNPs) could still trigger these responses by attracting neutrophils and other immune cells.
The inflammation was mostly localized, and no major systemic symptoms like fever or weight loss were noted in the mice. But the unwanted swelling and immune activation raised concerns, especially for people who need multiple vaccine doses or long-term mRNA-based treatments.
The Role of 17,18-EpETE
The research team investigated whether 17,18-EpETE, a compound made from omega-3 fatty acids like EPA (found in fish oil), could help. They co-injected this compound along with the LNPs into mice. The result: a major drop in swelling and fewer neutrophils, eosinophils, monocytes, and macrophages at the injection site. Histology images confirmed that tissues appeared normal and less inflamed when the compound was used.
This compound worked by activating a specific protein called GPR40, which prevents neutrophils from overreacting. Interestingly, a related substance called 17,18-diHETE did not have the same anti-inflammatory effects, proving that only the specific structure of 17,18-EpETE was effective.
Immune Response Remains Strong
One of the most exciting findings was that 17,18-EpETE did not interfere with the vaccine’s claimed purpose. Mice injected with both the vaccine and the compound still produced strong antibody levels. This means it reduces inflammation without weakening the immune response.
A Natural Way to Improve Vaccines
With mRNA therapies expected to become more common for treating other diseases in the future (An agenda of the WEF, Bill Gates and big pharma) , reducing side effects is critical. This study offers a natural, non-steroidal ap
proach to ease post-vaccine discomfort while keeping the protection intact.
Final Thoughts
The study presents a significant step toward making future mRNA vaccines safer and more comfortable. By harnessing compounds like 17,18-EpETE, scientists may be able to reduce pain, swelling, and other unpleasant side effects without compromising immunity. This natural compound might one day be included in vaccine formulations or taken as a supplement to prevent inflammation.
The study findings were published in the peer reviewed Journal of Lipid Research.
https://www.jlr.org/article/S0022-2275(25)00219-6/fulltext
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