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BREAKING NEWS
Source: Cortexyme, Inc, US  Jan 24, 2019  5 years ago
Cortexyme, Inc., a privately held, clinical-stage pharmaceutical company developing therapeutics to alter the course of Alzheimer's disease (AD) and other degenerative disorders, today announced publication of a foundational paper supporting its approach in Science Advances. In the paper, an international team of researchers led by Cortexyme co-founders Stephen Dominy, M.D. and Casey Lync...
Source: NYU Langone Health, New York  Jan 23, 2019  5 years ago
Most studies evaluating platelet-rich plasma (PRP) injection for facial rejuvenation and other cosmetic procedures have reported positive results, according to a critical review in the publication: Plastic and Reconstructive Surgery, the official medical journal of the American Society of Plastic Surgeons (ASPS). PRP Injections are reportedly the latests trends of 2019 for Aesthetic Clinics a...
Source: Medical College of Georgia at Augusta University  Jan 23, 2019  5 years ago
Lingering inflammation in the colon is a known risk factor for colorectal cancer and now scientists report one way it resets the stage to enable this common and often deadly cancer. Inflammation is supposed to be a short-term response to an infection or other irritant in the body that is essential to eliminating it. But when inflammation persists, it can contribute to a myriad of common condit...
Source: University Of Melbourne  Jan 22, 2019  5 years ago
Researchers studying lupus discovered that treatments similar to those already in use to treat melanoma and lung cancer, including immunotherapy, show promise for stomach cancer and may even lead to preventative treatments. Usually the symptoms of stomach or gastric cancer are hard to pick up until it’s too late, making what is a relatively common cancer an often fatal one. Survival rate...
Source: Orygen, the National Centre of Excellence in Youth Mental Health, Australia  Jan 22, 2019  5 years ago
B-group vitamins may be beneficial for maintaining concentration skills among people experiencing a first episode of psychosis, a study by researchers from Orygen, the National Centre of Excellence in Youth Mental Health, has found. The study, led by Dr Colin O'Donnell, now at Letterkenny University Hospital, and Dr Kelly Allott from Orygen, explored the impact of increasing a person's ...
Source: Wellcome Trust Sanger Institute  Jan 22, 2019  5 years ago
In the largest genetic study of osteoarthritis to date, scientists have uncovered 52 new genetic changes linked to the disease, which doubles the number of genetic regions associated with the disabling condition. Scientists at the Wellcome Sanger Institute, GSK and their collaborators analysed the genomes of over 77,000 people with osteoarthritis. Their findings, published  in Nature ...
Source: Washington University School of Medicine  Jan 22, 2019  5 years ago
A simple blood test reliably detects signs of brain damage in people on the path to developing Alzheimer’s disease – even before they show signs of confusion and memory loss, according to a new study from Washington University School of Medicine in St. Louis and the German Center for Neurodegenerative Diseases in Germany. The findings, published in Nature Medicine, may one day be ap...
Source: University of Pennsylvania  Jan 22, 2019  5 years ago
Immune cells called macrophages are supposed to serve and protect, but cancer has found ways to put them to sleep. Now researchers at the Abramson Cancer Center of the University of Pennsylvania say they've identified how to fuel macrophages with the energy needed to attack and eat cancer cells. It is well established that macrophages can either support cancer cell growth and spread or hinder ...
Source: Flinders University  Jan 21, 2019  5 years ago
A new antibiotic developed by a Flinders University researcher is being heralded as a breakthrough in the war against a drug resistant superbug. Bacteria are winning the fight against antibiotics as they evolve to fight off traditional treatments, threatening decades of advancements in modern medicine, with predictions they will kill over 10 million people by 2050. The scientific development o...
Source: Eli Lilly and Company  Jan 20, 2019  5 years ago
REACH-2 is the first positive Phase 3 hepatocellular carcinoma trial in a biomarker-selected population known for poor prognosis   Pooled data analyses of AFP-High patients in the REACH-2 and REACH trials showed an improvement of 3.1 months in median overall survival   Eli Lilly and Company (NYSE: LLY) announced that results from the global Phase 3 REACH-2 study of CYRAMZA® (ra...
Source: University of Michigan  Jan 20, 2019  5 years ago
A new study finds acupressure could be a low-cost, at-home solution to a suite of persistent side effects that linger after breast cancer treatment ends. Researchers from the University of Michigan Rogel Cancer Center reported in 2016 that acupressure helped reduce fatigue in breast cancer survivors. In the new study, they looked at the impact of acupressure on symptoms that frequently accompan...
Thailand Medical News  Jan 20, 2019  5 years ago
Positive news for Thailand’s healthcare sector was highly welcome when Bloomberg released their Global Health Care Efficiency Index in the last quarter of 2018. Thailand Medical News reviews these extremely positive results and suggest  why momentum must be maintained as well as 2 challenges that must be addressed in order for this momentum to be carried forward on a continuous basis....
Source: Netherlands Institute for Neuroscience - KNAW  Jan 20, 2019  5 years ago
Researchers from the Netherlands Institute for Neuroscience (NIN) and the Leiden University Medical Center (LUMC) have shown that treatment using gene therapy leads to a faster recovery after nerve damage. By combining a surgical repair procedure with gene therapy, the survival of nerve cells and regeneration of nerve fibers over a long distance was stimulated for the first time. The discovery, pu...
Source: American Heart Association  Jan 19, 2019  5 years ago
Flu has so far infected more than 32 million Asians this season, and seasonal fluctuations are making their rounds. If you've been hit by either, you may be thinking about heading to your local pharmacy to relieve your aches, pains and congestion. But before you do, you need to consider how some over-the-counter cold medicines may impact your heart. "People with uncontrolled high ...
Thailand Medical News  Jan 19, 2019  5 years ago
The US FDA  and EU has approved a new sublingual formulation of sufentanil, Dsuvia, for the management of acute pain in adults in medically supervised healthcare settings, such as hospitals, surgical centers, and emergency departments. The drug is supplied in a 30 microgram tablet in a single-dose, prefilled applicator for administration by a healthcare professional, and it will not be availa...
Thailand Medical News  Jan 19, 2019  5 years ago
Quell is a US FDA cleared, over-the-counter wearable therapeutic device for chronic pain. Transcutaneous electrical nerve stimulation (TENS) is a therapy that has been around for decades. It is used to treat pain and a few other conditions, but over those decades it has gotten a bit stale. New companies, though, are taking TENS therapy to a new level and NeuroMetrix is one of the leaders...
Source: Hong Kong Baptist University  Jan 19, 2019  5 years ago
Epstein-Barr virus infects more than 95 percent of people, usually without symptoms. But sometimes its persistence in cells can lead to tumor formation. Now, researchers from Hong Kong and the UK have developed a fluorescing, molecular-sized probe, called L2P4, which can inhibit Epstein-Barr-related tumor growth while allowing researchers to see the targeted tumor cells. Epstein-Barr v...
Source: US FDA  Jan 18, 2019  5 years ago
The Food and Drug Administration (FDA) has issued a safety alert regarding the possibility of an increased risk of death associated with the use of paclitaxel-coated balloons and paclitaxel-eluting stents for the treatment of peripheral arterial disease (PAD). The FDA's communication follows a recent meta-analysis published in the Journal of the American Heart Association ...
University of California - Los Angeles Health Sciences  Jan 18, 2019  5 years ago
UCLA researchers have developed the first technique for turning certain stem cells into mature T cells capable of fighting cancer. The university announced on  January  17th  2019,  that its scientists had developed a technique for coaxing pluripotent stem cells – which can create cell in the body and be grown in a lab – into T cells that can attack tumors. Immun...
Thailand Medical News  Jan 18, 2019  5 years ago
Various research reports on Thailand’s role in the production, local dissemination and exportation to domestic as well as international markets for medical devices reveal healthy forecasts. Predications are that the medical device market in the country  will continue to grow at average rates of between 8.5-10% per annum. Such strength in growth opens exciting opportunities for the Me...
Source: Washington University School of Medicine , St. Louis   Jan 18, 2019  5 years ago
Scientists working to develop more effective treatments for diabetes are turning to stem cells. Such cells can be transformed into cells that produce insulin, the hormone that controls blood sugar. Researchers at Washington University School of Medicine in St. Louis have tweaked the recipe for coaxing human stem cells into insulin-secreting beta cells and shown that the resulting cells are more ...
Source: NYU Langone Health / NYU School of Medicine  Jan 17, 2019  5 years ago
A new class of engineered proteins may counter infection caused by Staphylococcus aureus -- a bacterial species considered one of the largest global health threats, a new study suggests. Published online Jan. 16 in Science Translational Medicine, the study is the result of a five-year research partnership between scientists at NYU School of Medicine and Janssen Research & Dev...
Source: Hong Kong University  Jan 16, 2019  5 years ago
The world has been repeatedly plagued by infectious disease outbreaks, including SARS and MERS coronaviruses, avian influenza viruses, and Zika virus. A team at the Medical Faculty of The University of Hong Kong (HKUMed) led by Professor Yuen Kwok-yung and Dr Shuofeng Yuan of the Department of Microbiology, has discovered a novel broad-spectrum antiviral drug that would be strategic for epidemic c...
Thailand Medical News  Jan 16, 2019  5 years ago
The bacterium Mycoplasma genitalium (MG) is sexually transmitted and can cause inflammation of the urinary and genital tracts in men and women. This germ may also be linked to other problems, including some cases of arthritis and, in women, pelvic inflammatory disease and infertility. MG appears to be spread by unprotected anal or vaginal intercourse, as it can be detected in fluid s...
Source: PLOS  Jan 15, 2019  5 years ago
A practical resource-based public health approach for the rapid initiation of antiretroviral therapy in HIV-infected individuals living in low- and middle-income countries could save thousands of lives, according to an Essay published January 15 in the open-access journal PLOS Medicine by Mark Tenforde of the University of Washington School of Medicine, and colleagues. Effective antir...
Source: Ontario Institute for Cancer Research  Jan 15, 2019  5 years ago
Researchers at the University of Toronto have discovered mutational signatures of tumor hypoxia (low oxygen) in 19 cancer types. The results could be used to help clinicians identify patients who would benefit from higher treatment doses.   In a landmark pan-cancer study analyzing more than 8,000 tumors across 19 different cancer types, researchers have identified molecular hallmarks of...
Source: Krembil Research Institute  Jan 15, 2019  5 years ago
Scientists at the Krembil Research Institute have developed a novel therapeutic treatment that has the potential to stop knee and spine osteoarthritis in its tracks. A team led by Principal Investigator Dr. Mohit Kapoor, Arthritis Research Director at UHN, published the results today in Annals of the Rheumatic Diseases in a paper titled "microRNA-181a-5p antisense oligonucleotide...
Source: Hyogo College of Medicine, Japan  Jan 15, 2019  5 years ago
In a recent study conducted by Professor Dr. Tadayuki Oshima and Professor Dr. Eitatsu Arai from Hyogo College of Medicine, in Japan , demonstrated that the potassium-competitive acid blocker (P-CAB) vonoprazan demonstrates superior efficacy in the treatment of patients with erosive oesophagitis compared with the proton pump inhibitor (PPI) lansoprazole, with the results of a small ...
Source: Newcastle University  Jan 14, 2019  5 years ago
There is little benefit for those over 70 taking higher dose vitamin D supplements to improve their bone strength and reduce the risk of falls, new research has revealed. Older people are often encouraged to take supplements of vitamin D to keep bones, teeth and muscles healthy. But a Newcastle University-led study, published in the American Journal of Clinical Nutrition, has backed previous...
Source: Thailand Medical News  Jan 14, 2019  5 years ago
There are many convincing reasons why expats living in Thailand must take advantage of the country’s healthcare systems. As well as looking at the real benefits to be seen if an individual ever needs to avail of the country’s world-class hospitals, we, at Thailand Medical News will also touch on the more practical matters at local healthcare level. There is a local clinic near you! ...
Author : Mitchel.L .Zoler, MDedge News  Jan 14, 2019  5 years ago
AHA 2019 CONFERENCE COVERAGE   REPORTING FROM THE AHA SCIENTIFIC SESSIONS CHICAGO – When the first results from a large trial that showed profound and unexpected benefits for preventing heart failure hospitalizations associated with use of the antihyperglycemic sodium-glucose cotransporter 2 (SGLT2) inhibitor empagliflozin came out – a little over 3 years ago – the gen...
Source: North American Menopause Society (NAMS).  Jan 14, 2019  5 years ago
There is an ongoing debate regarding the relationship between knee osteoarthritis and hormone therapy (HT), with small-scale studies providing mixed results. A new large-scale study from Korea shows that women receiving HT had a significantly lower prevalence of symptomatic knee osteoarthritis compared with women who did not take hormones. Study results are published online in Menopause, the ...
Source: Bruin Biometrics  Jan 13, 2019  5 years ago
Pressure ulcers are a common malady for bedridden patients, a situation that clinicians have been struggling to improve significantly. There are devices that  sense how long a part of a body has been pressed on for too long, beds that deflate and inflate different areas to provide temporary respite, and clinical routines that help to prevent pressure ulcers. Bruin Biometrics, a compa...
Source: US FDA  Jan 13, 2019  5 years ago
The U.S. Food and Drug Administration today approved Ultomiris (ravulizumab) injection for the treatment of adult patients with paroxysmal nocturnal hemoglobinuria (PNH), a rare and life-threatening blood disease. “The approval of Ultomiris will change the way that patients with PNH are treated,” said Richard Pazdur, M.D., director of the FDA’s Oncology Center of Excellence and...
Source: Massachusetts General Hospital  Jan 13, 2019  5 years ago
A study from a Massachusetts General Hospital (MGH) research team has identified the specific function of a protein found in HIV and related viruses that appears to slow down viral spread in the earliest stages of infection. But they also found that, after initially slowing down the spread of infection, that function may help the virus survive later on by evading the immune response. Their report ...
Source: VIB (the Flanders Institute for Biotechnology)  Jan 13, 2019  5 years ago
Spondyloarthritis is one of the most common types of chronic joint inflammation affecting nearly 1-2% of the Western population. Cytokine blockade of Tumor necrosis factor (TNF) and more recently Interleukin-17 (IL-17) has revolutionized the perspectives of patients suffering from this disease by achieving high levels of therapeutic efficacy. The disease differs substantially from rheumatoid arthr...
Source: University of Texas MD Anderson Cancer Center  Jan 12, 2019  5 years ago
Researchers have identified a new potential immunotherapy target in pancreatic cancer, which so far has been notoriously resistant to treatment with immune checkpoint blockade drugs effective against a variety of other cancers. The University of Texas MD Anderson Cancer Center research team found overexpression of the immune checkpoint VISTA on immune cells, especially macrophages, that infiltr...
Source: VIB (the Flanders Institute for Biotechnology)  Jan 12, 2019  5 years ago
Alzheimer's-affected brains are riddled with so-called amyloid plaques: protein aggregates consisting mainly of amyloid-β. However, this amyloid-β is a fragment produced from a precursor protein whose normal function has remained enigmatic for decades. A team of scientists at VIB and KU Leuven led by professors Joris de Wit and Bart De Strooper has now uncovered that this amyloid pre...
Source: Loyola University Health System  Jan 12, 2019  5 years ago
A landmark study co-authored by a Loyola Medicine oncologist has found that a newer targeted drug is significantly more effective than standard therapy for treating elderly patients with chronic lymphocytic leukemia (CLL). The drug, ibrutinib, attacks cancer cells without damaging normal cells, thus causing fewer side effects. The drug is taken as a pill once a day -- much more convenient than ...
Source: University Of Basel  Jan 11, 2019  5 years ago
The most deadly aspect of breast cancer is metastasis. It spreads cancer cells throughout the body. Researchers at the University and the University Hospital of Basel have now discovered a substance that suppresses the formation of metastases. In the journal Cell, the team of molecular biologists, computational biologists, and clinicians reports on their interdisciplinary approach. The ima...
Source: University of Louisville  Jan 10, 2019  5 years ago
Scientists at the University of Louisville have shown that a microbial metabolite, Urolithin A, derived from a compound found in berries and pomegranates, can reduce and protect against inflammatory bowel disease (IBD). Millions of people worldwide suffer from IBD in the form of either ulcerative colitis or Crohn's disease, and few effective long-term treatments are available. Illustration s...
Source: National Multiple Sclerosis Society  Jan 10, 2019  5 years ago
An immune system drug may help prevent or slow complications in a type of multiple sclerosis known as secondary progressive MS, a new study finds. The medication is called rituximab (Rituxan). It's used to treat a number of conditions, including certain blood cell cancers and the autoimmune condition rheumatoid arthritis. The new Swiss study found that MS patients taking the drug reported ...
Source: Johns Hopkins University School of Medicine  Jan 10, 2019  5 years ago
New research from Johns Hopkins Medicine and Sheppard Pratt Health System shows that people in the study with schizophrenia also have higher levels of antibodies against the Epstein-Barr virus (EBV), a herpes virus that causes infectious mononucleosis, so-called mono. Researchers proposed two explanations for the association of heightened immune responses in patients with schizophrenia and EBV in...
Source: Arizona State University  Jan 09, 2019  5 years ago
In a new study, researchers at the Biodesign Institute explore a safe and simple treatment for one of the most devastating and perplexing afflictions: Alzheimer's disease (AD).   Lead authors Ramon Velazquez and Salvatore Oddo, along with their colleagues in the ASU-Banner Neurodegenerative Disease Research Center (NDRC), investigate the effects of choline, an important nutrient that ma...
Source: Rutgers Robert Wood Johnson Medical School.  Jan 08, 2019  5 years ago
Women with chronic pain or discomfort around the vulva showed improved sexual function with an oral nerve pain medication used to treat pain caused by a previous herpes infection as well as fibromyalgia, according to a Rutgers study.   The study, which was the first to analyze sexual function in women with vulva pain treated with Gabapentin, appeared in the American Journal of Obstetri...