Nikhil Prasad Fact checked by:Thailand Medical News Team Mar 05, 2024 1 month, 3 weeks, 21 hours, 23 minutes ago
COVID-19 News: The current COVID-19 pandemic has prompted widespread vaccination efforts, particularly with mRNA vaccines such as Pfizer and Moderna. While health authorities, politicians linked to the big pharma and and certain groups of researchers receiving monies from big Pharma directly or indirectly from pharmaceutical companies claim that these vaccines have proven highly effective against the SARS-CoV-2 virus, emerging reports raise concerns about their potential to induce or exacerbate autoimmune conditions, notably Systemic Lupus Erythematosus (SLE). This
COVID-19 News report delves into the intricate interplay between COVID-19 mRNA vaccines and SLE, exploring the underlying mechanisms, clinical observations, and the implications for both patients and healthcare professionals.
COVID-19 mRNA Jabs Can Trigger New Onset Of Systemic Lupus Erythematosus
Understanding Systemic Lupus Erythematosus (SLE)
Systemic lupus erythematosus is a complex autoimmune disease wherein the immune system mistakenly attacks its own tissues, leading to inflammation and damage in various organs. This condition can affect joints, skin, brain, lungs, kidneys, and blood vessels. SLE is diagnosed based on clinical symptoms, the presence of antinuclear antibodies (ANA), and the production of immunological complexes. While it is more prevalent among reproductive-age, nonwhite women, it can manifest at any age, gender, or ethnic background, influenced by a combination of genetic and environmental factors.
The seriousness of SLE can range from mild to life-threatening. The disease should be treated by a doctor or a team of doctors who specialize in care of SLE patients. Typically, infections with systemic lupus erythematosus affect the quality of life(QOL) of an individual with substantial reductions.
Association Between COVID-19 and Autoimmune Flares
Studies have highlighted a potential link between COVID-19 infection and autoimmune flares, including SLE. Notably, COVID-19 vaccination has also been implicated in triggering flares of existing autoimmune diseases and raising concerns about the development of new-onset immune-mediated inflammatory diseases (IMIDs). These concerns encompass conditions like myasthenia gravis, sarcoidosis, immune thrombotic thrombocytopenia, autoimmune liver disease, rheumatoid arthritis, and SLE.
Case Studies and Considerations
Examining individual cases, it is suggested that mRNA vaccines may disrupt the immune balance, causing previously asymptomatic diseases like SLE to flare. The need for continued treatment post-vaccination indicates a potential long-term impact, necessitating chronic therapy.
Some Pubslished Case Studies Showing New Onset Of Systemic Lupus Erythematosus (SLE) after COVID-19 mRNA Vaccines:
https://link.springer.com/article/10.1007/s00296-022-05203-3
inkinghub.elsevier.com/retrieve/pii/S2352512622004416">https://linkinghub.elsevier.com/retrieve/pii/S2352512622004416
https://www.hindawi.com/journals/crirh/2022/6436839/
https://pesquisa.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/pt/covidwho-1868417
https://www.mayoclinicproceedings.org/article/S0025-6196(22)00260-9/fulltext
https://bmcrheumatol.biomedcentral.com/articles/10.1186/s41927-022-00313-8
https://academic.oup.com/mrcr/article/8/1/63/7205224
https://www.kidney-international.org/article/S0085-2538(21)00869-3/fulltext
https://jnephropharmacology.com/Article/npj-10564
https://www.hindawi.com/journals/crirh/2022/9698138/
https://www.sciencedirect.com/science/article/pii/S1699258X22001553
https://onlinelibrary.wiley.com/doi/10.1111/jdv.19513
https://eurjrheumatol.org//en/systemic-lupus-erythematosus-following-covid-19-vaccination-133482
https://journals.sagepub.com/doi/10.1177/09612033241232054
https://www.reumatologiaclinica.org/en-systemic-lupus-erythematosus-myocarditis-after-articulo-S1699258X22001553
https://www.cureus.com/articles/82019-covid-19-vaccination-as-a-potential-trigger-for-new-onset-systemic-lupus-erythematosus#!/
https://academic.oup.com/qjmed/article/114/12/882/6427646
https://www.jaadcasereports.org/article/S2352-5126(23)00025-5/fulltext
https://www.gavinpublishers.com/article/view/severe-systemic-lupus-erythematosus-in-a-young--man-following-mrna-covid-19-vaccinations-a-case-report
https://www.springermedizin.de/covid-19/new-onset-systemic-lupus-erythematosus-following-bnt162b2-mrna-c/23481360
Please note that there many more online and also note that many clinical cases are not often published.
Mechanisms of Vaccine-Induced SLE
Several proposed mechanisms may explain the onset or exacerbation of SLE following COVID-19 vaccination. Molecular mimicry, interferon-gamma production via toll-like receptor stimulation, mRNA-induced alteration of post-translational transcription of proteins, and vaccine adjuvants triggering inflammasomes are among the hypothesized pathways. The level of immunogenicity of the administered vaccine may correlate with the rate of autoimmune disease flares, with highly immunogenic vaccines potentially leading to immune dysregulation and subsequent flares.
Exploring the mechanisms of COVID-19 vaccine-induced SLE reveals intriguing insights. Molecular mimicry, where antibodies produced in response to the vaccine cross-react with host proteins, is a proposed mechanism. The mRNA itself, liposomes, or lipid nanoparticles used to encapsulate mRNA, and receptor binding essential for spike protein translation trigger pro-inflammatory pathways. Toll-like receptor (TLR-7) ligand characteristics of single-stranded RNA in mRNA vaccines may interact with the overexpressed TLR-7 in SLE patients, contributing to immune dysregulation. Additionally, increased synthesis of type 1 interferons, essential for SARS-CoV-2 immunity, has been linked to the pathogenesis of SLE.
Clinical Observations and Temporal Associations
Reports indicate that the onset of SLE symptoms following COVID-19 vaccination occurred between 2 to 14 days after the first dose and around 2 weeks following the second dose. Notably, symptom severity increased following the second dose, suggesting a potential correlation between increased immune response and autoimmune exacerbations. This raises concerns about the implications of booster shots in inducing similar reactions.
Preventive Measures and Recommendations
In the context of these potential risks, it is crucial for physicians to be aware of the likelihood of exacerbations of existing autoimmune disorders or the unmasking of de novo autoimmune diseases in predisposed individuals following COVID-19 vaccination. Vigilant monitoring, corticosteroid use, and the full dosage of hydroxychloroquine are suggested precautionary measures to decrease the risk of SLE following vaccination.
Conclusion
In conclusion, the complex relationship between COVID-19 mRNA vaccines and SLE raises important questions about the potential for immune dysregulation and autoimmune reactions. While the claimed benefits of vaccination in preventing COVID-19 are disputable, healthcare professionals must be vigilant and consider the possibility of autoimmune exacerbations. Ongoing research will provide more insights into the immunogenic influence of COVID-19 vaccines and their association with SLE, guiding clinicians in making informed decisions for their patients.
For the latest on the
COVID-19 News, keep on logging to Thailand Medical News.
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