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Nikhil Prasad  Fact checked by:Thailand Medical News Team Feb 06, 2024  3 weeks, 3 days, 2 hours, 19 minutes ago

BREAKING! International Study Warns That Pfizer’s mRNA Vaccines Could Be Causing A Silent Pandemic Of Liver Injury!

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BREAKING! International Study Warns That Pfizer’s mRNA Vaccines Could Be Causing A Silent Pandemic Of Liver Injury!
Nikhil Prasad  Fact checked by:Thailand Medical News Team Feb 06, 2024  3 weeks, 3 days, 2 hours, 19 minutes ago
COVID-19 News: The global fight against the COVID-19 pandemic has witnessed an unprecedented deployment of vaccines, with millions of individuals receiving their shots in an effort to curb the spread of the virus. Among the vaccines administered, the Pfizer-BioNTech COVID-19 mRNA vaccine has emerged as a front-runner. However, a recent international study involving more than 50 prestigious medical and research institutions from around the world has brought to light a concerning revelation - a significant number of individuals who received the Pfizer vaccine developed liver injuries, with many remaining unaware of the impact until reaching an advanced stage.

International Study Warns That Pfizer’s mRNA Vaccines Could Be Causing A Silent Pandemic Of Liver Injury
Already a number of case studies and COVID-19 News reports have warned about Post COVID-19 mRNA Vaccination induced Liver Injury through a variety of mechanisms including the trigger of autoimmune hepatitis.
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(Note that there are many more cases studies and studies online concerning the Pfizer mRNA vaccine and liver injury and we could not list all of them here.)
While many were merely single case studies and cases isolated from published literature meta-analysis, this new study highlighted the growing number of liver injuries and liver damage more so after the Pfizer COVID-19 mRNA vaccines. One of the cases in study eventually died from fulminant liver failure!
The Study: Unraveling Liver Injury Post SARS-CoV-2 Vaccination
The study, titled "Liver injury after SARS‐CoV‐2 vaccination: Features of immune‐mediated hepatitis, role of corticosteroid therapy, and outcome," delves into the clinical features, treatment responses, and outcomes of liver injuries following SARS-CoV-2 vaccination, specifically focusing on a large case series spanning 18 countries.
Demographics and Presentation
The study identified a total of 87 patients, of whom 63% were female, with a median age of 48 years at presentation. Strikingly, liver injury was diagnosed a median of 15 days after vaccination, emphasizing the delayed onset of symptoms. The cases were attributed to various vaccines, with 59% linked to the Pfizer-BioNTech (BNT162b2) vaccine, 23% to the Oxford-AstraZeneca (ChAdOX1 nCoV-19) vaccine, and 18% to the Moderna (mRNA-1273) vaccine.
Characteristics of Liver Injury
The predominant type of liver injury observed was hepatocellular (84%), indicating damage to the liver cells. Notably, 57% of patients exhibited features suggestive of immune-mediated hepatitis, characterized by positive autoantibodies and elevated immunoglobulin G levels.
Corticosteroid Therapy and Treatment Response
Corticosteroids, a class of anti-inflammatory medications, were administered to 53% of patients. The decision to use corticosteroids was influenced by the severity of liver injury, with a higher percentage (88.9%) receiving therapy for grade 3–4 liver injury compared to grade 1–2 liver injury (43.5%). Moreover, patients with immune-mediated hepatitis were more likely to receive corticosteroids (71.1%) compared to those without (38.2%).
Outcomes and Prognosis
Encouragingly, the study reported a generally favorable outcome for the majority of patients, as all cases demonstrated resolution of liver injury. However, one patient (1.1%) experienced fulminant liver failure, necessitating liver transplantation. The withdrawal of steroid therapy, after complete biochemical resolution, occurred in 26% of patients during the observation period, and notably, none experienced a relapse during follow-up.
(please note that in the study because of constant surveillance of the liver injuries and immediate treatments accorded by the researchers, many had good outcomes. However, in the real world, many are not even aware that they have liver injury till the condition progresses to an advance stage!
Conclusion: Unraveling the Complexities of SARS-CoV-2 Vaccination and Liver Health
In conclusion, the study sheds light on a previously underexplored aspect of SARS-CoV-2 vaccination - the potential association with liver injury. While the majority of cases exhibited positive outcomes, the findings underscore the importance of recognizing and addressing the risk of liver injury post-vaccination. Corticosteroid therapy emerged as a potential intervention for those with severe hepatitis or immune-mediated features, providing a crucial avenue for treatment.
As the global vaccination campaign continues, this study serves as a crucial reminder for healthcare professionals to remain vigilant about potential adverse effects, ensuring comprehensive monitoring and timely interventions. Public awareness campaigns may also play a pivotal role in educating individuals about the signs and symptoms of liver injury, empowering them to seek medical attention promptly.
Ultimately, the journey towards defeating the COVID-19 pandemic necessitates a nuanced understanding of the potential risks associated with vaccination. Through ongoing research and vigilant surveillance, the medical community can continue to refine vaccination strategies, ensuring the safety and well-being of individuals worldwide.
The study findings were published in the peer reviewed journal: Hepatology.
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