BREAKING News! Gene Study Reveals How COVID-19 mRNA Vaccine Leads To High Risk Of IgA Nephropathy, Eventual Kidney Failure And Possible Cancers!
Nikhil Prasad Fact checked by:Thailand Medical News Team Feb 03, 2024 2 months, 3 weeks, 3 days, 6 hours, 14 minutes ago
COVID-19 News: The relentless battle against the COVID-19 pandemic has witnessed the unprecedented development and deployment of mRNA-based vaccines, offering a ray of hope in the global effort to curb the spread of the virus.
Many Are Not Even Aware That COVID-19 mRNA Causes IgA Nephropathy
However, a groundbreaking gene study has recently surfaced, raising concerns about a potential link between COVID-19 mRNA vaccination and the emergence of IgA nephropathy (IgAN) - a renal disorder with far-reaching consequences. In this
COVID-19 News report, we embark on an in-depth exploration of the study conducted by researchers from Henan Provincial People's Hospital and People's Hospital of Zhengzhou University-China and The First Affiliated Hospital of Zhengzhou University-China.
Deciphering IgA Nephropathy
IgA nephropathy stands as a formidable renal disease, characterized by the accumulation of Immunoglobulin A (IgA) protein within the kidney's glomerulus, the crucial filtering unit. Though often presenting with minimal symptoms, the telltale sign is blood in the urine,(which is typically not visible by the eye but detected via urine analysis) highlighting the potential damage to the renal system. Regrettably, this condition stands as a leading cause of chronic kidney disease (CKD) and eventual kidney failure on a global scale, significantly diminishing life expectancy for those affected. Despite the ongoing research, a definitive cure for IgA nephropathy remains elusive, with current treatment options aiming to decelerate disease progression and alleviate symptoms.
The worse part of this condition is that many people are unaware that their kidney are being damaged and the condition progresses over months or years before it is detected at a stage when the situation is bad.
The Unsettling Connection: COVID-19 mRNA Vaccination and IgAN
Numerous cases reports and studies have validated the development of IgA Nephropathy especially after the second dose of the mRNA COVID-19 vaccines by Pfizer or Moderna.
https://www.kireports.org/article/S2468-0249(21)01448-0/fulltext
https://journals.lww.com/kidney360/fulltext/2021/11000/glomerular_disease_in_temporal_association_with.13.aspx
https://link.springer.com/article/10.1007/s10157-021-02157-x
https://academic.oup.com/qjmed/article/116/1/26/6654600
https://link.springer.com/article/10.1007/s13730-021-00679-7
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https://www.jstage.jst.go.jp/article/internalmedicine/61/7/61_8787-21/_article
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468727/
https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-022-02769-9
https://pubmed.ncbi.nlm.nih.gov/35470996/
https://pubmed.ncbi.nlm.nih.gov/35498904/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388006/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266892/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348063/
https://journals.sagepub.com/doi/10.1177/03000605221129674
https://pubmed.ncbi.nlm.nih.gov/34534551/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214418/
https://pubmed.ncbi.nlm.nih.gov/36262058/
https://pubmed.ncbi.nlm.nih.gov/37332909/
The aforementioned study in China, accessible on the National Center for Biotechnology Information (NCBI) platform, undertook a comprehensive investigation into the molecular mechanisms interlinking COVID-19 mRNA vaccination and IgA nephropathy. Leveraging gene expression datasets related to both phenomena, the researchers deployed Weighted Gene Co-Expression Network Analysis (WGCNA) to pinpoint shared co-expression modules and unravel potential molecular pathways.
Key Revelations from the Study
WGCNA yielded fascinating insights, highlighting a specific module significantly associated with the administration of the second dose of the COVID-19 mRNA vaccine. Intriguingly, four modules were identified as closely associated with IgA nephropathy. Gene Ontology (GO) analyses of these modules illuminated cell cycle-related processes for COVID-19 mRNA vaccine hub genes and immune effector processes for IgAN hub genes.
Delving deeper into the genomic landscape, the study unearthed 74 differentially expressed genes for the COVID-19 mRNA vaccine and a substantial 574 differentially expressed genes for IgAN. Remarkably, through intersection analysis, two pivotal genes emerged - TOP2A and CEP55 - sharing a common ground between COVID-19 mRNA vaccination and IgA nephropathy.
An In-Depth Look at TOP2A and CEP55
The study honed in on DNA topoisomerase II alpha (TOP2A) and centrosomal protein 55 (CEP55) as the central hub genes.
TOP2A, renowned for its role in facilitating the passage of double-stranded DNA through transient breaks, exhibited an intriguing upregulation in individuals who received the second dose of the COVID-19 mRNA vaccine. This gene is also associated with kidney cancer!
This finding opens a window into a potential likeness between the live virus and the vaccine's spike protein, warranting further investigation.
On the other hand, CEP55, a key player in cell division, manifested specific expression patterns in various cancers but not in normal cells. The study postulated its potential significance in both IgAN and COVID-19 vaccination, suggesting its involvement in the NF-KB pathway. Notably, this pathway serves as a predictive factor for a poor prognosis in IgAN patients, raising questions about the multifaceted role of CEP55 in the context of nephropathy.
Addressing Limitations and Charting Future Directions
While the study offers a profound understanding of potential molecular links, it acknowledges certain limitations. The importance of biological verification and the validation of gene expression in peripheral blood mononuclear cells (PBMCs) and kidney sections is underscored. The authors stress the necessity of collecting blood samples from individuals who developed IgA nephropathy post the second dose of the COVID-19 vaccine, emphasizing the critical need for further validation.
Conclusion
In conclusion, this comprehensive exploration sheds light on a potential molecular connection between COVID-19 mRNA vaccination and the emergence of IgA nephropathy. The identification of hub genes, TOP2A and CEP55, provides a launching pad for deeper investigations into the shared molecular mechanisms. As the global fight against COVID-19 persists, understanding these intricate interactions becomes paramount for refining vaccination strategies and ensuring the safety of individuals receiving mRNA-based vaccines. The study serves as a cornerstone in unraveling the complex interplay between immunization and renal health, urging continued research and vigilance in the pursuit of a safer and more effective vaccination approach.
The study findings were published in the peer reviewed journal: Kidney and Blood Pressure Research (Karger).
https://karger.com/kbr/article/doi/10.1159/000535626/894924/Molecular-Pathogenic-Mechanisms-of-IgA-Nephropathy
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