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Nikhil Prasad  Fact checked by:Thailand Medical News Team Jan 08, 2024  1 month, 2 weeks, 2 days, 20 hours, 28 minutes ago

Medical News: UK Study Finds That Carnosine Could Be Used To Treat Prostate Cancer

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Medical News: UK Study Finds That Carnosine Could Be Used To Treat Prostate Cancer
Nikhil Prasad  Fact checked by:Thailand Medical News Team Jan 08, 2024  1 month, 2 weeks, 2 days, 20 hours, 28 minutes ago
Medical News: Prostate cancer, a pervasive and formidable adversary among men, necessitates innovative and targeted treatment strategies to improve patient outcomes while minimizing treatment-related side effects. A recent study conducted by scientists at Nottingham Trent University that is covered in this Medical News report, has found a potential game-changer in the realm of prostate cancer treatment - carnosine. This naturally occurring dipeptide, synthesized in the human body and found in certain meats, has long been recognized for its antioxidant properties. However, this study marks the first comprehensive exploration of carnosine's efficacy against both primary and metastatic prostate cancer cells, offering a glimmer of hope for more effective and less invasive treatment options.


Carnosine Can Be Used To Treat Prostate Cancer As A First Line Drug
 
Understanding Carnosine's Origins and Function
Carnosine, composed of β-alanine and L-histidine, is a dipeptide abundantly present in the brain, muscle, and gastrointestinal tissues. Its synthesis occurs within the human body, and it can be obtained from dietary sources such as turkey, chicken, beef, or pork. The concentration of carnosine in muscle tissue is directly correlated with muscle strength, making it a crucial component for overall muscle health.
 
While carnosine has been lauded for its antioxidant properties, serving as a defense against oxidative stress and supporting healthy aging, its potential anti-cancer properties have only recently come under scientific scrutiny. The UK study aimed to investigate the effects of carnosine on both primary cultured androgen-resistant human prostate cancer cells (PC346Flu1) and murine prostate cancer cells (TRAMP-C1). Results demonstrated a significant dose-dependent inhibitory effect on the proliferation of these cancer cells, with higher doses even inducing cell death. Importantly, this inhibitory impact was observed while maintaining the safety of healthy non-dividing cells, emphasizing carnosine's potential as a targeted therapy.
 
Prostate Cancer - A Looming Health Concern
Prostate cancer stands as the most common cancer diagnosed in men in the UK, affecting more than 52,000 individuals annually. The disease's prevalence highlights the urgent need for effective treatments that not only target cancer cells but also minimize side effects and improve patients' quality of life. Current treatment options, including prostatectomy, radiation therapy, chemotherapy, and hormone deprivation therapy, often come with significant drawbacks such as urinary incontinence and erectile dysfunction.
 
The Novel Approach - Carnosine's Impact on Prostate Cancer Cells
The research involved studying carnosine's effects on both primary cultured androgen-resistant human prostate cancer cells (PC346Flu1) and murine prostate cancer cells (TRAMP-C1). Results demonstrated a significant d ose-dependent inhibitory effect on the proliferation of these cancer cells, with higher doses even inducing cell death. Importantly, this inhibitory impact was observed while maintaining the safety of healthy non-dividing cells, emphasizing carnosine's potential as a targeted therapy.
 
Mechanisms Unveiled - How Carnosine Works Against Prostate Cancer
To comprehend the potential of carnosine in prostate cancer treatment, the researchers delved into its mechanisms of action. Carnosine treatment led to a reduction in reactive species (RS) levels and an increase in SIRT3 expression. SIRT3, identified as a key regulator of RS and oxygen metabolism balance, exhibited significant upregulation after exposure to carnosine.
 
This upregulation of SIRT3 suggests a potential multifaceted approach to combating prostate cancer. Beyond directly scavenging free radicals, carnosine's ability to enhance SIRT3 expression could contribute to preventing the spread of localized prostate cancer, showcasing its broader anti-cancer potential.
 
Visual Confirmation - Live-Cell Imaging
Live-cell imaging further supported the findings by demonstrating a dose-dependent decrease in live cell numbers and an increase in the number of dying cells upon carnosine treatment. This visual confirmation reinforces the potential therapeutic benefits of carnosine against prostate cancer cells, marking a significant step forward in the understanding of its practical impact.
 
Clinical Implications and Future Directions
The implications of carnosine's anti-cancer properties are particularly significant for prostate cancer treatment. The study proposes two potential approaches for utilizing carnosine effectively. One involves a slow-release mechanism, such as injecting carnosine directly into the tumor, ensuring a sustained therapeutic effect. The second approach suggests using carnosine-like molecules resistant to enzymatic degradation, opening avenues for novel drug development.
 
Monitoring tumor growth through prostate-specific antigen (PSA) levels in the blood emerges as a crucial aspect of this proposed treatment strategy. If tumor growth persists, patients could opt for surgery, a decision that would be more informed and potentially less complicated due to reduced scarring caused by carnosine treatment.
 
The prospect of carnosine as an adjunct therapy or even a standalone treatment offers hope for minimizing side effects and improving outcomes for prostate cancer patients. Lead researcher Dr. Stephanie McArdle emphasizes the need for further human in vivo work to determine carnosine's full potential in prostate cancer treatment.
 
Beyond the Lab - The Broader Implications
Carnosine's journey from being recognized as an antioxidant to a potential anti-cancer agent underscores the importance of continued research and clinical exploration in the pursuit of innovative solutions for combating prostate cancer. As the scientific community anticipates the next chapter in carnosine research, the potential for transforming the landscape of prostate cancer treatment remains on the horizon, promising a brighter and more targeted future for patients facing this challenging diagnosis.
 
The study's findings not only present a potential breakthrough in prostate cancer treatment but also open doors for further exploration into the broader applications of carnosine. Its minimal side effects and multifaceted mechanisms make it a compelling candidate for further investigations in various cancer types.
 
Challenges and Considerations
While the study's results are promising, it's essential to acknowledge the complexities of translating laboratory findings to clinical applications. The transition from bench to bedside involves rigorous testing, including preclinical trials and eventually human clinical trials, to ensure safety and efficacy.

Moreover, the potential variations in individual responses to carnosine treatment underscore the need for personalized medicine approaches. Factors such as genetic makeup, lifestyle, and overall health may influence the effectiveness of carnosine as a therapeutic agent.
 
Conclusion
In conclusion, the Nottingham Trent University study unveils a potential breakthrough in prostate cancer treatment through the exploration of carnosine's anti-cancer properties. With its minimal side effects and potential for targeted therapy, carnosine holds promise as a first-line treatment for prostate cancer. As researchers delve deeper into the mechanisms of carnosine's action and its impact on tumor growth, the medical community eagerly awaits further human in vivo studies to solidify carnosine's role in revolutionizing prostate cancer treatment strategies.
 
The prospect of a novel, effective, and less invasive treatment option brings renewed hope for the thousands of men diagnosed with prostate cancer each year. Carnosine's journey from being recognized as an antioxidant to a potential anti-cancer agent underscores the importance of continued research and clinical exploration in the pursuit of innovative solutions for combating prostate cancer. As the scientific community anticipates the next chapter in carnosine research, the potential for transforming the landscape of prostate cancer treatment remains on the horizon, promising a brighter and more targeted future for patients facing this challenging diagnosis.
 
The study findings were published in the peer reviewed Journal of Cellular and Molecular Medicine.
https://onlinelibrary.wiley.com/doi/10.1111/jcmm.18061
 
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