For The Latest Medical News, Health News, Research News, COVID-19 News, Pharma News, Glaucoma News, Diabetes News, Herb News, Phytochemical News, Thailand Cannabis News, Cancer News, Doctor News, Thailand Hospital News, Oral Cancer News, Thailand Doctors

BREAKING NEWS
Staff Writer, TMN  Jul 06, 2018  7 years, 2 months, 3 weeks, 3 days, 17 hours, 45 minutes ago

SMAD4 clue to colon cancer

SMAD4 clue to colon cancer
Staff Writer, TMN  Jul 06, 2018  7 years, 2 months, 3 weeks, 3 days, 17 hours, 45 minutes ago
Chronic inflammation is a predisposing condition for colorectal cancer, the third leading cause of cancer-related deaths in the United States.
Reporting last month in the journal Cellular and Molecular Gastroenterology and Hepatology, Anna Means, Ph.D., and colleagues have now linked inflammation-driven carcinogenesis in the colon to loss of an important signaling protein called SMAD4.
colon cancer

 Molecular basis of colorectacl cancer.


SMAD4 is part of the transforming growth factor beta (TGF-beta) signaling pathway that in the epithelium of the colon regulates the immune/inflammatory response to infection.
 
Specific deletion of the Smad4gene in normal mouse colon epithelial cells grown in vivo increased the expression of inflammatory mediators. In adult mice in the presence of inflammation, deletion resulted in tumors bearing a striking resemblance to human colitis-associated carcinoma.
 
Loss of SMAD4 also was observed in 48 percent of human colitis-associated carcinomas compared with 19 percent of sporadic colorectal carcinomas. "This loss may be an important factor in progression from premalignant lesions to invasive malignancy," the researchers concluded.
 
Reference:   Anna L. Means et al. Epithelial Smad4 Deletion Up-Regulates Inflammation and Promotes Inflammation-Associated Cancer, Cellular and Molecular Gastroenterology and Hepatology (2018). DOI: 10.1016/j.jcmgh.2018.05.006 

MOST READ

Sep 22, 2025  11 days ago
Nikhil Prasad
Sep 17, 2025  16 days ago
Nikhil Prasad
Sep 16, 2025  17 days ago
Nikhil Prasad
Sep 10, 2025  23 days ago
Nikhil Prasad
Sep 06, 2025  27 days ago
Nikhil Prasad
Sep 04, 2025  29 days ago
Nikhil Prasad
Sep 04, 2025  29 days ago
Nikhil Prasad
Aug 20, 2025  1 month ago
Nikhil Prasad
Aug 18, 2025  2 months ago
Nikhil Prasad
Aug 16, 2025  2 months ago
Nikhil Prasad
Aug 12, 2025  2 months ago
Nikhil Prasad
Aug 09, 2025  2 months ago
Nikhil Prasad