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Source: Thailand Medical News  Jan 29, 2020  4 years, 2 months, 2 weeks, 5 days, 17 hours, 20 minutes ago

Cannabidiol From Cannabis Can Help Treat Patients With Psychosis

Cannabidiol From Cannabis Can Help Treat Patients With Psychosis
Source: Thailand Medical News  Jan 29, 2020  4 years, 2 months, 2 weeks, 5 days, 17 hours, 20 minutes ago
Thailand Cannabis News

Medical Researchers from King's College London have shown that cannabidiol (CBD) from cannabis alters the brain activity in people with psychosis during memory tasks, making it more similar to the activation seen in people without psychosis during the same tasks.


 
The new research on medical cannabis was published in Psychological Medicine, the research used fMRI scans to examine the brain activity of 13 people with a diagnosis of psychosis under the influence of a single dose of CBD or placebo and 16 controls whilst they were undertaking a memory task. The researchers showed that, during the task, there was a different pattern of activity in the prefrontal and mediotemporal brain areas of people with psychosis under placebo compared to the activity seen in those without psychosis. When those with psychosis were given one dose of CBD, the activation in these brain areas became more like the activation seen in controls.
 
Professor Dr Sagnik Bhattacharyya, the senior author on the study, from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN), King's College London told Thailand Medical News, "Our study provides important insight into which areas of the brain CBD targets. It is the first time research has scanned the brains of people with a diagnosis of psychosis who have taken CBD and, although the sample is small, the results are compelling in that they demonstrate that CBD influences those very areas of the brain that have been shown to have unusual activity in people with psychosis."
 
Cannabidiol or CBD is one of over 100 chemical compounds known as cannabinoids that are found in the cannabis plant. There has been recent interest in the use of cannabidiol (CBD) as an alternative to current antipsychotic medicines as it could prove to be more tolerable generally and more effective for a subset of people who do not respond to available antipsychotics. Its use has been associated with a decrease in symptoms of psychosis and changes in brain activity during verbal memory tasks in patients at high risk of psychosis.
 
The research study also showed that activity in the striatum and the activity in hippoca mpus was more co-ordinated in people with psychosis, indicating there was a greater functional connectivity between these two areas in this group compared to controls. After one dose of CBD this functional connectivity was reduced in