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The term autoimmunity refers to a failure of the body’s immune system to recognize its own cells and tissues as “self.” Instead, immune responses are launched against these cells and tissues as if they were foreign or invading bodies.
Research conducted by Noel Rose and Witebsky in New York and Roitt and Doniach at University College London showed that diseases such as rheumatoid arthritis and thyrotoxicosis were linked to an inadequate immune tolerance and these conditions were caused by the body’s inability to fight “non-self” substances while also being able to ignore “self” substances.
This lack of immunological tolerance means the immune system mounts an attack against self determinants, through the production of antibodies. These reactive molecules are referred to as autoantibodies. How immunological tolerance develops is not yet understood, but three popular theories among immunologists are described below.
Further theories currently being investigated include the “Clonal Ignorance theory,” and the “Suppressor population or Regulatory T cell theory.” The “Clonal Ignorance theory” suggests that self-reactive T cells not present in the thymus move to the periphery where they fail to encounter target antigens. Self-reactive B cells then fail to find the correct helper T-cell or antigen. The “Suppressor population or Regulatory T cell theory,” holds that regulatory T-lymphocytes such as CD4+FoxP3+ cells prevent, down regulate or reduce aggressive immune responses to self tissues.