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Antibiotic resistance is one of the factors which causes delay in wound healing and a corresponding spike in medical and healthcare expenses.
The primary reason for the emergence of resistance is the inappropriate use of antimicrobials. To use antibiotics wisely, it is necessary to understand the principles of diagnosing wound infection, what organisms are likely to be responsible, and to what antimicrobial agents they respond.
This knowledge will help to ensure that antibiotics are used only when essential, and in a manner that does not cause more resistance to be generated.
Prevention of Inappropriate Antibiotic Use
To prevent the emergence of resistance, the following practices are recommended:
The gravity of antibiotic resistance in wound care is well established, and many wound cultures, especially from chronic wounds caused by vascular insufficiency, show multiple bacterial strains which are resistant to common antibacterials.
In such cases, repeated cultures become a vital tool to monitor the emergence of resistant strains in the community. The wound surgeon, the microbiologist, and other specialists in community medicine must collaborate to get early culture results and use them to select the right antimicrobial therapy.
The change in resistance patterns in the community makes the availability of local epidemiologic studies an important factor in choosing the right empirical therapy.
A common misconception which has led to excessive antibiotic use in chronic non-healing ulcers is the attribution of the slow recovery to bacterial infection, whereas it is the disrupted vascular pattern which is to blame. Thus, avoiding the use of antibiotics in this population of patients is likely to create a significant reduction in antibiotic resistance.
Newer and more effective approaches which focus on removal of the biofilm and encouraging physiological conditions in the wound area will reduce the healing time and the need to resort to antibiotics in this segment.
Prevention of Spread of Existing Resistant Strains
However, other steps need to be taken to isolate the resistant strain and prevent its transmission to others, both patients and staff. These include:
These must be exploited in full measure to keep antibiotic-resistant microbes from spreading inside and beyond the hospital.
Topical antimicrobials, unlike antibiotics, act at multiple sites to inhibit or destroy target cells, and this means that resistance is rare. Thus the use of topical agents to arrest bacterial growth in wounds is an area of immense potential in wound care, reducing bacterial counts without resorting to antibiotics.
The use of topical antibiotics is another option but this requires sound clinical experience and specific wound criteria. For instance, foul-smelling open wounds may benefit from one topical agent while burns may require another type. At the same time, the adverse effects of topical antimicrobials must also be rigorously assessed, as blood dyscrasias have been reported with some commonly used preparations.
Silver, cationic antimicrobials, and quaternary ammonium compounds are all examples of effective skin antiseptics which are proven to be useful in wound care without the need for antibiotic use.
In short, antibiotics should be used to treat bacterial infection only when indicated by appropriate guidelines, and antiseptics should be given increased priority in wound care. This will create antimicrobial barriers while cutting down the bacterial counts in the wound, and reduce the chances of antibiotic resistance as well.