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Cetuximab is a monoclonal antibody that inhibits the epidermal growth factor receptor (EGFR) which is present on the surface of some cancer cells. Cetuximab binds to the receptor, preventing epidermal growth factor (EGF) from binding to it and stimulating growth of the cancer cells.
Cetuximab is approved for use in:
The drug is usually administered at an initial dose of 400 mg per squared meter of surface body area over 120 minutes, followed by a dose of 250 mg per squared meter of body surface area once a week over a 1-hour infusion.