Chromosome 4 Related Diseases

Chromosome 4 is the fourth largest of the 23 pairs of chromosomes in humans. Chromosome 4 spans about 186 million base pairs, the building blocks of DNA, which are tightly packed and supercoiled to form the DNA's helical structure. This chromosome represents around 6% to 6.5% of the DNA in the human genome and contains around 1000 to 1100 genes.

Some of the diseases and conditions linked to chromosome 4 include:

• Achondroplasia and hypochondroplasia, forms of short-limbed dwarfism
• Thanatophoric dysplasia type 1
• Crouzon syndrome with acanthosis nigricans
• Muenke syndrome
• Bladder cancer
• Colorectal cancer or bowel cancer
• Cervical cancer
• LADD syndrome
• CATSHL syndrome
• Skin lesion formation
• Thanatophoric dysplasia type II
• Wolf-Hirschhorn syndrome
• Ellis-van Creveld syndrome
• Weyers acrodental dysostosis
• Stature QTL 13
• Kahrizi syndrome
• Amelogenesis imperfecta, type IB and type IC
• Proximal renal tubular acidosis
• Juvenile hyaline fibromatosis
• Infantile systemic hyalinosis
• Parkinson's disease type 1 and 4
• Lewy body formation
• Dementia
• Beta-mannosidosis
• Systemic lupus erythematosus
• Sebaceous tumors
• Hypomagnesemia
• Familial hypertrophic cardiomyopathy
• Bardet-Biedl syndrome
• Celiac disease
• Autoimmune disease
• Glutaric acidemia type IIC
• Early-onset retinal dystrophy
• Leber congenital amaurosis
• Juvenile retinitis pigmentosa
• Chronic lymphocytic leukemia
• Fibrodysplasia ossificans progessiva
• Haemophilia C
• Huntington's disease
• Hemolytic uremic syndrome
• Hirschprung's disease
• Nonsyndromic deafness
• Ondine's curse
• Polycystic kidney disease
• Romano-Ward syndrome
• Tetrahydrobiopterin deficiency
• Wolfram syndrome