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The EHR-agnostic, clinico-genomic mobile app was developed to demonstrate several features that will be needed for point-of-care conversations. The prototype visualizes genomic information in real time, comparing a patient’s diagnosis-specific somatic gene mutations detected by PCR-based hotspot testing to a population-level set of comparable data. The app can be implemented on any SMART on FHIR-enabled EHR, and future versions should be able to evolve in parallel with external knowledge bases.