Thailand Medical News - For All The Latest Breaking Medical News, Health News, Research News, COVID-19 News, Outbreak News, Dengue News, Glaucoma News, Diabetes News, Herb News, Phytochemical News, Heart And Cardiology News, Epigenetic News, Cancer News,
The occurrence of cholangiocarcinoma is due to changes that take place in the cells of the bile duct in the liver DNA—the material which gives guidance to our body related to all chemical process. The changes in instruction are caused by DNA mutation, due to which the cells start growing uncontrollably and finally form cancer.
The problems arising in the bile duct, which may or may not be due to the manifestation of cancer, such as irritation, inflammation, or any obstruction, cause dilemma in the digestive system or jaundice or lead to chronic diseases and produce parasitic infections.
The definitive cause of cholangiocarcinoma is still unknown. There are, however, cancer suppressor genes, which ultimately cause death of the cells and block cell division. Due to the mutations of DNA, cancer may occur as a result of turning on of oncogenes and turning off of the cancer suppressor genes.
For a cell to turn cancerous there is a need for changes in various genes. In some cancers, the risk factors are increased due to change in DNA by parents. However, most of the bile duct cancers are not caused by inherited gene changes.
Other expected causes of bile duct cancer are:
Other factors such as erythrogenic intestine cancer, diabetes, and virus hepatitis are also thought to cause this type of cancer, but further studies are needed to confirm their exact role.
The factors that increase the risk of cancer are termed as risk factors. Different diseases will have different risk factors. It does not mean that having one or more risk factor will lead to cancer.
As the causes of this cancer still remain unidentified, researchers think that a few risk factors play a vital role in triggering it.
The risk factors include:
In nearly 1 out of 10 people with ulcerative colitis, the complete intestine is infected and consists of primary sclerosing cholangitis.
At present, the specialists are thinking that the risk factor associated with bile duct cancer is PSC rather than ulcerative colitis.