Diabetes And COVID-19: Study Shows That Diabetics With High BMI Usually End Up On Ventilators Or /And Die Within 7 Days Upon Hospital Admission
Diabetes And COVID-19
: French researchers in a new study show that body mass index (BMI) is associated with tracheal intubation and/or death within seven days among individuals with diabetes hospitalized for COVID-19.
Dr Bertrand Cariou from the University of Nantes in France, and his research team conducted a multicenter study in 1,317 people with diabetes (88.5 percent with type 2 diabetes; 64.9 percent men) hospitalized for COVID-19.
The study findings showed that combined tracheal intubation for mechanical ventilation and/or death within seven days of admission was the primary end point.
The research findings were published in the medical journal: Diabetologia.
The medical researchers found that the primary outcome occurred in 29 percent of participants, while 10.6 and 18 percent died and were discharged on day 7, respectively. Characteristics prior to admission that were significantly associated with the primary outcome included sex, BMI, and previous treatment with renin-angiotensin-aldosterone system blockers, but not age, type of diabetes, hemoglobin A1c, diabetic complications, or glucose-lowering therapies in a univariate analysis. Only BMI remained positively associated with the primary outcome in multivariable analyses with covariates prior to admission (odds ratio, 1.28).
Upon admission, independent predictors for the primary outcome included dyspnea, lymphocyte count, C-reactive protein, and aspartate aminotransferase (odds ratios, 2.10, 0.67, 1.93, and 2.23, respectively). Independent associations for the risk for death on day 7 were seen for age, treated obstructive sleep apnea, and microvascular and macrovascular complications (odds ratios, 2.48, 2.80, 2.14, and 2.54, respectively).
Dr Bertrand Cariou told Thailand Medical News, "The CORONADO study refined the phenotypes of COVID-19 individuals with diabetes admitted to hospital and showed that chronic glycemic control did not impact the immediate severity of COVID-19."
Individuals who are obese and are diabetic are urged to exercise more precautions as they are one of the vulnerable groups for the ongoing COVID-19 pandemic.
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