Prednisone: Study Warns That Prednisone Usage Linked With Higher Risk Of Hospitalization and Severity In COVID-19 Patients
According to a new international study involving researchers from America, Europe, Australia and Canada, for patients with rheumatic disease infected with COVID-19, usage of glucocorticoids such as predisone is associated with increased odds of hospitalization and severity.
The study was published in the journal: Annals of Rheumatic Diseases
Dr Milena Gianfrancesco, Ph.D., M.P.H., from the University of California San Francisco, and international colleagues examined demographic and clinical factors associated with COVID-19 hospitalization status in individuals with rheumatic disease using data from March 24 to April 20, 2020. Six hundred cases from 40 countries were included.
The study team found that 46 percent of cases were hospitalized and 9 percent died. Prednisone dose ≥10 mg/day was associated with increased odds of hospitalization in multivariable adjusted models (odds ratio, 2.05; 95 percent confidence interval [CI], 1.06 to 3.96).
However there was no association seen for use of conventional disease-modifying antirheumatic drugs alone or in combination with biologics/Janus Kinase inhibitors (odds ratios, 1.23 [95 percent CI, 0.70 to 2.17] and 0.74 [95 percent CI, 0.37 to 1.46], respectively). There was no association noted for nonsteroidal anti-inflammatory drug use with hospitalization status (odds ratio, 0.64; 95 percent CI, 0.39 to 1.06).
Interestingly, reduced odds of hospitalization were seen in association with tumor necrosis factor inhibitor use (odds ratio, 0.40; 95 percent CI, 0.19 to 0.81), while no link was seen with antimalarial use (odds ratio, 0.94; 95 percent CI, 0.57 to 1.57).
Dr Gianfrancesco told Thailand Medical News, "With additional cases, we will be able to examine more detailed outcomes associated with specific rheumatic diseases and COVID-19 treatments, as well as the outcomes of COVID-19 in people with rheumatic diseases."
Patients currently taking prednisone for rheumatic diseases or other conditions are advised not to stop their medications immediately but rather to consult their physicians for either alternatives or ways to further safeguard themselves.
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