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More than six years after SARS-CoV-2 first emerged, scientists are warning that COVID-19 can leave behind complicated health problems affecting far more than the lungs. A major collection of research on long COVID highlights persistent inflammation, neurological symptoms, fatigue, metabolic changes and possible effects on other chronic diseases.
New research reveals how long COVID may drive l...
MRI Study Finds Brain Changes After COVID-19
A new brain imaging study suggests COVID-19 may be associated with measurable reductions in two important structures: the olfactory bulbs, which process smell, and the hippocampus, which is central to memory and learning.
MRI research links COVID-19 with smaller smell-processing and memory-related brain regions, especially among
patients reporting sme...
A new study from China has found that people who were previously healthy can experience measurable reductions in heart, lung and exercise performance months after SARS-CoV-2 infection, adding to concerns that Long COVID can affect several body systems at the same time.
Long COVID patients showed measurable reductions in exercise capacity, cardiovascular performance and breathing
function mon...
COVID-19 may leave consequences that extend far beyond the lungs, with researchers warning that SARS-CoV-2 infection could disturb bone health from microscopic bone cells all the way to the overall strength of the skeleton. The new scientific review brings together clinical findings, animal experiments, advanced imaging and biomechanical research suggesting that COVID-19-associated bone damage is ...
Scientists are exploring new ways to strengthen the cancer-fighting potential of ferulic acid, a natural plant compound found in cereal grains, fruits and vegetables. A new scientific review suggests that advanced drug-delivery systems and specially designed chemical derivatives could overcome major problems that have prevented the compound from progressing toward clinical cancer treatment.
N...
Researchers Find Measurable Changes in Long COVID Brains
Scientists have identified two unusual brainwave patterns that may help explain fatigue and “brain fog” in Long COVID. The findings raise the possibility that electroencephalography, or EEG, could help assess difficult-to-measure neurological symptoms.
Altered beta and alpha brainwaves were linked to brain fog and fatigue i...
Thai Researchers Investigate a Traditional Edible Plant
A new study from Thailand has found that an aqueous extract of Piper sarmentosum Roxb. may help improve cholesterol levels, reduce signs of liver stress and reshape gut bacteria disturbed by a high-fat diet.
Thai researchers found that Piper sarmentosum extract improved cholesterol and liver markers while altering gut
microbiome patter...
A striking medical case involving a 55-year-old woman with COVID-19 myocarditis, severe heart dysfunction and worsening kidney injury suggests that COVID-19 may directly or indirectly create conditions capable of triggering a dangerous complication known as BRASH syndrome.
COVID-19-associated myocarditis and worsening kidney dysfunction may create conditions that help trigger
the potentially...
Popular Antioxidant Supplement Comes Under Scrutiny
Alpha-lipoic acid (ALA), a widely available antioxidant supplement, may trigger a rare but potentially dangerous condition called insulin autoimmune syndrome (IAS) in genetically susceptible people, according to a new scientific review and clinical case analysis.
Researchers warn that alpha-lipoic acid supplements may trigger a rare insulin...
A new study has identified a troubling biological pathway that could explain why some people experience persistent joint, cartilage and bone problems after COVID-19. Researchers found that a small signaling peptide called endothelin-1 (ET-1) may help transmit damaging effects from SARS-CoV-2-injured lungs to distant skeletal tissues.
Researchers have identified endothelin-1 as a possible link...
The blue light produced by digital screens may do more than cause temporary eye discomfort. New laboratory research suggests prolonged blue-light exposure can activate a destructive form of cell death in the cornea, potentially contributing to dry eye disease.
Researchers found that sustained blue-light exposure can weaken corneal antioxidant defenses and trigger an iron-dependent
form of ce...
Oxidative Damage May Persist Long After Infection
Scientists studying long COVID have found striking evidence that the body can remain under prolonged oxidative stress months, and sometimes years, after the original coronavirus infection.
Long COVID patients showed substantially greater oxidative damage together with weakened antioxidant
defenses, even many months after their initial infect...
A natural pigment found in dark berries may help make glioblastoma cells more vulnerable to chemotherapy by weakening one of the cancer’s drug-defense systems, according to new laboratory research.
A berry-derived antioxidant reduced a major drug-resistance mechanism and strengthened chemotherapy
effects in laboratory glioblastoma cells.
Why Glioblastoma Is So Difficult to Treat
Gl...
Long COVID may affect more than the lungs, heart, brain and nervous system. A newly published case report suggests that problems involving the salivary glands and their drainage ducts can appear months after repeated SARS-CoV-2 infections, causing severe dry mouth, facial swelling and considerable pain.
An unusual case suggests long COVID may be linked to severe salivary duct enlargement, dry...
Endometriosis is notoriously difficult to treat because it is not driven by one biological problem. A new scientific review suggests that several naturally occurring bioactive compounds may be able to influence multiple processes that help endometriosis lesions survive, grow and spread.
Natural bioactive compounds may simultaneously influence several biological pathways that help endometriosi...
A natural plant compound called berberine and newer substances derived from it could offer researchers another way to fight Helicobacter pylori, the stomach bacterium linked to chronic gastritis, peptic ulcers and gastric cancer.
Berberine and advanced derivatives could weaken H. pylori by attacking bacterial survival, biofilms, drug resistance
and stomach inflammation simultaneously
...
Scientists are questioning the long-held idea that simply taking antioxidant supplements can reliably protect against cardiovascular disease. However, that does not mean researchers are rejecting all antioxidant-related compounds. Instead, emerging evidence highlighted in a new scientific editorial shows promising cardiovascular effects from compounds including resveratrol and urolithin A, while e...
Severe cases and deaths climb sharply
Taiwan is facing a renewed COVID-19 surge, with health authorities reporting 72 new domestic severe cases and 14 deaths between August 4 and 10, marking a concerning acceleration in serious disease. The Taiwan Centers for Disease Control said severe cases increased from 62 during the preceding seven days, while deaths jumped from three to 14.
Taiwan’s ...
A fascinating medical study has identified a traditional Thai medicinal plant with particularly strong laboratory activity against six cancer cell lines representing malignancies of the upper respiratory tract. The findings are drawing attention to Caesalpinia sappan, or sappanwood, an ingredient found in Kampramong’s traditional anticancer remedy.
Thai researchers found that sappanwood...
Long COVID remains a major medical challenge, particularly for patients affected by post-exertional malaise (PEM) and persistent cognitive problems commonly described as “brain fog.” These symptoms can interfere with employment, household activities, exercise and even relatively minor physical or mental tasks.
A new scientific review proposes investigating eight nutraceuticals tar...
A potential new eye-drop treatment for dry eye syndrome has shown encouraging results in laboratory and animal experiments, with researchers reporting improvements in inflammation-related eye damage and protection of important tear-film-supporting cells.
Experimental fenofibric acid eye drops reduced corneal swelling and improved recovery of protective goblet cells in a
rat model of dry eye
...
A major genetic investigation of the 2026 Bundibugyo Ebola outbreak in the Democratic Republic of the Congo (DRC) and Uganda has found that the virus appears to have emerged from a new animal-to-human spillover, rather than returning from viruses responsible for earlier outbreaks.
Genetic sequencing reveals that the 2026 Bundibugyo Ebola outbreak likely began with a new animal-to-human spillo...
A commonly used mucus-clearing drug could have a potentially broader role against respiratory viral infections. Researchers are proposing that bromhexine hydrochloride may help reduce the severity of COVID-19 and influenza when used prophylactically, while potentially allowing enough viral exposure for the immune system to develop longer-lasting protection.
Bromhexine is being investigated as a ...
Two commonly used medicines, paracetamol and metformin, may unexpectedly help surviving breast cancer cells become harder for Natural Killer (NK) immune cells to destroy, according to a new laboratory study. The findings reveal a striking treatment paradox: both drugs slowed cancer-cell growth but also promoted changes associated with immune escape.
Paracetamol and metformin altered breast ca...
A new study has uncovered distinctive changes in blood metabolism among people suffering from neuropsychiatric Long COVID, offering fresh clues as to why patients can experience persistent fatigue, low mood and cognitive difficulties months after their initial SARS-CoV-2 infection.
Researchers have identified distinctive metabolic changes linked to fatigue, depressive symptoms and brain struc...
Artificial intelligence has crossed another potentially consequential frontier in biology, with scientists demonstrating that generative AI can design complete viral genomes that, once synthesized in a laboratory, produce functional viruses capable of infecting and destroying bacteria.
Scientists have demonstrated that generative AI can design complete functional bacteriophage genomes, openin...
A detailed investigation of intestinal tissue from people with Long COVID has uncovered signs of lingering SARS-CoV-2 alongside major disturbances in the gut’s immune defenses, potentially offering important clues about why symptoms can continue for years after the original infection.
Scientists find lingering SARS-CoV-2 signals and widespread immune disruption in colorectal tissue from...
Scientists have uncovered an unexpected way SARS-CoV-2 may activate one of the body’s important antiviral defenses. Rather than simply recognizing genetic material belonging to the virus, the immune sensor MDA5 appears able to detect disruptions that infection causes to the cell’s own RNA-processing system.
SARS-CoV-2 disrupts normal cellular RNA processing, producing abnormal hos...
A major systematic review involving data from tens of millions of people has found that COVID-19 infection is consistently associated with an increased risk of developing new autoimmune and autoinflammatory diseases. The findings suggest the effect can involve the joints, skin, blood vessels, thyroid, digestive system, blood and nervous system, although the absolute risk for any individual remains...
Thai researchers have discovered that oils extracted from red and purple rice bran may contain an impressive combination of natural compounds capable of protecting bone-forming cells from oxidative stress and inflammation while also encouraging biological processes involved in building and maintaining bone.
Thai researchers found that red and purple rice bran oils could reduce cellular stress...
A randomized clinical trial from Taiwan has found that beta-glucan supplementation may help patients with advanced cancers maintain more stable immune function while undergoing chemotherapy. The findings are particularly interesting because chemotherapy can damage rapidly dividing cancer cells but can also suppress bone marrow and weaken important immune defenses.
Beta-glucan supplementation ...
The neurological consequences of COVID-19 continue to attract intense scientific attention as researchers investigate why some patients develop persistent brain fog, fatigue, anxiety, sleep disturbances, autonomic problems, and other neurological or neuropsychiatric symptoms. One emerging area of interest involves oxytocin, a neuropeptide whose functions extend far beyond social bonding.
Emer...
A naturally occurring compound found in extra-virgin olive oil has produced striking results against an aggressive form of colorectal cancer in laboratory mice, sharply reducing primary tumors and preventing much of the cancer from spreading to other organs.
Olive oil compound oleocanthal dramatically reduced KRAS-mutant colorectal tumors and metastatic spread in experimental
mice
The phy...
A major multinational study has raised new concerns about the possible long-term effects of COVID-19, finding that people with existing thyroid disorders who had COVID-19 were more likely to later be diagnosed with thyroid cancer than comparable patients without a recorded SARS-CoV-2 infection.
A large multinational study found a higher long-term rate of thyroid cancer diagnosis following COV...
Statins are among the most widely prescribed medicines worldwide, helping millions of people lower cholesterol and reduce their risk of heart attacks and strokes. However, a new large-scale drug safety analysis has raised fresh concerns about possible links between certain statins and reports of amnesia, or significant memory loss.
A major analysis of FDA adverse-event reports found significa...
Scientists have uncovered a striking way in which a SARS-CoV-2 protein can interfere with the tiny energy-producing structures inside human cells. The study focused on ORF7a, an accessory protein made by the virus, and found that it can dramatically reprogram cellular metabolism while weakening mitochondrial energy production.
SARS-CoV-2 protein ORF7a can rewire cellular metabolism and disrup...
Changing to a vegan diet could begin altering how certain genes behave within just four weeks, according to intriguing new research showing surprisingly rapid molecular changes linked to inflammation, metabolism, cancer-related pathways and biological aging.
A one-month vegan diet triggered measurable changes in DNA methylation linked to inflammation, metabolism,
cell growth and biological a...
A new murine study has found that SARS-CoV-2 infection can intensify abnormalities involving dopamine, brain immune cells and nerve-cell degeneration in a mouse model of early Parkinson’s disease. The effects were particularly pronounced in male mice, while females showed considerably greater resistance to neurological damage.
Murine research shows SARS-CoV-2 can amplify dopamine disrup...
Ulcerative colitis is a chronic inflammatory bowel disease that damages the lining of the large intestine, causing inflammation, ulcers and recurring flare-ups. Scientists are now investigating whether two antioxidant compounds, N-acetylcysteine (NAC) and Tiron, could help protect intestinal tissue from some of this damage.
NAC and Tiron reduced colon inflammation, oxidative damage and tissue...
Doctors are drawing attention to a rare but potentially serious blood complication that can appear weeks or even months after SARS-CoV-2 infection. A newly published case and review suggest that COVID-19 may trigger pure red cell aplasia (PRCA), a disorder in which the bone marrow suddenly becomes unable to produce enough red blood cells.
Doctors report that SARS-CoV-2 may rarely trigger severe ...
Glaucoma is widely associated with increased pressure inside the eye, but scientists are increasingly finding that the disease involves far more than eye pressure alone. A detailed scientific review has highlighted how two important retinal cell types—astrocytes and Müller glia cells—can undergo major changes that may accelerate inflammation, nerve damage and glaucoma progression....
Energy drinks have become a routine choice for teenagers and young adults seeking extra energy, sharper concentration or better athletic performance. But a new scientific review warns that these highly caffeinated beverages may temporarily alter the heart’s electrical activity and, in some circumstances, could help trigger dangerous abnormal heart rhythms.
New research warns that energy...
A new Thai laboratory and animal study has found that an extract made from Mucuna pruriens var. pruriens, commonly known as velvet bean, can influence several biological processes involved in achieving an erection. Importantly, researchers found that the effects appeared to involve blood-vessel signaling rather than increased testosterone.
Thai researchers found velvet bean seed extract influ...
Omega-3 fatty acids found in fish, seafood, algae, nuts and seeds may influence far more aspects of brain aging than previously appreciated. A major scientific review has brought together evidence showing that these dietary fats can affect inflammation, blood vessels, brain-cell communication, energy production and other biological processes involved in age-related cognitive decline.
Food-der...
Researchers investigating natural approaches to excessive inflammation during respiratory viral infections have found that extracts of Cistus incanus and Rosmarinus officinalis, commonly known as rosemary, strongly reduced inflammatory responses in human lung cells subjected to an Influenza A-like laboratory challenge.
Cistus and rosemary extracts sharply reduced inflammatory signals in human...
Scientists have uncovered how a key SARS-CoV-2 enzyme can simultaneously weaken the body's early antiviral defenses and reorganize the metabolism of infected cells, creating conditions that help the coronavirus multiply.
The study focused on the viral papain-like protease, or PLpro, an enzyme contained within the SARS-CoV-2 Nsp3 protein. Researchers discovered that PLpro removes prote...
Neuropathic pain can be extremely difficult to treat because the problem involves much more than damaged or overactive nerves. New laboratory research suggests that specially modifying platelet-rich plasma, or PRP, could potentially influence the inflammatory processes that help keep this type of chronic pain alive.
Modified platelet-rich plasma showed powerful effects on inflammation and ner...
Scientists investigating why COVID-19 antibodies remain detectable longer in some people than others have found that a naturally occurring hormone may provide an important part of the answer. New research suggests that levels of 17β-estradiol, a form of estrogen found in both women and men, are strongly associated with how long antibodies against SARS-CoV-2 persist after infection. Researcher...
Thailand Medical Researchers have reported promising findings showing that an automated urine analysis measurement could help doctors determine whether blood found in urine originates from diseases affecting the kidney’s filtering structures. The approach could be particularly useful in hospitals where experienced specialists in microscopic urine examination are not readily available.
T...
COVID-19 may have lasting effects on the body’s ability to control blood sugar, with growing evidence suggesting that SARS-CoV-2 can interfere with pancreatic beta cells, the specialized cells responsible for producing and releasing insulin. Researchers warn that these disturbances could help explain why some people develop abnormal blood sugar or newly diagnosed diabetes during or after COV...
People suffering from long COVID-related chronic fatigue may experience depression differently from those with typical depression, according to a new study by researchers from the University Hospital of Cagliari, the University of Cagliari, the Federico II University of Naples, the University of Kore, and the Federal University of Rio de Janeiro. Rather than feeling overwhelmingly sad, many patien...
Researchers Discover Natural Pigment That Protects Brain Cells in Lab Tests
Scientists in Taiwan have identified a naturally occurring compound from algae that may help protect brain cells from one of the damaging processes linked to Alzheimer’s disease. The research suggests that phycocyanobilin (PCB), a pigment found in cyanobacteria and red algae, can reduce harmful cellular aging and inf...
Natural compounds from medicinal mushroom may calm harmful brain inflammation
Scientists have discovered that ganoderic acids, a group of natural compounds extracted from the medicinal mushroom Ganoderma lucidum (Reishi), could help protect the brain after an ischemic stroke by blocking excessive inflammation. The international research team included scientists from Peking University, the China A...
Italian Study Reveals How Immune Overreaction and Iron Disruption May Drive Serious Illness and Long COVID
Researchers from IRCCS MultiMedica, Italy, and the Università degli Studi dell'Insubria, Varese, Italy, have uncovered compelling evidence that excessive inflammation and abnormal iron metabolism are closely linked to the severity of COVID-19. Their findings also suggest that thes...
Long COVID Recovery Remains Slow for Many
A major four-year study involving 3,590 people with long COVID has revealed that only about one in three patients achieved a satisfactory level of recovery, highlighting the lasting health burden caused by the condition. Researchers say fatigue, muscle pain and problems affecting the body's automatic functions were among the strongest warning signs th...
