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BREAKING NEWS
Source: University of Virginia  Feb 15, 2019  5 years, 2 months, 4 days, 13 hours, 45 minutes ago

Antidepressant drug, Fluvoxamine stops deadly Sepsis

Antidepressant drug, Fluvoxamine stops deadly Sepsis
Source: University of Virginia  Feb 15, 2019  5 years, 2 months, 4 days, 13 hours, 45 minutes ago

An antidepressant drug used to treat obsessive-compulsive disorder could save people from deadly sepsis, new research from the University of Virginia School of Medicine suggests.

ntidepressant drug

Sepsis is a significant cause of death around the world. The federal Centers for Disease Control and Infection calls it "the body's extreme response to an infection." Essentially, the body's immune response spirals out of control, and the normally beneficial inflammation becomes harmful. The result can be tissue damage, organ failure or even death.

"Sepsis is very dangerous. In the U.S., 1.7 million [people] get it every year, and 270,000 people die," said researcher Alban Gaultier of UVA's Department of Neuroscience and its Center for Brain Immunology and Glia, or BIG in an interview with Thailand Medical News. "Once you get diagnosed, you have a high chance of mortality. And there is no good treatment. Basically, we will try to keep you alive and monitor you as much as we can. So clearly there is a critical need for treatment."

Gaultier and his team have identified a drug that could offer that treatment – and previous safety testing of the drug could fast-track it into use in hospitals around the country.

A Simple Solution for Sepsis?

The UVA researchers were looking at a little-studied biological process inside our cells when they determined it has an important role in regulating inflammation. They began studying it partly because there are already drugs that can affect some of the biological players in the process.

"Inflammation, most of the time, is good. It's when it gets out of control that we need to modulate it,"